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Extracorporeal Treatment of Hyperuricemia via Enzymatic Functionalized Microchannel Processing Platform (iCore): Experiment and Modeling

Creator:: Pantakitcharoenkul, Jaturavit
Abstract:: Hyperuricemia is the condition of excessive presence of plasma uric acid ≥ 6 mg/dl. Conventional clinical/hospital urate-lowering treatment includes the administration of non-steroid anti-inflammatory drugs or xanthine oxidase inhibitors. Numerous drawbacks can be observed from these conventional treatments. In patients with refractory gout symptoms and tumor lysis syndrome, recombinant uricase...
Resource Type:: Dissertation
Full Text:: of the School of Chemical, Biological and Environmental Engineering Dean of the Graduate

Investigating the Hemocompatibility of Blood-Contacting Biomaterials

Creator:: Hummel, Madeleine H.
Abstract:: Surface-associated thrombosis is a critical concern in medical device development. Current extracorporeal circulation units require systemic anticoagulation to avoid thrombosis, which can cause adverse effects such as thrombocytopenia, hypertriglyceridemia, and hyperkalemia. To address this issue, we combine the technology of polydopamine (PDA) functionalization with slippery liquid infused porous surfaces (SLIPS)....
Resource Type:: Masters Thesis
Full Text:: is common for environmental science and engineering applications, specifically water analysis to

Developmental effects of micro- and nanoscale tire particles and recycled rubber on zebrafish

Creator:: Mottern, Taylor H.
Abstract:: Plastics have become an essential part of everyone lives, found in almost every product made today. Tires only make up a fraction of these products but as their use increasing so does the microplastics that flake off. Many studies have evaluated the toxic effects of tire particles on aquatic environments...
Resource Type:: Honors College Thesis
Full Text:: . Environmental science & technology, 50(2), 924-931. [11]Tian, Z., Zhao, H., Peter, K. T., Gonzalez, M., Wetzel

Phenotyping Degeneration of the Intervertebral Disc with Principal Component Analysis and K-Means Clustering

Creator:: Chen, Joseph
Abstract:: The human intervertebral disc (IVD) provides support for the vertebral bodies, allowing for movement and load bearing. The IVD can degenerate with age or injury, impeding function and causing chronic pain. Despite disc degeneration affecting over 90% of adults over age 50, and back pain being the leading global cause...
Resource Type:: Masters Thesis
Full Text:: degree of Master of Science in Bioengineering presented on June 17, 2022. Title: Phenotyping

Use of ultrasound and magnetic resonance image processing for evaluation of supraspinatus and biceps tendon pathology in dogs

Creator:: Sheikh, Omar
Abstract:: Shoulder injuries, especially those caused by rotator cuff tears, are a pervasive problem in human and canine patients. The ability to quickly and accurately diagnose rotator cuff tears is important for early and targeted treatment. Prior clinical work has demonstrated that ultrasound and magnetic resonance imaging effectively diagnose these tears....
Resource Type:: Masters Thesis
Full Text:: ABSTRACT OF THE THESIS OF Omar Sheikh for the degree of Master of Science in Bioengineering presented on

Biomechanical Modeling of Isometric Muscle-Tendon Force Generation Through Tendons Coupled in Parallel and a Passive Differential Mechanism

Creator:: Le, Anthony H.
Abstract:: There are at least fifteen types of upper extremity tendon transfer procedures for combined peripheral nerve injuries that involve re-routing a single donor muscle to multiple recipient tendons. As a result, force and movement across finger joints become coupled, resulting in limited grasping abilities. Quantification and modeling of the donor...
Resource Type:: Masters Thesis
Full Text:: for the degree of Master of Science in Bioengineering presented on December 10, 2020. Title

Precision Medicine for the Intervertebral Disc: Image Processing and Computational Modeling of Disc Degeneration to Inform Patient-Specific Therapies

Creator:: Ahrens, Sonia R.
Abstract:: The human intervertebral disc is a deceptively simple structure which plays an essential role in human movement. Even slight changes to the disc microenvironment can have far reaching consequences, particularly when these changes result in disc degeneration and herniation. Degeneration is increasingly tied to lower back pain; better understanding this...
Resource Type:: Masters Thesis
Full Text:: degree of Master of Science in Bioengineering presented on March 12, 2021. Title: Precision Medicine

Developing a Modular Analysis Pipeline to Identify Critical Matrisome Components in Gynecological Disease

Creator:: Cook, Carson J.
Abstract:: The matrisome is an ensemble of genes that are highly relevant for characterizing the behavior of the extracellular matrix (ECM) during the onset and progression of many diseases. Recent advances in the definition of the matrisome, such as The Matrisome Project, have been instrumental in making more advanced resources available...
Resource Type:: Masters Thesis
Full Text:: the degree of Master of Science in Bioengineering presented on April 19, 2022. Title: Developing a

Engineering an Ex-Vivo System to Study Transport Phenomena in the Human Intervertebral Disc

Creator:: Shalash, Ward
Abstract:: Back pain is the leading cause of disability worldwide, entailing a significant socioeconomic impact. A primary source of back pain can be attributed to intervertebral disc (IVD) degeneration allowing nerve ingrowth, facet joint arthritis, disc bulging, and osteophyte formations that press on nearby nerve roots or the spinal cord. While...
Resource Type:: Dissertation
Full Text:: & Environmental Engineering Dean of the Graduate School I understand that my dissertation will become part of

Development of Rapid Diagnostic Tools for Personal Health Monitors in the Context of Therapy Monitoring

Creator:: Wentland, Lael T.
Abstract:: Personal health monitoring tools, a subset of point-of care-diagnostics, enable more frequent testing of chronic health conditions outside of a clinic setting and can inform personalized therapy or support telehealth diagnostic capabilities. While there is evidence that regular monitoring of chronic conditions can lead to better health outcomes and lower...
Resource Type:: Dissertation
Full Text:: Bioengineering Head of the School of Chemical, Biological, and Environmental Engineering

ScholarsArchive@OSU

Extracorporeal Treatment of Hyperuricemia via Enzymatic Functionalized Microchannel Processing Platform (iCore): Experiment and Modeling

Investigating the Hemocompatibility of Blood-Contacting Biomaterials

Developmental effects of micro- and nanoscale tire particles and recycled rubber on zebrafish

Phenotyping Degeneration of the Intervertebral Disc with Principal Component Analysis and K-Means Clustering

Use of ultrasound and magnetic resonance image processing for evaluation of supraspinatus and biceps tendon pathology in dogs

Biomechanical Modeling of Isometric Muscle-Tendon Force Generation Through Tendons Coupled in Parallel and a Passive Differential Mechanism

Precision Medicine for the Intervertebral Disc: Image Processing and Computational Modeling of Disc Degeneration to Inform Patient-Specific Therapies

Developing a Modular Analysis Pipeline to Identify Critical Matrisome Components in Gynecological Disease

Engineering an Ex-Vivo System to Study Transport Phenomena in the Human Intervertebral Disc

Development of Rapid Diagnostic Tools for Personal Health Monitors in the Context of Therapy Monitoring

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