Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
American Indians and Alaska Natives (AIAN) have more negative sexual and reproductive health outcomes than non-Hispanic whites. Little is known, however, about the factors that lead to sexual and reproductive health disparities for AIANs, including the role of sexual and reproductive health services (SRHS).
Logistic regression analyses were performed on...
Testosterone plays an essential role in sexual differentiation of the male sheep brain. The ovine sexually dimorphic nucleus (oSDN), is 2 to 3 times larger in males than in females, and this sex difference is under the control of testosterone. The effect of testosterone on oSDN volume may result from...
Bioretention is a common form of green stormwater infrastructure that is used to attenuate peak flows from urban stormwater. Previous research shows that the bioretention peak response is not consistent across time or space and that the variables that affect peak hydrology are numerous. One variable that has not been...
Individuals who have been traumatized have the opportunity to experience posttraumatic growth, conceptualized as positive changes that result from navigating highly challenging life circumstances (Tedeschi & Calhoun, 2004). The current model of posttraumatic growth (Calhoun, Cann, & Tedeschi, 2010) is based solely on cognitive-emotional processing yet by examining the role...
The Open Modeling Environment (OME) is a tool developed to address some known shortcomings in ecological System Dynamics (SD) modeling research. OME provides a common set of methods for interacting directly with spatial information, reducing the need for modelers to create their own methods for doing so. The environment is...
Systems that contain multi-phase flow in porous media are of interest in diverse fields including environmental engineering, hydrogeology, and petroleum engineering etc. One of the main descriptors of multi-phase flow in porous media is the relationship between capillary pressure and fluid saturation. Capillary pressure is inherently a pore-scale variable and...
An ability to meet the changing demands associated with development
promotes purpose in life, a defining feature of psychological well-being. Midlife
adults consistently report higher purpose in life compared to older adults. However,
less is known about the dynamics of purpose in life in the transition from middle to
older...
The Syrian civil war generated waves of refugees who flow into neighboring countries. These refugees have been creating excess supply of labor in host countries. This study involves a series of interviews in which respondents shared their perceptions of their involvement in the labor market in Iraq. These interviews provide...
The anthropogenic introduction of nutrients to water bodies has been shown to alter the structure and function of natural aquatic ecosystems, yet national EPA lake and reservoir nutrient criteria remain too broad for effective regional water quality management. This study uses a reference site approach to propose numeric nutrient criteria...