Cyprinid herpesvirus 3 (CyHV-3), commonly known as koi herpesvirus (KHV), is a member of the Alloherpesviridae, and is a recently discovered emerging herpesvirus that is highly pathogenic for koi and common carp. Our previous study demonstrated that CyHV-3 becomes latent in peripheral white blood cells (WBC). In this study, CyHV-3...
Gibbs sampling method is an important tool used in parameter estimation for many probabilistic models. Specifically, for many scenarios, it is difficult to generate high-dimensional data samples from its joint distribution. The Gibbs sampling provides a way to draw high-dimensional data via the conditional distributions which are typically easier to...
Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans and an
expression level-dependent phenotype in transgenic rodents. We show that oral treatment with the therapeutic agent diacetyl-bis(4-methylthiosemicarbazonato)copper[superscript II] [Cu[superscript II](atsm)] increased the concentration of mutant SOD1 (SOD1G37R) in ALS model mice, but paradoxically improved locomotor...
Flame retardants are in many home products including couches, chairs, and electronics. The most commonly used flame retardants contained polybrominated diphenyl ethers (PBDEs) until 2004, when the majority of these chemicals were phased out. PBDEs were found to be persistent, bioaccumulative, and toxic to both humans and the environment. Organophosphate...
How does transboundary water cooperation begin at the initial stages? Countries in many transboundary basins either do not cooperate at all or have ceased cooperation altogether. Yet cooperation does often prevail, resulting in 688 water-related treaties signed between 1820 and 2007. The question we address here is, by which practices...
The Pastos Grandes Caldera Complex (PGCC) in southwest Bolivia has produced two large-volume (≥800 km³ DRE) dacite ignimbrites from a nested caldera source over a period of 5.5 Myr. In addition to the large-volume ignimbrites, a small-volume ignimbrite shield and post-climactic lavas define this composite system. Based on detailed field...
The purpose of this article is to explore student reasoning with regard to problems in logic, particularly those related to the Principle of Mathematical Induction (PMI). The five case studies presented build off of work done by other researchers, most notably Dubinsky and Harel, who both looked at how students'...
The over-arching theme of this work is that soil data affect the performance and realism of vegetation models with particular focus on their ability to predict or explain disturbances such as fire or disease. We tested the sensitivity of the Excel version of the 3-PG model to soil properties and...
Populations of organisms are influenced by both top-down (predator driven) and bottom-up (environment or resource driven) effects. Seabird research has largely focused on bottom-up factors influencing reproduction, with little emphasis on top-down. Our goal was to better understand top-down impacts on colonial nesting seabirds over a range of spatio-temporal scales....
After decades of expert-based modernization efforts that have had profound negative impacts on human and environmental health, Ecuador is currently pursuing a rights-based, participatory development paradigm known as sumak kawsay or "the good life". Despite its promises of inclusion and interculturality, this approach continues to rely on highly trained specialists,...