Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine
(OC) pesticide, chlordecone (CD), stimulated biliary excretion of exogenous CH up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding
cassette transporter G8 (ABCG8) of the bile canaliculus or scavenger receptor class B
type I (SR-BI)...
OWET commissioned this gap analysis to assess the infrastructure needs of ocean renewable energy and compare those needs against the existing and planned infrastructure capabilities in Oregon. The Wave Energy Infrastructure Assessment in Oregon report summarizes the results of the assessment performed by Advanced Research
Corporation and is intended to...
Quadrotors are unique among Micro Aerial Vehicles in providing excellent maneuverability (as opposed to winged flight),while maintaing a simple mechanical construction (as opposed to helicopters). This mechanical simplicity comes at a cost of increased controller complexity. Quadrotors are inherently unstable, in the sense that they are essentially unflyable by a...
Epichloë typhina (Ascomycetes: Clavicipitaceae) is an endophytic fungus that
infects perennial Pooid grasses and is the causal agent of choke disease. It is endemic
to Europe and was inadvertently introduced into orchardgrass seed production fields in
western Oregon. Choke disease, which was first recorded in Oregon in 1996, currently
infects...
End users' programs are fraught with errors, costing companies millions of dollars. One reason may be that researchers and tool designers have not yet focused on end-user debugging strategies. To investigate this possibility, this dissertation presents eight empirical studies and a new strategy-based end-user debugging tool for Excel, called StratCel....
Quantitative procedures were developed to determine the effect of variability in the model parameters required for the estimation of microbial shelflife and thermal processing time. Monte Carlo simulations combined with these predictive models were implemented in Microsoft Excel™. In the first study,
predictive models were used for shelf-life predictions based...
The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
The bi-directional relationships within the personal and contextual environments of adolescents are critical to the development of adolescents and their transition into adulthood. Opportunities for youth to participate in and provide leadership in meaningful programs, gain life skills, and interact with adults in sustained relationships are key features leading to...
Reinforcement learning in real-world domains suffers from three curses of dimensionality: explosions in state and action spaces, and high
stochasticity or "outcome space" explosion. Multiagent domains are particularly susceptible to these problems. This thesis describes ways to mitigate these curses in several different multiagent domains, including real-time delivery of products...
This thesis presents a progression of novel planning algorithms that culminates in a new family of diverse Monte-Carlo methods for probabilistic planning domains. We provide a proof for performance guarantees and analyze how these algorithms can resolve some of the shortcomings of traditional probabilistic planning methods. The direct policy search...