Index Catalog // ScholarsArchive@OSU

Investigation of the effects of cryopreservation on cellular viability and mechanical integrity of the intervertebral disc

Creator:: Forcier, Ryan J.
Abstract:: Degeneration of the intervertebral disc (IVD) is a phenomenon that has yet to be adequately addressed. Treatment options remain limited and incomplete. The ability to effectively cryopreserve IVDs would allow for better allograft transplantations and storage of samples for research purposes. This study aimed to assess how cryopreservation with different...
Resource Type:: Honors College Thesis
Full Text:: . Forcier 28 [16] B. J. C. Freeman and J. Davenport, “Total disc replacement in the lumbar spine: a

Predicting Treatment Options for the Intervertebral Disc: Patient-Specific Finite Element Models

Creator:: Ahrens, Sonia R.
Abstract:: This work describes a method for incorporating patient data into a nutrient transport model of the intervertebral disc.This data was collected using MRI diffusion weighted imaging (DWI), and was converted into an apparent diffusion coefficient map (ADC map). This map was used to define the diffusion behavior of water within...
Resource Type:: Honors College Thesis
Full Text:: : _______________________________________________________________________________ Morgan B. Giers This work describes a method for

Mapping Spine Surgical Outcomes and Risk Factors

Creator:: Hernandez, Phillip A.
Abstract:: The majority of people suffer from back pain at some point in their lives. Back pain is the leading cause of disability globally, ahead of 290 other conditions1. Over one million people in the United States receive spine surgery annually2. This thesis looked at five standard surgical procedures performed on...
Resource Type:: Honors College Thesis
Full Text:: Low Back Pain: A Review Article. Asian Spine J. 2020;14(2):245-257. doi:10.31616/asj.2019.0046 6

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Creator:: Laschober, Nicole B.
Abstract:: Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
Resource Type:: Honors College Thesis
Full Text:: release. (A) Dense granule release is enhanced with increased inhibition by MRS2395. (B) Activation

Developing a Modular Analysis Pipeline to Identify Critical Matrisome Components in Gynecological Disease

Creator:: Cook, Carson J.
Abstract:: The matrisome is an ensemble of genes that are highly relevant for characterizing the behavior of the extracellular matrix (ECM) during the onset and progression of many diseases. Recent advances in the definition of the matrisome, such as The Matrisome Project, have been instrumental in making more advanced resources available...
Resource Type:: Masters Thesis
Full Text:: . ©Copyright by Carson J. Cook April 19, 2022 All Rights Reserved Developing a Modular Analysis

Precision Medicine for the Intervertebral Disc: Image Processing and Computational Modeling of Disc Degeneration to Inform Patient-Specific Therapies

Creator:: Ahrens, Sonia R.
Abstract:: The human intervertebral disc is a deceptively simple structure which plays an essential role in human movement. Even slight changes to the disc microenvironment can have far reaching consequences, particularly when these changes result in disc degeneration and herniation. Degeneration is increasingly tied to lower back pain; better understanding this...
Resource Type:: Masters Thesis
Full Text:: Morgan B. Giers The human intervertebral disc is a deceptively simple structure which plays an

Experimental and Mathematical Approaches for Overcoming Mass and Heat Transfer Limitations in Cryopreservation of Vertebral Bodies

Creator:: Forcier, Ryan J.
Abstract:: Successful cryopreservation of bone marrow in situ within vertebral bodies offers an opportunity for quick and convenient storage of a significant quantity of bone marrow stem cells, including hematopoietic- and mesenchymal-type stem cells. However, cryopreservation of more complex large tissues and organs, such as the vertebral body (VB), remains problematic....
Resource Type:: Masters Thesis
Full Text:: …………………………………………………………………………………. 68 A. Chapter 2: CT DMSO Standards ……………………………………………………. 69 B. Chapter 3: Heat Transfer

The Role of Syndecan-1 in Arterial Mechanotransduction.

Creator:: Steyer, Benjamin G.
Abstract:: Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...
Resource Type:: Honors College Thesis
Full Text:: Figure 7. Representative (A) hematoxylin and eosin stained and (B) syndecan-1 immunostained aorta cross

Mathematically modeling transient temperature variation in a human neonate undergoing intensive blue light phototherapy for management of hyperbilirubinemia

Creator:: Gondhalekar, Vikram B.
Abstract:: Neonatal jaundice secondary to hyperbilirubinemia occurs in 60% of all term newborns and nearly all preterm newborns in the US. Severe cases of this may lead to chronic encephalopathy, neurologic deficits, and, in some cases, death. Intensive blue light phototherapy involves irradiation of a patient with high intensity light and...
Resource Type:: Honors College Thesis
Full Text:: variation in a human neonate undergoing intensive blue light phototherapy for management of

Phenotyping Degeneration of the Intervertebral Disc with Principal Component Analysis and K-Means Clustering

Creator:: Chen, Joseph
Abstract:: The human intervertebral disc (IVD) provides support for the vertebral bodies, allowing for movement and load bearing. The IVD can degenerate with age or injury, impeding function and causing chronic pain. Despite disc degeneration affecting over 90% of adults over age 50, and back pain being the leading global cause...
Resource Type:: Masters Thesis
Full Text:: superior and inferior boundaries of the IVD where the vertebral bodies contact the disc (Figure 4 A-B

ScholarsArchive@OSU

Investigation of the effects of cryopreservation on cellular viability and mechanical integrity of the intervertebral disc

Predicting Treatment Options for the Intervertebral Disc: Patient-Specific Finite Element Models

Mapping Spine Surgical Outcomes and Risk Factors

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Developing a Modular Analysis Pipeline to Identify Critical Matrisome Components in Gynecological Disease

Precision Medicine for the Intervertebral Disc: Image Processing and Computational Modeling of Disc Degeneration to Inform Patient-Specific Therapies

Experimental and Mathematical Approaches for Overcoming Mass and Heat Transfer Limitations in Cryopreservation of Vertebral Bodies

The Role of Syndecan-1 in Arterial Mechanotransduction.

Mathematically modeling transient temperature variation in a human neonate undergoing intensive blue light phototherapy for management of hyperbilirubinemia

Phenotyping Degeneration of the Intervertebral Disc with Principal Component Analysis and K-Means Clustering

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