Index Catalog // ScholarsArchive@OSU

Developing a Modular Analysis Pipeline to Identify Critical Matrisome Components in Gynecological Disease

Creator:: Cook, Carson J.
Abstract:: The matrisome is an ensemble of genes that are highly relevant for characterizing the behavior of the extracellular matrix (ECM) during the onset and progression of many diseases. Recent advances in the definition of the matrisome, such as The Matrisome Project, have been instrumental in making more advanced resources available...
Resource Type:: Masters Thesis
Full Text:: . Abstract approved: Kaitlin C. Fogg The matrisome is an ensemble of genes that are

Metabolic Analysis of Bovine Nucleus Pulposus Cells with Constant and Variable Glucose Supply

Creator:: Rosene, Rees Alan
Abstract:: There is no standardized method for culture of intervertebral disc (IVD) cells when monitoring metabolic processes. We hypothesize that the metabolic rates of cells that are crucial to experiment designs depend on the cell culture method used. The glycolytic pathway and the tricarboxylic acid (TCA) cycle are the pathways through...
Resource Type:: Honors College Thesis
Full Text:: Maitre, C. L., Freemont, A. J., & Hoyland, J. A. (2005). The role of interleukin-1 in the pathogenesis

Solvation Effects of Water on Dimethyl Ether Interactions with a Platinum Catalyst

Creator:: Chang, Alvin
Abstract:: Our society today is heavily dependent on fossil fuels such as coal and oil. However, growing environmental concerns and future fossil fuel supplies have led to interests in alternative fuels. Dimethyl Ether (DME) is an inexpensive, clean-burning, non-toxic, and potentially renewable fuel, making it a suitable choice as an alternative...
Resource Type:: Honors College Thesis
Full Text:: . Reaction pathways of C-H dissociation for both systems (with and without water) were also studied using

State-of-the-Art Combination Therapies and Nanomedicines for Triple Negative Breast Cancer

Creator:: Fabbi, Meagan C.
Abstract:: Triple-negative breast cancer (TNBC) is a particularly aggressive molecular subtype of malignant cells that tends to proliferate quickly and is commonly resistant to traditional chemotherapy leading to relapses in prognosis more frequently than other forms of breast cancer (BCa) [1][2][3]. Current treatment options include surgical resection of cancerous tissue and...
Resource Type:: Honors College Thesis
Full Text:: for Triple Negative Breast Cancer By Meagan C. Fabbi A THESIS submitted to Oregon State

Investigating the Potential for Cryopreservation of Human Granulocytes with Concentrated Glycerol

Creator:: Moss, Alden C.
Abstract:: Granulocytes are a class of white blood cells essential to immune function. Granulocyte transfusions hold promise to treat many conditions, but the short-shelf life of granulocytes makes transfusions infeasible without a cell preservation method. The purpose of this study was to investigate the potential for cryopreservation of granulocytes using 30%...
Resource Type:: Honors College Thesis
Full Text:: Glycerol C o n c . (O s m /k g ) Glycerol Removal Step 1: dilute 1:10 in 1.0 molal glycerol

Molecular origins of peptide entrapment within polyethylene oxide brush layers

Creator:: Lampi, Marsha C.
Abstract:: Effective surface coatings for tissue-contacting medical devices should prevent both biofilm formation and infection. One method to achieve this aim is protein repellant polyethylene oxide (PEO) brush coatings loaded with antimicrobials. Previous research has demonstrated that the antimicrobial nisin adsorbs to PEO brush layers in multi-layer amounts and suggests that...
Resource Type:: Honors College Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Marsha C

Developing a membrane leakage assay for the binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2

Creator:: Amsberry, Anthony C.
Abstract:: Sepsis, caused by bacterial release of endotoxin, is a serious blood infection that causes uncontrolled systemic immune response. In North America alone, sepsis kills between 220,000 and 380,000 people each year, more than prostate cancer, breast cancer, and HIV/AIDS combined. Sepsis treatment is complicated and often requires prolonged hospital stays,...
Resource Type:: Honors College Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Anthony C. Amsberry for

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Creator:: Laschober, Nicole B.
Abstract:: Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
Resource Type:: Honors College Thesis
Full Text:: , S. P. Watson, and C. J. Pears, "Submaximal inhibition of protein kinase C restores ADP-induced

Experimental and Mathematical Approaches for Overcoming Mass and Heat Transfer Limitations in Cryopreservation of Vertebral Bodies

Creator:: Forcier, Ryan J.
Abstract:: Successful cryopreservation of bone marrow in situ within vertebral bodies offers an opportunity for quick and convenient storage of a significant quantity of bone marrow stem cells, including hematopoietic- and mesenchymal-type stem cells. However, cryopreservation of more complex large tissues and organs, such as the vertebral body (VB), remains problematic....
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Ryan J. Forcier for

Structural and activity characterization of irradiated antimicrobial peptide (WLBU2) for use in blood processing and biomedical applications

Creator:: Cheung, Daniel Y. C.
Abstract:: Sepsis is a life-threatening blood infection which leads to an uncontrolled systemic inflammatory state. In North America alone, sepsis annually afflicts approximately 750,000 individuals and kills 38-50% of these (more than HIV/AIDS, breast cancer, and colon cancer combined). Current treatment involves administration of IV fluids, antibiotics and hemoperfusion, requiring prolonged...
Resource Type:: Honors College Thesis
Full Text:: were taken with a Jasco (Easton, MD) J- 815 CD spectrometer at 25 °C between 180 and 280 nm with

ScholarsArchive@OSU

Developing a Modular Analysis Pipeline to Identify Critical Matrisome Components in Gynecological Disease

Metabolic Analysis of Bovine Nucleus Pulposus Cells with Constant and Variable Glucose Supply

Solvation Effects of Water on Dimethyl Ether Interactions with a Platinum Catalyst

State-of-the-Art Combination Therapies and Nanomedicines for Triple Negative Breast Cancer

Investigating the Potential for Cryopreservation of Human Granulocytes with Concentrated Glycerol

Molecular origins of peptide entrapment within polyethylene oxide brush layers

Developing a membrane leakage assay for the binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Experimental and Mathematical Approaches for Overcoming Mass and Heat Transfer Limitations in Cryopreservation of Vertebral Bodies

Structural and activity characterization of irradiated antimicrobial peptide (WLBU2) for use in blood processing and biomedical applications

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