The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...
Three distinct methods to achieve the stereoselective synthesis of carbon-carbon bonds were investigated, encompassing: (i) the formation of axially chiral biaryl molecules by enantioselective Suzuki cross-coupling, (ii) the synthesis of α-phenylalkylboronic esters by enantioselective chain extension, and (iii) the stereospecific synthesis of alkenes by eliminative cross-coupling of enantioenriched sp³-hybridized carbenoids....
It has been reported that cyanide inactivates the succinate dehydrogenase activity of HMP toward cytochrome c, oxygen, methylene blue and DCIP. In the present study, it was found that cyanide
also solubilizes the SDH from HMP, this is reflected by the extent
of solubilization of acid nonextractable flavin in the...
The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
Investigating the structure-property relationships of solid state materials can help improve many of the materials we use each day in life. It can also lead to the discovery of materials with interesting and unforeseen properties. In this work the structure property relationships of newly discovered layered oxypnictide phases are presented...
In this dissertation, I present electronic spectroscopy of a few biologically relevant species and their complexes with solvent molecules in the gas phase using a variety of techniques, including resonantly enhanced multiphoton ionization (REMPI), laser induced fluorescence (LIF), and zero kinetic energy (ZEKE) photoelectron spectroscopy. My work on several methylated...
In this dissertation, I present electronic spectra of a few polycyclic aromatic hydrocarbons (PAHs): tetracene, pentacene, pyrene, benzo[g,h,i]perylene and benzo[a]pyrene using resonantly enhanced multiphoton ionization (REMPI) and zero kinetic energy (ZEKE) photoelectron spectroscopy. The work of tetracene and pentacene also combine a laser desorption source with a ZEKE spectrometer, demonstrating...
New synthetic strategies have been investigated for nano-dimensioned
graphite particles or even isolated graphene sheets. One approach is to prepare
graphite intercalation compounds (GICs) with low layer charge density and
appropriate gallery height, followed by the colloidal dispersion or exfoliation of the
resulting GICs. A series of anions has been...
In the 21st century, environmental deterioration is now an indisputable fact. Reliable and economically viable electricity systems based on renewable sources are urgently needed to replace the environmentally detrimental fossil fuels. The feasibility of incorporating renewable-but-intermittent solar and wind energy heavily depends on the development of cost-effective and safe technologies,...