Index Catalog // ScholarsArchive@OSU

Harnessing the Potential of Gut Microbiome in the Context of Type 2 Diabetes

Creator:: Gurung, Manoj
Abstract:: Gut microbiota plays an essential role in health and diseases, a fact already established. With the explosive increase in obesity and its main complication, Type 2 Diabetes Mellitus (T2D), there is an immediate need for novel methods of diagnosis, prevention and treatment of these conditions. In the last one and...
Resource Type:: Dissertation
Full Text:: K and L cells of the enteroendocrine system of the intestine. GIP is a potent insulinotropic

Crossing Boundaries during Stress Responses: Antigen Presentation by Adaptive and Innate MHC Class I Molecules

Creator:: Nagamine, Brandy S.
Abstract:: The immune system is a complex network of cellular processes working in harmony to guard us against pathogenic attack. Of utmost importance is the ability of the immune system to discriminate between “self” and “non-self” and diseased versus healthy. Recognition of antigens complexed to major histocompatibility complex (MHC) molecules is...
Resource Type:: Dissertation
Full Text:: -527. 3. Dai, H. H., P. X. Lan, D. Q. Zhao, K. Abou-Daya, W. T. Liu, W. H. Chen, A. J. Friday, A. L

Inter- and Intra-rater Reliability and Agreement in Determining Tumor Margins and Inter-surgeon Agreement in Determining 3 cm Surgical Margins of Subcutaneous Tumors in Dogs

Creator:: Ranganathan, Bharadhwaj
Abstract:: Determination of the gross edge of a tumor is required during patient staging, assessing response to therapy, and for planning and executing surgical resection of locally invasive neoplasms. Disagreement in determination of the gross edge of the tumor is likely to directly affect patient staging, assessing response to therapy and...
Resource Type:: Masters Thesis
Full Text:: Chapter 3. Townsend K – Co-investigator, assisted in project design, data acquisition, manuscript

Prevalence of Deficiency and Relationship of Management Practices to Vitamin E and Selenium Status in Horses

Creator:: Pitel, Mariya O.
Abstract:: Deficiency of selenium (Se) or alpha-tocopherol (E) creates serious health issues in horses. This study evaluated owner supplementation practices and their efficacy at preventing deficiency in a large population of horses. In addition, common clinical signs of horses presenting to a referral institution who had Se and E testing performed...
Resource Type:: Masters Thesis

The Role of Tumor-Derived Exosomes in the Development of Carboplatin Resistance in Canine Osteosarcoma

Creator:: Weinman, Marcus
Abstract:: Many humans and canines alike suffer from osteosarcoma, which is often metastatic, resistant to chemotherapy, and frequently fatal. The mechanisms through which osteosarcoma cells acquire resistance to chemotherapy are not entirely understood, and the role of exosomes as intercellular mediators of this resistance in osteosarcoma is unknown. Using established canine...
Resource Type:: Masters Thesis

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Creator:: Sackinger, Emily P.
Abstract:: Alzheimer’s Disease (AD) is an abnormal part of aging that mainly affects those over the age of 65. The current therapies are only FDA approved for mild to moderate AD symptoms. Cannabidiol (CBD) is a non-intoxicating constituent of Cannabis sativa that has been shown to have beneficial effects on cancer,...
Resource Type:: Masters Thesis

Using the Microbial Tree of Life to Describe Mammalian Health and Disease

Creator:: Arnold, Holly Kristin
Abstract:: The past decade of research has potentiated a revolution in our understanding of mammalian health and evolution by revealing that the gut microbiome plays a central role in mammalian physiology. Our ability to unlock this potential hinges upon the identification of specific groups of gut microbes that elicit effects on...
Resource Type:: Dissertation
Full Text:: Chapter 2: Gaulke, C. A., Arnold, H. K., Humphreys, I. R., Kembel, S. W., O’dwyer, J. P., & Sharpton, T

Establishing a Humanized Microbiota Mouse Model of CVID-Enteropathy

Creator:: You, Hyekyoung Hannah
Abstract:: Common variable immunodeficiency (CVID) is the most common primary immunodeficiency that is characterized by low immunoglobulin levels in the body. CVID is indicated by failure of b cell differentiation and decrease production of immunoglobulins such as IgG and at least one of IgA or IgM. CVID patients with enteropathy (E-CVID)...
Resource Type:: Masters Thesis
Full Text:: with rat IgG (Jackson ImmunoResearch) and stained with the following antibodies: Viability APC 780

Identification of Mycobacterium smegmatis Surface Proteins for Stimulation of Anti-Mycobacterial Killing Activity of Macrophages

Creator:: Islam, Sabrina
Abstract:: Mycobacterium avium subspecies hominissuis (M. avium) is a ubiquitous, acid-fast organism found in water and soil. This opportunistic pathogen is a common causative of pulmonary diseases in immunocompromised individuals and prevalent infection in HIV/AIDS patients. As a primary defense response against infection, immune cells such as macrophages phagocytize M. avium...
Resource Type:: Masters Thesis

Inclusion Fusion and Genetic Recombination: Bridging the Gap Between the Chlamydiae

Creator:: Garvin, Lotisha E.
Abstract:: Chlamydia is an obligate intracellular bacterial pathogen that causes a variety of disease in animals and humans worldwide. Veterinary chlamydial pathogens can lead to chronic infections and serious consequences that result in millions of dollars of losses in animals and resources in the agricultural industry in countries that rear ruminants....
Resource Type:: Dissertation
Full Text:: ocular trauma leading to blindness. Serovars D-K are urogenital strains, most commonly infecting the

ScholarsArchive@OSU

Harnessing the Potential of Gut Microbiome in the Context of Type 2 Diabetes

Crossing Boundaries during Stress Responses: Antigen Presentation by Adaptive and Innate MHC Class I Molecules

Inter- and Intra-rater Reliability and Agreement in Determining Tumor Margins and Inter-surgeon Agreement in Determining 3 cm Surgical Margins of Subcutaneous Tumors in Dogs

Prevalence of Deficiency and Relationship of Management Practices to Vitamin E and Selenium Status in Horses

The Role of Tumor-Derived Exosomes in the Development of Carboplatin Resistance in Canine Osteosarcoma

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Using the Microbial Tree of Life to Describe Mammalian Health and Disease

Establishing a Humanized Microbiota Mouse Model of CVID-Enteropathy

Identification of Mycobacterium smegmatis Surface Proteins for Stimulation of Anti-Mycobacterial Killing Activity of Macrophages

Inclusion Fusion and Genetic Recombination: Bridging the Gap Between the Chlamydiae

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