Index Catalog // ScholarsArchive@OSU

Whole system perspective : Steelhead, Onchorhynchus mykiss, glutathione s-transferase as a biomarker of chlorpyrifos exposure

Creator:: Pecore, Rachael G.
Abstract:: Organophosphate insecticides may produce sublethal, adverse effects on salmonid growth, reproduction, maturation, swimming, and feeding. Chlorpyrifos, an organophosphate insecticide, was detected by the Oregon Department of Environmental Quality in the Hood River and tributaries during March 1999 at levels exceeding state water quality standards in the range of 0.011-0.482 μg/L....
Resource Type:: Undergraduate Thesis

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Creator:: Luo, Yun L.
Abstract:: Polycyclic Aromatic Hydrocarbons (PAHs) have been studied for their carcinogenic toxicity. PAHs are formed by incomplete carbon combustion. Benzo[a]pyrene (BaP) is an IARC classified Class 1 Human carcinogenic PAH. New studies are conducted to gain a better understanding of PAHs and how to reduce exposure. Glutathione S-transferase M 1 (GSTM1...
Resource Type:: Honors College Thesis
Full Text:: Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro

An Evaluation of Staffing Needs at the Health Clinic in Maunatlala, Botswana

Creator:: Bedge, Sonya S.
Abstract:: As part of the Botswana Global Learning Internship Program, a qualitative study was conducted regarding the current staffing conditions at the local village health clinic in Maunatlala, Botswana. This was a month-long project conducted over the summer of 2018. Students from Oregon State University lived in the village of Maunatlala...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ William V. Massey, Committee Member, representing School of Biological and Population Health

Determination of flavin-containing monooxygenase mRNA levels in mouse lung and liver

Creator:: Lo, Pachida C.
Abstract:: We are developing a flavin-containing (Fmo) knock-out mouse for Fmo2 that will be utilized to elucidate the role of active human FMO isoform 2 (FMO2.1) in xenobiotic metabolism and toxicity. Since FMO2 is primarily expressed in lung this will provide information on how 27% of African-Americans and 5% of Hispanics...
Resource Type:: Honors College Thesis

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: Environmental and Molecular Toxicology/Linus Pauling Institute William M. Baird, Committee Member

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

Creator:: Raymundo, Wilfrido E.
Abstract:: Testing the many potential chemoprevention agents from dietary sources in animal or human models is expensive and takes a long time. In vitro models can be useful for screening the right compounds to use in larger studies. We tested the MatTek™ EpiIntestinal™ small intestine epithelial 3D cell culture model for...
Resource Type:: Undergraduate Thesis
Full Text:: related factor (Nrf2), signaling (Clark et al., 2008). Nrf2 regulated enzymes such as glutathione-s

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Creator:: Mans, Michael-Andres D.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants ubiquitous in the environment and result from the incomplete combustion of fossil fuels. Many PAHs have been identified as procarcinogenic, and are metabolized to form DNA adducts; however, other mechanisms also may contribute to toxicity and help explain differences in toxicity...
Resource Type:: Undergraduate Thesis
Full Text:: signaling pathway Cell adhesion_Cell junctions Cell cycle_G1-S Growth factor regulation

A Comparative Analysis of Mercury and Lead in Sindoor from the U.S. and Bangladesh

Creator:: Breen, Anna K.
Abstract:: Heavy metals have historically been popular for use in cosmetics manufacturing due to the colorful pigmentation of heavy metal compounds. In the case of sindoor, a cosmetic used by married Hindu women for religious purposes, mercury sulfide, lead tetroxide, and lead chromate are compounds suspected to still be involved in...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ William Stubblefield, Committee Member, representing Environmental and Molecular Toxicology

Unprecedented Retreat of Columbia Glacier Relative to the Last Millennium

Creator:: Kilmer, Zoe
Abstract:: Columbia Glacier, Alaska’s most rapidly retreating body of ice, provides a compelling insight into the fragile state of tidewater glaciers worldwide. Catastrophic retreat of the glacier’s terminal ice margin began in 1978 when contact was lost with its stabilizing terminal moraine shoal. Since this time, Columbia Glacier has lost ~20...
Resource Type:: Undergraduate Thesis
Full Text:: originates at 3500m in the Chugach Mountain range of Alaska’s south central Prince William

Soil Fire Ecology: Assessing Wildfire Severity Impacts on Pacific Northwest Forest Soil Carbon

Creator:: Fleetwood, Shea
Abstract:: Pacific Northwest temperate rainforests are anticipated to experience increasingly frequent and severe wildfires in the foreseeable future due to climate change, increased fuel loads, and deforestation. Soil, underlying these forests, is the largest terrestrial carbon (“C”) reservoir. Fire disturbance influences soil C persistence, the timeframe and magnitude of which remain...
Resource Type:: Undergraduate Thesis
Full Text:: . Biological Conservation, 169, 362–371. https://doi.org/10.1016/j.biocon.2013.12.003 Bruun, S., Jensen, E. S

ScholarsArchive@OSU

Whole system perspective : Steelhead, Onchorhynchus mykiss, glutathione s-transferase as a biomarker of chlorpyrifos exposure

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

An Evaluation of Staffing Needs at the Health Clinic in Maunatlala, Botswana

Determination of flavin-containing monooxygenase mRNA levels in mouse lung and liver

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

A Comparative Analysis of Mercury and Lead in Sindoor from the U.S. and Bangladesh

Unprecedented Retreat of Columbia Glacier Relative to the Last Millennium

Soil Fire Ecology: Assessing Wildfire Severity Impacts on Pacific Northwest Forest Soil Carbon

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