Back pain is the leading cause of disability worldwide, entailing a significant socioeconomic impact. A primary source of back pain can be attributed to intervertebral disc (IVD) degeneration allowing nerve ingrowth, facet joint arthritis, disc bulging, and osteophyte formations that press on nearby nerve roots or the spinal cord. While...
Plastic pollution is an ever-increasing environmental threat. As large-scale plastics break down to form nanoscale plastics, it is essential to investigate their effects on freshwater ecosystems. With many plastic nanoparticle (NP) studies favoring the effects of common polystyrene (PS) plastics, a gap is formed for other common plastic types like...
Sepsis is a blood infection that is caused by circulating bacteria cells and cell fragments, which contain immunogenic lipopolysaccharides (LPS) or endotoxin. The circulating endotoxin results in a severe dysregulation of the inflammatory response that ultimately leads to organ failure. One promising treatment method is removal of endotoxin by passing...
Orthopaedic soft tissue degenerative diseases significantly affect the population, especially as it ages. Degeneration is characterized by a progressive loss of extracellular matrix (ECM) components necessary for the proper functioning of the tissues and joints, eventually leading to pain and dysfunction. In humans, the intervertebral disc (IVD) and tendon are...
Diatoms are single celled eukaryotic microalgae that self-assemble complex SiO₂
nanostructures by sillafin proteins within their cell wall. There has been increasing
interest in mimicking the diatom’s silica self-assembly process for fabricating metal
oxide nanoparticles, namely germanium dioxide (GeO₂). GeO₂ has a higher refractive
index than silica, enabling it to...
The matrisome is an ensemble of genes that are highly relevant for characterizing the behavior of the extracellular matrix (ECM) during the onset and progression of many diseases. Recent advances in the definition of the matrisome, such as The Matrisome Project, have been instrumental in making more advanced resources available...
Our society today is heavily dependent on fossil fuels such as coal and oil. However, growing environmental concerns and future fossil fuel supplies have led to interests in alternative fuels. Dimethyl Ether (DME) is an inexpensive, clean-burning, non-toxic, and potentially renewable fuel, making it a suitable choice as an alternative...
Nowadays, woody biomass is becoming increasingly significant because of its renewability and biodegradability. Lots of opportunities have been found to use excessive biological resources to derive products as diverse as fuels, heat, electricity, chemicals, food, clothing, paper, and much more. As such, biomass plays an important role in meeting demands...
The human intervertebral disc is a deceptively simple structure which plays an essential role in human movement. Even slight changes to the disc microenvironment can have far reaching consequences, particularly when these changes result in disc degeneration and herniation. Degeneration is increasingly tied to lower back pain; better understanding this...
Electrochemical sensing provides a quantitative alternative to colorimetric reactions within paper-based devices. The paper-based devices were fabricated by screen printing the conductive and reference inks onto porous substrates that were evaluated using cyclic voltammetry. Devices were evaluated based on the magnitude of the average anodic peak height, which correlates with...