OBJECTIVE: We studied the extent to which parent marijuana use in adolescence is associated with marijuana use onset in offspring through contextual family and peer risks.
METHOD: Fathers
assessed (n = 93) since childhood, their 146 offspring (n = 83 girls), and offspring’s mothers (n = 85) participated in a...
The idea that climatically modulated erosion may impact orogenic processes has challenged geoscientists for decades. Although modeling studies and physical calculations have provided a solid theoretical basis supporting this interaction, to date, field-based work has produced inconclusive results. The central-western Alborz Mountains in the northern sectors of the Arabia-Eurasia collision...
The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs. In the absence...
FVB/N mice wild-type, heterozygous or null for Cyp 1b1 were used in a two-stage skin tumor study comparing PAH, benzo[a]pyrene (BaP), dibenzo[def,p]chrysene (DBC), and coal tar extract (CTE, SRM 1597a). Following 20 weeks of promotion with TPA the Cyp 1b1 null mice, initiated with DBC, exhibited reductions in incidence, multiplicity,...
The Amazon rainforest is a critical hotspot for bio-diversity, and plays an essential role in global carbon, water and energy fluxes and the earth's climate. Our ability to project the role of vegetation carbon feedbacks on future climate critically depends upon our understanding of this tropical ecosystem, its tolerance to...
To understand causes and consequences of landscape change, it is often not enough to simply detect change. Rather, the agent causing the change must also be determined. Here, we describe and test a method of change agent attribution built on four tenets: agents operate on patches rather than pixels; temporal...
A new metric for ranking the suitability of fuels in LTC engines was recently introduced, based on the fraction of potential fuel savings achieved in the FTP-75 light-duty vehicle driving cycle. In the current study, this LTC fuel performance index was calculated computationally and analyzed for a number of fuel...