Index Catalog // ScholarsArchive@OSU

Aiding Plants and Humans by Targeting Virulence Strategies: Investigation of key protein residues involved in toxoflavin production

Creator:: Justen, Savannah F.
Abstract:: Toxoflavin, a toxic secondary metabolite produced by a variety of bacteria, has been implicated as a causative agent in food poisoning and a virulence factor in phytopathogenic bacteria. This toxin is produced by the tox operon in Burkholderia glumae, in which the encoded protein, ToxD, was previously characterized as essential...
Resource Type:: Honors College Thesis
Full Text:: approved: Benjamin Philmus Toxoflavin, a toxic secondary metabolite produced by a variety of bacteria

Isolation and Identification of Indole Metabolites from Pseudomonas fluorescens NZI7

Creator:: Vergis, John M.
Abstract:: Pseudomonas fluorescens NZI7 was first isolated from a New Zealand mushroom farm in 2001. This Gram-negative bacteria can cause brown blotch disease in the basidiomycete mushroom Agaricus bisporus. P. fluorescens NZI7 can also repel grazing by the nematode Caenorhabditis elegans, a natural predator of P. fluorescens NZI7. Potentially implicated in...
Resource Type:: Honors College Thesis
Full Text:: ______________________________________________________________ Benjamin Philmus, Committee Member, representing Pharmaceutical Sciences

Total Synthesis of Cephalotaxus Alkaloids and Synthetic Studies toward Bazzanin K

Creator:: Ju, Xuan
Abstract:: Dearomatization reactions exist broadly in biosynthesis and chemical synthesis. The highly functionalized atoms of arenes can be masked by it aromaticity, and upon dearomatization, those reactive atoms can be readily applied to bond formation and further manipulation. The total synthesis of (–)-cephalotaxine and (–)- homoharringtonine is described via an oxidative...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Christopher M. Beaudry Dearomatization reactions exist broadly in biosynthesis and chemical

Gas-phase fragmentation chemistry of protonated peptide ions

Creator:: Bythell, Benjamin James
Abstract:: The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions...
Resource Type:: Dissertation
Full Text:: 2 AN ABSTRACT OF THE DISSERTATION OF Benjamin James Bythell for the degree of Doctor of

Analytical method development for the identification, detection, and quantification of emerging environmental contaminants in complex matrices

Creator:: Place, Benjamin J.
Abstract:: The development of analytical methods for emerging contaminants creates many unique challenges for analytical chemists. By their nature, emerging contaminants have inherent data gaps related to their environmental occurrence, fate, and impact. This dissertation is a compilation of three studies related to method development for the structural identification of emerging...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Benjamin

Electroluminescent and photoluminescent phosphor development and a facile approach to synthesis of refractory silicates at low temperatures

Creator:: Clark, Benjamin L.
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Benjamin L. Clark for the degree of Doctor of Philosophy in Chemistry presented on May 3

The apparent molal volume of salts in methanol solution

Creator:: Stark, John Benjamin
Resource Type:: Masters Thesis
Full Text:: 0.1? SALTS IN METHANOL SOLUTION by JOHN BENJAMIN STARK A THESIS su.bmitte to the OREGON

Scaffold reactivity and large scale Synthesis of organocatalyzed Yamada-Otani Condensation product and investigation of the synthesis and properties of axially chiral 8,8'-biquinolyls and 8-(naphtha-1-yl)quinolines

Creator:: Banerjee, Somdev
Abstract:: In Part I, (4S,5R)-4,5-dimethyl-4-phenylcyclohex-2-enone (19a) was prepared in 73% yield with high enantio- and diastereo-selectivity (er > 98:2, dr > 20:1) on a multigram scale by a Yamada-Otani condensation between (E)-pent-3-en-2-one and 2-phenylpropanal catalyzed by a sulfonimide derivative of (S)-proline (18, HuaCat®). Synthetically useful transformations of the cyclohexenone product 19a...
Resource Type:: Dissertation
Full Text:: significant bioactivity with respective IC50 = 4.74 μM and 5.18 μM for inhibition of HIV-1 entry into TZM-b1

Synthetic Studies towards Highly Oxygenated Furanyl Diterpenoids

Creator:: Goswami, Subir
Abstract:: The furanyl diterpenoid family of natural products has drawn the attention of both synthetic organic chemists and pharmacologists due to their complex structural architectures and diverse biological activity. Among them, wortmannin has been most extensively studied for biological activities. All these furanyl diterpenoids consist of a highly strained naptha[1,8-bc]furan core,...
Resource Type:: Dissertation
Full Text:: . Chem. 2005, 3, 2053-2061. [2] (a) Roll, D. M.; Scheuer, P. J.; Matsumoto, G. K.; Clardy, J. J. Am

Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

Creator:: Adpressa, Donovon A.
Abstract:: Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
Resource Type:: Dissertation
Full Text:: .; Pierce, B.R.; Smith, K.M.; Freitag, M.; Loesgen, S. “Overexpression and Discovery of New Secondary

ScholarsArchive@OSU

Aiding Plants and Humans by Targeting Virulence Strategies: Investigation of key protein residues involved in toxoflavin production

Isolation and Identification of Indole Metabolites from Pseudomonas fluorescens NZI7

Total Synthesis of Cephalotaxus Alkaloids and Synthetic Studies toward Bazzanin K

Gas-phase fragmentation chemistry of protonated peptide ions

Analytical method development for the identification, detection, and quantification of emerging environmental contaminants in complex matrices

Electroluminescent and photoluminescent phosphor development and a facile approach to synthesis of refractory silicates at low temperatures

The apparent molal volume of salts in methanol solution

Scaffold reactivity and large scale Synthesis of organocatalyzed Yamada-Otani Condensation product and investigation of the synthesis and properties of axially chiral 8,8'-biquinolyls and 8-(naphtha-1-yl)quinolines

Synthetic Studies towards Highly Oxygenated Furanyl Diterpenoids

Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

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