Surface-associated thrombosis is a critical concern in medical device development. Current extracorporeal circulation units require systemic anticoagulation to avoid thrombosis, which can cause adverse effects such as thrombocytopenia, hypertriglyceridemia, and hyperkalemia. To address this issue, we combine the technology of polydopamine (PDA) functionalization with slippery liquid infused porous surfaces (SLIPS)....
Artificial lipid bilayer technologies are effective models for studying cell membrane properties. Droplet bilayers rely on microfluidics and provide advantages over other bilayer methods due to their compatibility with automated development systems that increase yield while minimizing cost. This paper describes the implementation of bilayer technologies using membrane protein channels...
Anammox (Anaerobic Ammonium Oxidation) is a significant biogeochemical process carried out by certain bacteria, generally referred to as anammox bacteria. These bacteria have the ability to anaerobically oxidize ammonium (NH4+) with nitrite (NO2-) to form nitrogen gas (N2) without an organic carbon source. While anammox bacteria are found in a...
Back pain is the leading cause of disability worldwide, entailing a significant socioeconomic impact. A primary source of back pain can be attributed to intervertebral disc (IVD) degeneration allowing nerve ingrowth, facet joint arthritis, disc bulging, and osteophyte formations that press on nearby nerve roots or the spinal cord. While...
Sepsis is a blood infection caused by circulating pathogens and cell wall fragments that affects over 1 million patients per year in the United States. When bacterial cell membranes are lysed by antibiotics, cell wall fragments containing lipopolysaccharides (LPS) are released. As a result, the capture of LPS is critical...
The pulse-coupled oscillator model is widely used to simulate the dynamics of neural systems. For networks with particular internal (Mirollo-Strogatz) dynamics, I will define three broad patterns of collective behaviors found in literature in terms of inter-spike interval (ISI) statistics. These patterns are i) temporally-regular, characterized by all oscillators in...
The matrisome is an ensemble of genes that are highly relevant for characterizing the behavior of the extracellular matrix (ECM) during the onset and progression of many diseases. Recent advances in the definition of the matrisome, such as The Matrisome Project, have been instrumental in making more advanced resources available...