Index Catalog // ScholarsArchive@OSU

Virulent Mycobacterium avium subspecies Hominissuis Subverts Macrophages during Early Stages of Infection

Creator:: Ndzeidze, Robert F.
Abstract:: Interference with the host post-translational mechanisms, such as protein phosphorylation, is a key strategy used by many intracellular bacterial pathogens to subvert host immune cell function. Virulent non-tuberculous Mycobacteria (NTMs) unlike attenuated or non-pathogenic NTMs, successfully reside and multiply within the phagosomes of phagocytic cells such as monocytes and macrophages....
Resource Type:: Masters Thesis
Full Text:: . M., Lee, J. Y., Kim, K. H., Shin, S. J., Takahara, K., Lee, S. J., & Jo, E. K. (2008

Characterization of Membrane Vesicles Released by the Opportunistic Human Pathogen Mycobacterium avium subsp. hominissuis (MAH) in Response to an in vitro System Mimicking the Phagosomal Environment

Creator:: Chiplunkar, Sanket S.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) belongs to the most-clinically significant non-tuberculous mycobacterial (NTM) pathogens with constant increase in disease prevalence, mainly in several industrialized western countries where tuberculosis is less prevalent. Upon entry into the alveolar space, MAH is engulfed by resident-macrophages, where the pathogen adapts to the hostile phagosomal...
Resource Type:: Masters Thesis

The Role of Tumor-Derived Exosomes in the Development of Carboplatin Resistance in Canine Osteosarcoma

Creator:: Weinman, Marcus
Abstract:: Many humans and canines alike suffer from osteosarcoma, which is often metastatic, resistant to chemotherapy, and frequently fatal. The mechanisms through which osteosarcoma cells acquire resistance to chemotherapy are not entirely understood, and the role of exosomes as intercellular mediators of this resistance in osteosarcoma is unknown. Using established canine...
Resource Type:: Masters Thesis

Proteomic Profiles of Circulating Exosomes as Biomarkers for Disease Detection in Canine Osteosarcoma

Creator:: Brady, Jacqueline V.
Abstract:: Osteosarcoma (OSA) is the most common primary skeletal tumor in dogs accounting for 85% of bone tumors and nearly 6% of all canine neoplasms. They are highly aggressive tumors that carry a poor prognosis despite intensive treatment, highlighting the need for more effective diagnostic and therapeutic tools. Recent research in...
Resource Type:: Masters Thesis

Crossing Boundaries during Stress Responses: Antigen Presentation by Adaptive and Innate MHC Class I Molecules

Creator:: Nagamine, Brandy S.
Abstract:: The immune system is a complex network of cellular processes working in harmony to guard us against pathogenic attack. Of utmost importance is the ability of the immune system to discriminate between “self” and “non-self” and diseased versus healthy. Recognition of antigens complexed to major histocompatibility complex (MHC) molecules is...
Resource Type:: Dissertation
Full Text:: . 30. Kim, Y. K., J. S. Shin, and M. H. Nahm. 2016. NOD-Like Receptors in Infection, Immunity, and

The immunomodulatory role of canine mesenchymal stem cell-derived extracellular vesicles

Creator:: Phelps, Shannon M.
Abstract:: Immune-mediated diseases are a frequent cause of morbidity and mortality in canine patients. Treatments currently involve generalized suppression of the immune system, and corticosteroids are often used as a first-line agent. While often effective, corticosteroids are unlikely to induce remission without substantial side effects. Second-line immunosuppressive agents may be effective...
Resource Type:: Masters Thesis

Pseudoloma neurophilia in the Zebrafish (Danio rerio) : Consequences of Infection on Neurobehavioral and Biomedical Research using a Burgeoning Model Organism

Creator:: Spagnoli, Sean
Abstract:: Since its inception as a laboratory animal in the early 1970s, the zebrafish has proven itself a rising star in the world of comparative biomedical sciences due to its short generation time, ease of care, external fertilization, and transparent larvae. In a very few decades, the zebrafish has been utilized...
Resource Type:: Dissertation

Prospective Evaluation of the Lymph Node Proteome in Dogs with Multicentric Lymphoma Supplemented with Sulforaphane

Creator:: Parachini-Winter, Cyril
Abstract:: Lymphoma (LSA) is one of the most common canine malignancies, and is almost invariably a terminal disease. Epigenetic changes in canine and human lymphomas have been linked to disease progression and poor prognosis, leading to the development of epigenetic-targeted therapies which have shown promise in treating various forms of human...
Resource Type:: Masters Thesis

Using the Microbial Tree of Life to Describe Mammalian Health and Disease

Creator:: Arnold, Holly Kristin
Abstract:: The past decade of research has potentiated a revolution in our understanding of mammalian health and evolution by revealing that the gut microbiome plays a central role in mammalian physiology. Our ability to unlock this potential hinges upon the identification of specific groups of gut microbes that elicit effects on...
Resource Type:: Dissertation

ScholarsArchive@OSU

Virulent Mycobacterium avium subspecies Hominissuis Subverts Macrophages during Early Stages of Infection

Characterization of Membrane Vesicles Released by the Opportunistic Human Pathogen Mycobacterium avium subsp. hominissuis (MAH) in Response to an in vitro System Mimicking the Phagosomal Environment

The Role of Tumor-Derived Exosomes in the Development of Carboplatin Resistance in Canine Osteosarcoma

Proteomic Profiles of Circulating Exosomes as Biomarkers for Disease Detection in Canine Osteosarcoma

Crossing Boundaries during Stress Responses: Antigen Presentation by Adaptive and Innate MHC Class I Molecules

The immunomodulatory role of canine mesenchymal stem cell-derived extracellular vesicles

Pseudoloma neurophilia in the Zebrafish (Danio rerio) : Consequences of Infection on Neurobehavioral and Biomedical Research using a Burgeoning Model Organism

Prospective Evaluation of the Lymph Node Proteome in Dogs with Multicentric Lymphoma Supplemented with Sulforaphane

Using the Microbial Tree of Life to Describe Mammalian Health and Disease

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