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Filtering by: Creator Fitzpatrick, Martin S. Remove constraint Creator: Fitzpatrick, Martin S. Degree Field Microbiology Remove constraint Degree Field: Microbiology

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  • Bioinformatics applied to freshwater cyanobacterial blooms and cyanophage

    Creator:
    Schwartz, Andrew D.
    Abstract:
    Freshwater cyanobacterial blooms are a nuisance and health threat in the Pacific Northwest. The accepted methods of characterizing these blooms by microscopic cell counts cannot differentiate between toxic and non-toxic strains of the cyanobacterium Microcystis. Also, there is limited understanding of freshwater cyanophage that may control bloom dynamics. In order...
    Resource Type:
    Masters Thesis
    Full Text:
    . Dreher Frederick S. Colwell Freshwater cyanobacterial blooms are a nuisance

  • Study on the Evolution and Expression of the Pyoverdine Receptor FpvA inPseudomonas aeruginosa

    Creator:
    Singh, Amandip
    Abstract:
    Pseudomonas aeruginosa is a ubiquitous gram-negative bacterium that is capable of causing infections in people who are immune compromised. The bacterium can live in a variety of environments due to the variety of virulence factors it can produce. It is well adapted to living in iron-stringent conditions because it can...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Martin Schuster Pseudomonas aeruginosa is a ubiquitous gram-negative bacterium that is

  • Studies on the evolution and expression of the Type II ferripyoverdine receptor gene fpvAIIb in Pseudomonas aeruginosa

    Creator:
    Glover, Rochelle
    Abstract:
    When iron levels are low, the opportunistic pathogen Pseudomonas aeruginosa secretes the high-affinity iron-binding siderophore pyoverdine. The cognate ferripyoverdine receptor, FpvA, has gained attention as the most divergent gene in the organism’s genome, showing substantial evidence of positive selection. S-type pyocins, bacteriocins with specificity to Pseudomonads, enter cells through FpvA...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Abstract approved: ______________________________________________________ Martin Schuster When

  • The Fitness Costs and Regulatory Strategies of Cooperative Siderophore Production in Pseudomonas

    Creator:
    Sexton, David
    Abstract:
    Cooperative behaviors in bacteria are increasingly appreciated for their relevance to microbial ecology and utility as model systems for social evolution. One example is the secretion of siderophores, a structurally diverse group of compounds that chelate extracellular iron. Siderophore production is considered cooperative because the benefits can be shared with...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: Martin Schuster Cooperative behaviors in bacteria are increasingly

  • Quorum sensing gene regulation in Pseudomonas aeruginosa

    Creator:
    Gupta, Rashmi
    Abstract:
    Pseudomonas aeruginosa is an opportunistic human pathogen that infects immunocompromised individuals such as those suffering from burns or the genetic disorder cystic fibrosis. This organism utilizes a cell-cell communication mechanism known as quorum sensing (QS) to coordinate virulence gene expression and biofilm formation. It has three interconnected QS systems, namely...
    Resource Type:
    Dissertation
    Full Text:
    : Quorum Sensing Gene Regulation in Pseudomonas aeruginosa. Abstract approved: Martin Schuster

  • Evolution of a streamlined cooperator in Pseudomonas aeruginosa quorum sensing

    Creator:
    Huie, Jessica L.
    Abstract:
    Social behavior leading to the production of common goods is prone to exploitation. One such behavior in Pseudomonas aeruginosa is quorum sensing (QS), by which the bacteria produce signals to regulate extracellular common goods. Exploitation comes in the form of cheaters which have a mutation in the central quorum sensing...
    Resource Type:
    Masters Thesis
    Full Text:
    Quorum Sensing Abstract approved: Martin Schuster Social behavior leading to the

  • Social Evolution and Regulatory Architecture of Pseudomonas aeruginosa Quorum Sensing

    Creator:
    Asfahl, Kyle L.
    Abstract:
    Cell-cell communication in bacteria is understood to facilitate the coordination of population-wide cooperative behavior in the form of concerted gene expression. The opportunistic pathogen Pseudomonas aeruginosa uses such a communication mechanism to regulate a large group of genes important to virulence strategies in this bacterium. This general mechanism of communication...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: ______________________________________________________ Martin Schuster

  • The Social Interactions of Pseudomonas aeruginosa

    Creator:
    Smith, Parker
    Abstract:
    Pseudomonas aeruginosa is a ubiquitous environmental microbe, opportunistic pathogen, and a highly social organism. P. aeruginosa utilizes a wide array of cooperative behaviors to adapt to the environmental conditions around it. These behaviors include quorum sensing (QS), a form a cell-to-cell signaling that coordinates the expression of secreted products in...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Martin Schuster Pseudomonas aeruginosa is a ubiquitous environmental microbe

  • Analysis of Mutations Affecting Cooperation in Pseudomonas aeruginosa Populations

    Creator:
    Robinson, Tanner M.
    Abstract:
    In a process called quorum sensing (QS), the bacterial pathogen Pseudomonas aeruginosa uses small diffusible signals to coordinate cooperative behaviors via secreted “public goods”. Under QS-dependent growth conditions, social cheaters arise with mutations in lasR, the gene for the primary QS signal receptor. These cheaters do not produce public goods....
    Resource Type:
    Masters Thesis
    Full Text:
    : ______________________________________________________ Martin Schuster In a process called quorum sensing (QS), the bacterial pathogen Pseudomonas

  • Characterization of Quorum-Sensing Diversity in Environmental Pseudomonas aeruginosa Populations

    Creator:
    Grellmann, Elise Kaylene
    Abstract:
    While the quorum-sensing (QS) diversity of the opportunistic pathogen Pseudomonas aeruginosa has been well established in cystic fibrosis (CF) lung infections and in vitro experiments, little is known about its QS-diversity in natural environments. One significant QS-deficient behavior is social cheating. Social cheaters contain mutations that prevent them from producing...
    Resource Type:
    Honors College Thesis
    Full Text:
    aeruginosa Populations. Abstract approved: Martin Schuster While the quorum-sensing (QS