Index Catalog // ScholarsArchive@OSU

Interaction of the human Voltage-Dependent Anion Channel 1 protein (VDAC-1) with Mycobacterium avium and its role in bacterial survival within phagocytic cells

Creator:: Pham, Tuan
Abstract:: M. avium is an opportunistic pathogen that primarily infects macrophages. In order to survive within the macrophage, M. avium secretes proteins into the host cell cytoplasm to inhibit specific functions such as phagosome acidification, altering pathways as well as initiating apoptosis. However, little is known about how those secreted proteins...
Resource Type:: Honors College Thesis
Full Text:: wall composed of peptidoglycan (PG) and arabinogalactan (AG) (Brennan and Nikaido 1995) and the

Protein methylation at sites of blood vessel injury

Creator:: Weber, Darin J.
Abstract:: Blood vessel injury was found to release intracellular pools of protein D-aspartyl/L-isoaspartyl carboxyl methyltransferase (PIMT) into the extracellular milieu, where it became trapped. Trapped PIMT was able to utilize radiolabeled S-adenosyl-L-methionine (AdoMet) introduced into the circulation to methylate blood vessel proteins containing altered aspartyl residues specifically at the site of...
Resource Type:: Dissertation
Full Text:: ; Johnson, Murray et al. 1987; Lowenson and Clarke 1992; Brennan and Clarke 1995). The broad substrate

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:: Otto, Shauna C.
Abstract:: Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
Resource Type:: Dissertation

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Creator:: Hooven, Louisa Ada
Abstract:: Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
Resource Type:: Dissertation
Full Text:: . Mark E. Harder. His advice, insight, and steadfast friendship have been invaluable. I wish that I

Characterization of photochemically cross-linked protein-nucleic acid complexes by mass spectrometry

Creator:: Jensen, Ole Norregaard
Abstract:: A novel protocol for the study of protein-nucleic acid interactions is presented and demonstrated to be feasible. The protocol combines photochemical crosslinking techniques and mass spectrometric methods into a new strategy for identifying protein domains or amino acid residues that are in close contact with nucleic acid in protein-nucleic acid...
Resource Type:: Dissertation
Full Text:: -crosslinked protein-nucleic acid complexes: Dr. Mark C. Young and Professor Peter H. von Hippel (University

Understanding Circadian and Light-activated Transcriptional Regulatory Changes During Aging in Drosophila melanogaster

Creator:: Fey, Rosalyn M.
Abstract:: Systems biology is a powerful approach which considers and sheds light on all of the puzzle pieces which make up complex biological processes, and is an effective alternative to unraveling these processes using traditional molecular approaches alone. It is a natural companion approach for computational biology, which leverages the power...
Resource Type:: Dissertation

The analysis and prediction of DNA structure

Creator:: Basham, Beth E.
Abstract:: As genome sequencing projects begin to come to completion, the challenge becomes one of determining how to understand the information contained within the DNA. DNA is a polymorphic macromolecule; the A- B- and Z-DNA conformations have been observed by a variety of physical techniques. The magnitude of the energetic differences...
Resource Type:: Dissertation
Full Text:: evolution and evaluation: Dr. Michael Schimerlik, Dr. Philip McFadden, Dr. Victor Hsu and Dr. Mark

Regulation of ribonucleotide reductase analyzed by simultaneous measurement of the four enzyme activities

Creator:: Hendricks, Stephen P.
Abstract:: The first committed step in DNA biosynthesis occurs by direct reduction of ribonucleotides. This reduction is catalyzed by ribonucleotide reductase (RNR), an enzyme which uses a unique radical mechanism to facilitate the transformation. All four DNA precursors are synthesized by a single enzyme. Therefore, an intricate pattern of regulation has...
Resource Type:: Dissertation
Full Text:: . Hendricks. I thank them with all my heart. I also want to acknowledge my brothers, Thomas P. and Mark P

Dependence of secondary structure of biopolymers on environment : a circular dichroism study of equivocal amino acid sequences in proteins and of left-handed DNA

Creator:: Zhong, Lingxiu
Resource Type:: Dissertation
Full Text:: . Small, for their efforts in guiding my graduate program. I would also like to thank Drs. Mark Harder

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Creator:: Logan, Isabelle E.
Abstract:: Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Resource Type:: Dissertation
Full Text:: Fellowship, the 2019-20 Mark Spoonenburgh LPI Graduate Fellowship, and the 2020-21 Nellie Buck Yerex

ScholarsArchive@OSU

Interaction of the human Voltage-Dependent Anion Channel 1 protein (VDAC-1) with Mycobacterium avium and its role in bacterial survival within phagocytic cells

Protein methylation at sites of blood vessel injury

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Characterization of photochemically cross-linked protein-nucleic acid complexes by mass spectrometry

Understanding Circadian and Light-activated Transcriptional Regulatory Changes During Aging in Drosophila melanogaster

The analysis and prediction of DNA structure

Regulation of ribonucleotide reductase analyzed by simultaneous measurement of the four enzyme activities

Dependence of secondary structure of biopolymers on environment : a circular dichroism study of equivocal amino acid sequences in proteins and of left-handed DNA

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

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