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Filtering by: Creator Jeffreys, Bradford J. Remove constraint Creator: Jeffreys, Bradford J. Degree Field Biochemistry and Biophysics Remove constraint Degree Field: Biochemistry and Biophysics

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  • Characterization of the infection cycle of the Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus in Lymantria dispar cells

    Creator:
    Bradford, Mary Beth
    Abstract:
    The Baculoviridae is a family of DNA viruses which are obligate pathogens for a variety of insects. Baculovirus strains came to the attention of researchers because they provided a nonchemical alternative for the biological control of insect pests of agriculture and forestry (Ignoffo, 1968); however, recently they have been studied...
    Resource Type:
    Masters Thesis
    Full Text:
    Mary B. Bradford for the degree of Master of Science in Biochemistry/Biophysics presented on June 8

  • Cytoskeletal regulation in cell motility and invasion

    Creator:
    Jang, Hyo Sang
    Abstract:
    Cell motility and invasion are important for development, immunity, wound healing, and tumor cell metastasis. Cells on two dimensional substrates migrate in three steps: protrusion of the front end, translocation of the cell body, and retraction of the rear end. For cells to migrate efficiently, these steps need to be...
    Resource Type:
    Dissertation
    Full Text:
    and Invasion Abstract approved: Jeffrey A. Greenwood Cell motility and invasion are important for

  • A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

    Creator:
    Monette, Jeffrey S.
    Abstract:
    Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Jeffrey

  • Calpain 2 proteolysis regulates glioblastoma cell invasion

    Creator:
    Lal, Sangeet Kumar
    Abstract:
    Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...
    Resource Type:
    Dissertation
    Full Text:
    Glioblastoma Cell Invasion Abstract approved: Jeffrey A. Greenwood Glioblastoma

  • Pyruvate kinase isozymes in beef and chicken

    Creator:
    Strandholm, John Jeffrey, 1945-
    Resource Type:
    Dissertation
    Full Text:
    ABSTRACT OF THE THESIS OF John Jeffrey Strandholm for the degree of Doctor of Philosophy in Biochemistry

  • The effect of cytosine methylation on DNA structure

    Creator:
    Vargason, Jeffrey M.
    Abstract:
    DNA methylation is common in prokaryotes and eukaryotes and has been implicated in various biological roles including gene silencing, X-chromosome inactivation, and genomic imprinting. 5-methylcytosine the "fifth base" of the genetic code comprises 1-3% of the human genome and is primarily found on cytosines within the context of the CpG...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Jeffrey M. Vargason for the

  • Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

    Creator:
    Rhoads, Timothy W.
    Abstract:
    Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...
    Resource Type:
    Dissertation
    Full Text:
    Bradford provided the laser capture microdissection data for Chapter 3. Brian Arbogast and Jeff Morré

  • Interaction of linker proteins, H1 and HMG1, with nucleosome reconstituted on positioning sequences

    Creator:
    An, Woojin
    Abstract:
    The aim of this research was to gain more understanding on how a linker histone (LH), H1⁰, and high mobility group protein, HMG1, interact with nucleosome. To determine the location of linker proteins, three specific positioning sequences were used to reconstitute core nucleosomes and the binding of H1 and HMG1...
    Resource Type:
    Dissertation
    Full Text:
    members, Dr. Neil Forsberg, Dr. Victor Hsu, Dr. Gary Merrill and Dr. Jeffrey Stone (Graduate Council

  • Lysophospholipase of germinating barley seeds

    Creator:
    Fujikura, Yuzo
    Abstract:
    The amylose component of cereal starch contains lysophospholipid, predominantly lysophosphatidylcholine (LPC) as inclusion complexes. As starch undergoes degradation by amylases during barley germination, lysophospholipase (LPL) an enzyme which degrades lysophospholipids appears in the starchy endosperms and becomes associated with the starch fraction. The enzyme has been reported to have a...
    Resource Type:
    Dissertation
    Full Text:
    approved: Redacted for Privacy (/ Derek J. Baisted The amylose component of cereal starch contains

  • Analysis of cytochrome P-450 isozymes from rat liver and studies on the mechanism of induction

    Creator:
    Williams, David Edward
    Abstract:
    In order to determine the total number of cytochrome P-450 isozymes present in a given species following various treatments, mature male rats (Sprague-Dawley) were injected intraperitoneally with the classic mixed-function oxidase inducers phenobarbital (PB), pregnenolone- 16a-carbonitrile (PCN), 3-methylcholanthrene (3-MC), or the appropriate control vehicle. Hepatic microsomes were solubilized and P-450...
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: Dr. Donald J. Reed In order to determine the total number of cytochrome P-450 iso