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  • Preparation of Tacrolimus-loaded Biodegradable Nanoparticles for Sustained Drug Delivery

    Creator:
    Kinser, Reid
    Abstract:
    Tacrolimus is an immunosuppressant drug approved by the FDA for the prevention of organ transplant rejection. However, the use of this drug is hindered by its narrow therapeutic window and extreme insolubility in water. Due to these properties, the currently used tacrolimus preparations must be administered once or twice daily...
    Resource Type:
    Honors College Thesis
    Full Text:
    Oregon State University University Honors College in partial fulfillment of

  • Aging and oxidative damage to mitochondrial membrane proteins

    Creator:
    Tong, Tony T.
    Abstract:
    Mitochondria provide energy for biological cells to function, but this process is also a source of oxygen radicals that are capable of damaging nearby proteins. Mitochondrial protein damage can eventually lead to cell death, especially in the case of heart cells, where mitochondria are present in the highest concentrations. As...
    Resource Type:
    Honors College Thesis
    Full Text:
    Oregon State University University Honors College in partial fulfillment of the requirements for the

  • Evaluation of Oxidation Reduction Potential in Metabolic Syndrome Subjects Compared with Matched Normal Subjects

    Creator:
    Cobb, Tora Jean
    Abstract:
    This study was conducted to assess whether healthy adults compared with those with Metabolic Syndrome (MetS) have different mean oxidative-reductive potentials. Static oxidation-reduction potentials and capacity oxidation reduction potentials (sORP and cORP, respectively) were measured in plasma samples. The RedoxSYS® measures sORP in millivolts (mV), which is proportional to the...
    Resource Type:
    Honors College Thesis
    Full Text:
    A THESIS submitted to Oregon State University University Honors College

  • Toad Populations Decreasing in South Korea

    Creator:
    Chung, Yun Soo
    Abstract:
    Massive die-offs of Bufo bufo gargarizans were observed in May 2008 in Mangwal Gee, Korea. To find out the causes for this disaster several different elements were examined: pH, total nitrogen, dissolved oxygen (DO), and dissolved heavy metal, suspension, introduced species, habitat change, disease, temperature changes, and precipitation and humidity....
    Resource Type:
    Honors College Thesis
    Full Text:
    , University Honors College I understand that my project will become part of the permanent

  • Systematic Review of Prevalence, Risks, and Cultural Differences of Fractures and Falls Among Hispanic Communities

    Creator:
    Chitwood, Abigail
    Abstract:
    In the United States, falls are the leading cause of fractures and accidental death in the elderly; 70% of these fractures are women. Hispanic women account for a large population in the US, however data on falls and fractures for these women is lacking. The purpose of this systematic review...
    Resource Type:
    Honors College Thesis
    Full Text:
    University Honors College in partial fulfillment of the requirements for the degree of

  • Design and Fabrication of a Polymeric Microfluidic Device for Automated

    Creator:
    Warner, Kelsie E.
    Abstract:
    Gene synthesis is an important tool in molecular biology. However, the current bench-top method of gene synthesis is a costly, time-intensive and reagent-consuming process. Lab-on-chip technology has many benefits over current bench top methods. Microchips consume smaller reagent volumes, are reusable and less expensive to make. This thesis explores the...
    Resource Type:
    Honors College Thesis
    Full Text:
    Oregon State University University Honors College in partial fulfillment of the requirements for

  • Effects of Estrogen Receptor Blockade on Skeletal Response to Alcohol in Ovariectomized Rats

    Creator:
    Wagner, Lindsay A.
    Abstract:
    Heavy alcohol consumption reduces peak bone mass in growing rodents and can lead to bone loss in both adult rats and humans. In contrast, moderate alcohol consumption appears to have a bone sparing effect in post-menopausal women. Alcohol has been reported to increase aromatase activity and influence estrogen receptor (ER)...
    Resource Type:
    Honors College Thesis
    Full Text:
    submitted to Oregon State University University Honors College in partial fulfillment of the

  • Development of micro-wire solid-state sensors for the real-time detection of metabolites at the Streptococcus mutans biofilm-biomaterial interface

    Creator:
    Aponso, Savinda
    Abstract:
    We have developed a 100 m diameter solid-state potentiometric pH sensor to study the bacterial metabolism at the biofilm-biomaterial interface in real-time. The newly developed agar-coated pH sensor is both highly resistant to biofouling and stable, with a drift of 1 mV/h in physiological conditions. We used multiwall carbon nanotubes...
    Resource Type:
    Honors College Thesis
    Full Text:
    University Honors College in partial fulfillment of the requirements for the

  • High Resolution Spectroscopy of Bicyclo[1.1.1]pentane

    Creator:
    Martin, Matthew A.
    Abstract:
    The strained carbon ring, bicyclo[1.1.1]pentane, was synthesized by a reaction between 1-(phenylsulfanyl)bicyclo[1.1.1]pentane, prepared from propellane, and Raney nickel. Infrared spectra were recorded at a resolution of 0.0015 cm-1, a resolution significantly better than previous measurements, 0.06 cm-1. A single fundamental band was analyzed to determine the ground state and excited...
    Resource Type:
    Honors College Thesis
    Full Text:
    submitted to Oregon State University University Honors College in partial fulfillment of the

  • Reorientation in Alternative Break Trips

    Creator:
    Phillips, Caitlin Patricia
    Abstract:
    When a student participates in a service break trip, a process called reorientation occurs after the trip is over, when the student is trying to connect what they’ve learned on the trip to their normal lives. The objective of this project was to explore the concepts of volunteerism, community service,...
    Resource Type:
    Honors College Thesis
    Full Text:
    submitted to Oregon State University University Honors College in partial fulfillment