Index Catalog // ScholarsArchive@OSU

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:: Snyder, Kevin M.
Abstract:: In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...
Resource Type:: Masters Thesis
Full Text:: THESIS OF Kevin M. Snyder for the degree of Master of Science in Chemistry presented on May 17, 2016

Computational Investigation and Prediction of Mechanisms and Stereocontrol in Complex Organic Reactions

Creator:: Pattawong, Ommidala
Abstract:: Complex organic transformations, such as the addition of pyrrole to ketene using planar chiral organocatalyst (*PPY), the four-component anhydride- Manniach reactions, and the site-selective desymmetrization of meso-1,2-diol, are remarkable synthetic reactions that provide high yield and high selectivity. However, the exact mechanism and origins of stereocontrol for theses synthetic organic...
Resource Type:: Dissertation
Full Text:: the four representative DAEHs. Christopher M. Beaudry and Paul Ha-Yeon Cheong contributed in part to

Atropisomeric 8,8'-biquinolyl derivatives : synthesis, properties and applications

Creator:: Milicevic, Selena D.
Abstract:: 7,7'-Dihydroxy-8,8'-biquinolyl (azaBINOL) was prepared from 7-hydroxyquinoline via N,N-dimethyl O-quinol-7-yl carbamate by directed ortho-metallation followed by FeCl₃-mediated oxidative coupling of the 8-lithioquinoline intermediate. Saponification of the resulting dicarbamate provided crystalline (±)-azaBINOL in 56% overall yield. 6,6'-Bis(dimethylaminocarbonyl)-7,7'-dihydroxy-8,8´-biquinolyl was prepared from the same dicarbamate by a double anionic-Fries rearrangement in 43% yield. 7,7'-Bis(diethylamino-carbonyloxy)-6,6'-diiodo-8,8´-biquinolyl...
Resource Type:: Dissertation
Full Text:: Paul R. Blakemore 7,7´-Dihydroxy-8,8´-biquinolyl (azaBINOL) was prepared from 7-hydroxyquinoline

Stereoselective synthesis & application of enantioenriched main group α-haloalkyl organometal reagents

Creator:: Emerson, Christopher R.
Abstract:: Sulfoxide-ligand exchange (SLE) and asymmetric halogen-metal exchange (AHME) processes were separately examined for the enantioselective synthesis of functionalized alpha-haloalkylmetal (carbenoid) reagents. Carbenoids derived from SLE were used to effect stereospecific reagent-controlled homologation (StReCH) of boronic esters and those generated via AHME were engaged in Darzens-type chemistry with aldehydes. Abstract for...
Resource Type:: Dissertation
Full Text:: .#=)&"$,+ + + RRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRR+ L#/-+%3+".#+6$/07/"#+!(.%%'+ + + + M+7-0#$&"/-0+"./"+=,+0)&&#$"/")%-+T)''+@#(%=#+2/$"+%3

Catalytic desymmetrization of D₂d̳-symmertic proprochiral tetrasubstituted biphenyl compounds: a novel approach to the synthesis of axially chiral C₂-symmetric molecules

Creator:: Gunderson, Jeremey Tyson
Abstract:: Many D2d-symmetric 2,2',6,6'-tetrasubstituted biphenyls are readily prepared via net oxidative dimerization of appropriate 1,3-disubstituted benzenes. Conversion of such proprochiral compounds to useful C2-symmetric chiral biphenyls requires formal replacement of two substituents on opposing aryl ring units with alternate groups. This under exploited desymmetrization tactic has been demonstrated for the generation...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: Paul R. Blakemore Many D2d-symmetric 2,2',6,6'-tetrasubstituted biphenyls are

Investigation of Chain Extension Approaches for the Stereoselective Reagent-Controlled Synthesis of alpha-Heteroatom Substituted Alkyl Boronic Esters

Creator:: Barsamian, Adam L.
Abstract:: Two distinct strategies were explored for the enantioselective synthesis of α-heteroatom substituted alkyl boronic esters by stereoselective reagent-controlled homologation using transient chiral carbenoid reagents CHYMX (Y = heteroatom, X = nucleofuge, M = electrofuge). In the first case, a stereospecific reagent-controlled homologation (sStReCH) approach to α-alkoxyalkylboronates using α-metalated S,O- and...
Resource Type:: Dissertation
Full Text:: . Paul R. Blakemore Two distinct strategies were explored for the enantioselective synthesis of α

Searching for new niobium oxide based superconductors

Creator:: Bacon, Paul Eric
Resource Type:: Masters Thesis
Full Text:: ABSTRACT OF THE THESIS OF Paul Eric Bacon for the degree of Master of Science in Chemistry presented on

Thermodynamics of the reaction between F and M centers in KBr

Creator:: Li, Tsai-chi
Resource Type:: Masters Thesis
Full Text:: Thermodynamics of the reaction between F and M centers

Using Computational and Statistical Methods as an Aid to Study Environmentally Relevant Organic Molecules

Creator:: Dorn, Shelby E.
Abstract:: In this report, three studies are presented that utilize computations to predict transformations, identities, and properties of environmental organic molecules. Each study shows how computations can lead to models of chemical behavior. The importance of this research is rooted in the need for understanding how human behavior and health intersect...
Resource Type:: Masters Thesis
Full Text:: Molecules. Abstract approved: ______________________________________________________ Paul Ha

Nutritional muscular dystrophy production and pectoral muscle 5'-nucleotidase activity in the chick

Creator:: Roffler, Sheila Ann
Abstract:: In an attempt to find a laboratory species which develops an experimental myopathy similar to white muscle disease (WMD) in lambs, comparative studies of nutritional muscular dystrophy of chicks were initiated. This condition was grossly visible as white striations running parallel with the fibers of the pectoral muscles and was...
Resource Type:: Masters Thesis
Full Text:: the M.S. m __Bi:_o~~e~~s~r_ _ (Name) (Degree) (Major) Date thesis is presented_ #/..l/.;~3_1

ScholarsArchive@OSU

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Computational Investigation and Prediction of Mechanisms and Stereocontrol in Complex Organic Reactions

Atropisomeric 8,8'-biquinolyl derivatives : synthesis, properties and applications

Stereoselective synthesis & application of enantioenriched main group α-haloalkyl organometal reagents

Catalytic desymmetrization of D₂d̳-symmertic proprochiral tetrasubstituted biphenyl compounds: a novel approach to the synthesis of axially chiral C₂-symmetric molecules

Investigation of Chain Extension Approaches for the Stereoselective Reagent-Controlled Synthesis of alpha-Heteroatom Substituted Alkyl Boronic Esters

Searching for new niobium oxide based superconductors

Thermodynamics of the reaction between F and M centers in KBr

Using Computational and Statistical Methods as an Aid to Study Environmentally Relevant Organic Molecules

Nutritional muscular dystrophy production and pectoral muscle 5'-nucleotidase activity in the chick

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