Index Catalog // ScholarsArchive@OSU

Structural Insights into Novel Sugar Phosphate Cyclases and Flavoenzymes

Creator:: Kean, Kelsey M.
Abstract:: The function of a protein is defined by its three-dimensional structure, and in understanding the three-dimensional structure of a protein, we gain an understanding of its function and mechanism. Protein structures, especially at high resolution, can provide detailed insights into many elements of enzyme function and catalysis – identifying residues...
Resource Type:: Dissertation
Full Text:: work is crystallography so much of my work was made possible by regular, free access to the Advanced

Modeling protein structure at atomic resolution

Creator:: Berkholz, Donald S.
Abstract:: This thesis includes three studies involving different aspects of modeling protein structure. The first study illustrates the levels of insight available from atomic-resolution protein structures. The second study derives general trends of protein geometry from atomic-resolution structures and shows their implications for modeling. The third study creates a model of...
Resource Type:: Dissertation
Full Text:: radiation damage in macromolecular crystallography. Acta Crystallogr. D Biol. Crystallogr. 62, 32-47

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Creator:: Perkins, Arden
Abstract:: Peroxiredoxin (Prx) enzymes catalyze the reduction of hydrogen peroxide, peroxynitrous acid, and organic peroxides, and are extremely efficient peroxidases, with k[subscript cat]/K[subscript M] on the order of 10⁷ - 10⁸ M⁻¹ s⁻¹. Besides their role in oxidative stress defense, evidence has accumulated that some eukaryotes, including humans, use Prxs as...
Resource Type:: Dissertation
Full Text:: things he has done to help me and teach me about the field of protein crystallography, protein

Characterization of the SARS-CoV-2 Nucleocapsid Protein and the Binding to Different Sections of the SARS-CoV-2 Genome

Creator:: Pinckney, Seth H.
Abstract:: The nucleocapsid protein (N protein) of the severe acute respiratory syndrome coronavirus 2 is known to play an essential part of the virus’ functions. The N protein can protect and package the large 29,903 nucleotide genomic RNA whilst also interacting with structural membrane protein M and the spike protein S....
Resource Type:: Honors College Thesis
Full Text:: ). Both the CTD and NTD have had their structures solved through X-ray crystallography and/or NMR; the

The asymmetric binding of Actinomycin D to DNA hexamers

Creator:: Ivancic, Monika
Abstract:: The solution structure determination of DNA molecules has been an important part of structural biology. NMR solution structures are a complement to structures solved via X-ray crystallography; the two methods are the only ways of obtaining three dimensional coordinates of macromolecules. Because of the nature of the molecule, the solution...
Resource Type:: Dissertation
Full Text:: structures solved via X-ray crystallography; the two methods are the only ways of obtaining three

Steps toward structure-assisted drug design

Creator:: Watts, K. Shawn
Abstract:: The three dimensional structure of both a ligand and its cognate receptor are required for the success of structure-assisted drug design. This thesis reports the crystal structure of hectochlorin, a small, bioactive molecule, and the steps toward determining the crystal structure of an RNA molecule that is an attractive target...
Resource Type:: Masters Thesis
Full Text:: absolute configuration of hectochiorin, as determined by x-ray crystallography, is reported as 6S, 7S

Base specific binding of copper (II) to Z-DNA : 1.3 A single crystal structure of d(m⁵CGUAm⁵CG) soaked with CuCl₂

Creator:: Geierstanger, Bernhard H.
Resource Type:: Masters Thesis
Full Text:: section along the z-axis of the 2Fobs-Fcal 6 6 electron density map of the copper(II)-soaked d(CG)3

Circular dichroism spectroscopy and the conformational analysis of globular proteins in the native and denatured state

Creator:: Compton, Larry A.
Abstract:: A simple matrix method for the analysis of protein circular dichroism (CD) spectra is presented and used to compute the secondary structure of globular proteins in their native and denatured states. The method uses singular value decomposition and generalized inverse algorithms, and a basis set of CD spectra for proteins...
Resource Type:: Dissertation
Full Text:: whose secondary structures are known from x-ray crystallography. Inverse CD functions for five major

Specific enzymic interactions relating to the mechanism of action on certain 2-chloroethyl nitrosoureas

Creator:: Babson, John Robert
Abstract:: Certain 2- chioroethyl nitrosoureas have been demonstrated to be highly specific inactivators of chymotrypsin in vitro and glutathione reductase, both in vivo and in isolated rat hepatocytes. The inactivation of glutathione reductase in isolated hepatocytes resulted in an increased sensitivity toward an adriamycin induced oxidative challenge. Prolonged incubation of 1-(2-chloroethyl)-3-([1-¹⁴...
Resource Type:: Dissertation
Full Text:: section on nitrosoureas, these methods are far from ideal. Chymotrypsin--A Model System Chymotrypsin

Nucleosome instabilities in physiological salt

Creator:: Yager, Thomas D.
Abstract:: Best scan available for figures. Some figures are high gloss photos, others are black and white photocopies.
Resource Type:: Dissertation
Full Text:: Instabilities in Physiological Salt by Thomas D. Yager A THESIS submitted to Oregon State University in

ScholarsArchive@OSU

Structural Insights into Novel Sugar Phosphate Cyclases and Flavoenzymes

Modeling protein structure at atomic resolution

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Characterization of the SARS-CoV-2 Nucleocapsid Protein and the Binding to Different Sections of the SARS-CoV-2 Genome

The asymmetric binding of Actinomycin D to DNA hexamers

Steps toward structure-assisted drug design

Base specific binding of copper (II) to Z-DNA : 1.3 A single crystal structure of d(m⁵CGUAm⁵CG) soaked with CuCl₂

Circular dichroism spectroscopy and the conformational analysis of globular proteins in the native and denatured state

Specific enzymic interactions relating to the mechanism of action on certain 2-chloroethyl nitrosoureas

Nucleosome instabilities in physiological salt

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