Index Catalog // ScholarsArchive@OSU

The Role of Tumor-Derived Exosomes in the Development of Carboplatin Resistance in Canine Osteosarcoma

Creator:: Weinman, Marcus
Abstract:: Many humans and canines alike suffer from osteosarcoma, which is often metastatic, resistant to chemotherapy, and frequently fatal. The mechanisms through which osteosarcoma cells acquire resistance to chemotherapy are not entirely understood, and the role of exosomes as intercellular mediators of this resistance in osteosarcoma is unknown. Using established canine...
Resource Type:: Masters Thesis
Full Text:: osteosarcoma risk, such as Li-Fraumeni syndrome, Hereditary Retinoblastoma, Rothmund-Thompson Syndrome, and

Crossing Boundaries during Stress Responses: Antigen Presentation by Adaptive and Innate MHC Class I Molecules

Creator:: Nagamine, Brandy S.
Abstract:: The immune system is a complex network of cellular processes working in harmony to guard us against pathogenic attack. Of utmost importance is the ability of the immune system to discriminate between “self” and “non-self” and diseased versus healthy. Recognition of antigens complexed to major histocompatibility complex (MHC) molecules is...
Resource Type:: Dissertation
Full Text:: . Williams, T. Sun, J. J. Chen, W. Chen, S. Mortin-Toth, J. S. Danska, C. Wiebe, P. Nickerson, T. F. Li, L

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Creator:: Sackinger, Emily P.
Abstract:: Alzheimer’s Disease (AD) is an abnormal part of aging that mainly affects those over the age of 65. The current therapies are only FDA approved for mild to moderate AD symptoms. Cannabidiol (CBD) is a non-intoxicating constituent of Cannabis sativa that has been shown to have beneficial effects on cancer,...
Resource Type:: Masters Thesis
Full Text:: elevate extrasynaptic glutamate levels (Z. C. Wang, Zhao, & Li, 2013), which could lead to an increase

Identification of Mycobacterium smegmatis Surface Proteins for Stimulation of Anti-Mycobacterial Killing Activity of Macrophages

Creator:: Islam, Sabrina
Abstract:: Mycobacterium avium subspecies hominissuis (M. avium) is a ubiquitous, acid-fast organism found in water and soil. This opportunistic pathogen is a common causative of pulmonary diseases in immunocompromised individuals and prevalent infection in HIV/AIDS patients. As a primary defense response against infection, immune cells such as macrophages phagocytize M. avium...
Resource Type:: Masters Thesis
Full Text:: provided by Xin-tian Li, National Institutes of Health, Frederick, Maryland) was used for chromosomal

Quantitative Analysis of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus subs. abscessus Proteome in Response to Antibiotics and During Exposure to Different Environmental Conditions

Creator:: Rojony, Rajoana
Abstract:: M. avium subsp. hominissuis (MAH) and M. abscessus subsp. abscessus (MAB) both belong to the clinically important non-tuberculous mycobacterial (NTM) group that infect immunocompromised patients with AIDS and individuals with underlining lung conditions such as bronchiectasis or cystic fibrosis. The main challenge of treating MAH and MAB patients is an...
Resource Type:: Masters Thesis

Bacterial and Host Factors Contributing to Mycobacterium avium subspecies paratuberculosis Persistent Infection

Creator:: Phillips, Ida L.
Abstract:: Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s disease, a chronic granulomatous enteritis that plagues domestic and wild ruminants globally. During the silent stages of Johne’s disease, infected animals intermittently shed bacteria for years prior to clinical diagnosis during advanced disease stages. This strategy allows MAP to...
Resource Type:: Dissertation

Virulent Mycobacterium avium subspecies Hominissuis Subverts Macrophages during Early Stages of Infection

Creator:: Ndzeidze, Robert F.
Abstract:: Interference with the host post-translational mechanisms, such as protein phosphorylation, is a key strategy used by many intracellular bacterial pathogens to subvert host immune cell function. Virulent non-tuberculous Mycobacteria (NTMs) unlike attenuated or non-pathogenic NTMs, successfully reside and multiply within the phagosomes of phagocytic cells such as monocytes and macrophages....
Resource Type:: Masters Thesis
Full Text:: . Bannantine, J. P., Zhang, Q., Li, L. L., & Kapur, V. (2003). Genomic homogeneity between Mycobacterium avium

Harnessing the Potential of Gut Microbiome in the Context of Type 2 Diabetes

Creator:: Gurung, Manoj
Abstract:: Gut microbiota plays an essential role in health and diseases, a fact already established. With the explosive increase in obesity and its main complication, Type 2 Diabetes Mellitus (T2D), there is an immediate need for novel methods of diagnosis, prevention and treatment of these conditions. In the last one and...
Resource Type:: Dissertation
Full Text:: my co-authors and labmates, Dr. Richard Rodrigues, Dr. Zhipeng Li, Stephany Vasquez-Perez, Hannah

Proteomic Profiles of Circulating Exosomes as Biomarkers for Disease Detection in Canine Osteosarcoma

Creator:: Brady, Jacqueline V.
Abstract:: Osteosarcoma (OSA) is the most common primary skeletal tumor in dogs accounting for 85% of bone tumors and nearly 6% of all canine neoplasms. They are highly aggressive tumors that carry a poor prognosis despite intensive treatment, highlighting the need for more effective diagnostic and therapeutic tools. Recent research in...
Resource Type:: Masters Thesis

Increasing Vitamin D Levels to Improve Fertilization Rates in Cattle

Creator:: Peixoto de Souza, Vanessa
Abstract:: Recently, an interest in supplementation of vitamin D to improve aspects of health, especially in human fertility, has emerged. However, supplementation of Vitamin D above the minimum required levels to prevent deficiency has yet to be explored in cattle despite evidence for vitamin D receptors in reproductive tissues. The objective...
Resource Type:: Masters Thesis

ScholarsArchive@OSU

The Role of Tumor-Derived Exosomes in the Development of Carboplatin Resistance in Canine Osteosarcoma

Crossing Boundaries during Stress Responses: Antigen Presentation by Adaptive and Innate MHC Class I Molecules

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Identification of Mycobacterium smegmatis Surface Proteins for Stimulation of Anti-Mycobacterial Killing Activity of Macrophages

Quantitative Analysis of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus subs. abscessus Proteome in Response to Antibiotics and During Exposure to Different Environmental Conditions

Bacterial and Host Factors Contributing to Mycobacterium avium subspecies paratuberculosis Persistent Infection

Virulent Mycobacterium avium subspecies Hominissuis Subverts Macrophages during Early Stages of Infection

Harnessing the Potential of Gut Microbiome in the Context of Type 2 Diabetes

Proteomic Profiles of Circulating Exosomes as Biomarkers for Disease Detection in Canine Osteosarcoma

Increasing Vitamin D Levels to Improve Fertilization Rates in Cattle

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