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Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Creator:: Veerasamy, Nagarathanam
Abstract:: The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
Resource Type:: Dissertation
Full Text:: members cernuine (1.14)18c,21a,b and cermizine D (1.13).18c,21,22 This quinolizidine scaffold is also

Precursor-directed Biosynthesis and Total Synthesis of Aniline-containing Natural Products from the Endophytic Fungus Chalara sp. 6661

Creator:: Khoshbakht, Mahsa
Abstract:: Chalaniline A, an unusual xanthone-like aminofulvene with modest cytotoxicity, and chalaniline B [1-anilino-2,8-dihydroxy-3-(hydroxymethyl)xanthone], an antibacterial aminoxanthone, were previously isolated by Loesgen and coworkers from vorinostat-treated Chalara sp. 6661. Of note, the anilino moiety found within both chalaniline structures originates from biotransformation of the HDAC inhibitor vorinostat (SAHA, suberanilohydroxamic acid) by...
Resource Type:: Dissertation
Full Text:: unusual xanthone-like aminofulvene with modest cytotoxicity, and chalaniline B [1-anilino-2,8-dihydroxy

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Creator:: Neuhaus, George F.
Abstract:: The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
Resource Type:: Dissertation
Full Text:: 2009, 17, 4022. (11) Carvalho, I. T.; Estevinho, B. N.; Santos, L. International Journal of Cosmetic

Phenolic oxidative coupling : an approach to the synthesis of pretazettine

Creator:: Chong, Wesley Kwan Mung
Abstract:: Various hypervalent iodine compounds were evaluated as reagents for intramolecular phenolic oxidative coupling. It was found that phenyliodine(III) bis(trifluoroacetate) was effective for the coupling of the monophenolic substrate 13a to 14a under neutral conditions. Vanadium oxytrifluoride and hypervalent iodine compounds were compared as oxidants for the conversion of 32 to...
Resource Type:: Dissertation
Full Text:: unnatural, cis B-D ring fusion stereochemistry in this ring closure was ascertained by nuclear mag- netic

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:: Huang, Lin
Abstract:: Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
Resource Type:: Dissertation
Full Text:: -unsaturated hydroxyalkenal, and b) levuglandins, a group of isomeric γ-ketoaldehydes. We tested the

Development of Miniature Wire pH Sensors for Real-Time Monitoring of the Streptococcus Mutans Biofilm

Creator:: Wong, Derek C.
Abstract:: The interface between a biofilm and the underlying substrate to which it is attached is challenging to study. Currently, available methods of studying this microenvironment have not been able to record data in real-time over a time period in the range of days. To address this challenge, we report the...
Resource Type:: Honors College Thesis
Full Text:: References 1. Dye, B.; Thornton-Evans, G.; Li, X.; Iafolla, T., Dental caries and tooth loss in adults in

Evidence for a stepwise mechanism in the cycloreversion of rhenium diolates

Creator:: Ness, Stephanie L.
Resource Type:: Masters Thesis

Analysis of fourteen trace elements in Saudi Arabian layered gabbros by radiochemical neutron activation analysis

Creator:: Palmer, Curtis Allyn
Abstract:: Eight layered gabbro samples from two layered complexes, two xenoliths, one basalt from a hot brine area and a standard basalt rock (BCR-1) were analyzed by RNAA (radiochemical neutron activation analysis) for 14 trace elements, Au, Ni, Co, Ag, Sb, Se, Zn, In, T1, Rb, Cs, U, Ba and Sr....
Resource Type:: Masters Thesis
Full Text:: Reactor A B C D F G Sb tracer, Ba tracer, Sr tracer Jt 26A, 226A, BCR-1, Au Std., Co-Ni Std. JT

Synthesis and SERS : Reproducible Nanostar Plasmons and a Study of Optical Enhancement

Creator:: Ramsey, Jacob D.
Abstract:: Gold nanostars are a relative newcomer to the nanoparticle scene, and their unique properties make them very desirable for spectroscopic applications. These nanoparticles, with their sharp tips, create electric field enhancements that interact with light in an advantageous way. This Thesis outlines our in-depth study of gold nanostar synthesis, the...
Resource Type:: Honors College Thesis
Full Text:: 1(b) and 2). At 25 °C the width of the spectral profile at three quarters full maximum ranged

Deposition and characterization of transition metal oxides from aqueous solution

Creator:: Betterton, Sharon A.
Abstract:: The aqueous chemistries of two transition metal cations, Zr⁴⁺ and Nb⁵⁺, are examined and then used to develop inorganic precursor solutions. The oxides of these cations (ZrO₂ and Nb₂O₅) are deposited and characterized, and their morphological and optical properties discussed. Due to the obstacles created by niobium's aqueous chemistry, an...
Resource Type:: Masters Thesis
Full Text:: , Cauchy parameters A, B, and C, and mean square error (MSE) ....................................... 32

ScholarsArchive@OSU

Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Precursor-directed Biosynthesis and Total Synthesis of Aniline-containing Natural Products from the Endophytic Fungus Chalara sp. 6661

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Phenolic oxidative coupling : an approach to the synthesis of pretazettine

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Development of Miniature Wire pH Sensors for Real-Time Monitoring of the Streptococcus Mutans Biofilm

Evidence for a stepwise mechanism in the cycloreversion of rhenium diolates

Analysis of fourteen trace elements in Saudi Arabian layered gabbros by radiochemical neutron activation analysis

Synthesis and SERS : Reproducible Nanostar Plasmons and a Study of Optical Enhancement

Deposition and characterization of transition metal oxides from aqueous solution

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