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Filtering by: Creator Makarova, Kira S. Remove constraint Creator: Makarova, Kira S. Degree Field Microbiology Remove constraint Degree Field: Microbiology

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  • Establishment and dynamics of methane-oxidizing microbial communities in marine sediments

    Creator:
    Klasek, Scott A.
    Abstract:
    Marine sediments are vast sources and reservoirs of methane, a potent greenhouse gas. Most of this methane is anaerobically oxidized by archaea before it can reach the overlying ocean, though the efficiency of this process often depends on methane fluxes and mechanisms of fluid transport. Anaerobic methanotrophic archaea, or ANME,...
    Resource Type:
    Dissertation
    Full Text:
    : ____________________________________________________________ Frederick S. Colwell Abstract Marine sediments are vast sources and reservoirs of methane

  • Comparative Genomics of Freshwater Bloom-Forming Cyanobacteria and Associated Organisms

    Creator:
    Driscoll, Connor B.
    Abstract:
    The advent of improved DNA sequencing technologies has allowed the analysis of various microbial communities. Bloom-forming freshwater cyanobacteria can produce toxins and taste-and-odor compounds that can negatively affect drinking water supplies. Here, I have employed second- and third-generation sequencing technologies to characterize bloom-forming freshwater cyanobacterial genomes and their associated heterotrophic...
    Resource Type:
    Dissertation
    Full Text:
    . . . . . . . . . . . . . . 52 3.1 Genome information. *’s denote novel genomes . . . . . . . . . . . 86 3.2 Novel genomes

  • Identification of Small Molecule Inhibitors of the Staphylococcus aureus Sortase A Enzyme

    Creator:
    Bateman, Katherine B.
    Abstract:
    The Sortase A (SrtA) enzyme is a potential target for a new class of anti-infective drugs because it is responsible for anchoring virulence factors to the surface of pathogenic, Gram-positive bacteria such as Staphylococcus aureus. High throughput screening yielded low molecular weight compounds that inhibit purified SrtA from S. aureus....
    Resource Type:
    Honors College Thesis
    Full Text:
    that inhibit purified SrtA from S. aureus. The efficacy of these compounds at targeting SrtA in live

  • Advances in Freshwater Cyanobacterial Genomics

    Creator:
    Brown, Nathaniel M.
    Abstract:
    Limnology is undergoing a transition to high-throughput -omic analysis of freshwater bacterial communities. An important first step in making the transition is to characterize several genomes that can be used as references to guide metagenome assembly and analysis. Here I characterize four new freshwater cyanobacterial genomes, a pair of lake...
    Resource Type:
    Dissertation
    Full Text:
    . . . . . . . . . . . . . . . . . . . 98 5.2.2 S-CRS01 infects Cyanobium sp. LC18 . . . . . . . . . . . . . 99 5.2.3 The C-CRS01 genome

  • Chromosomal Recombination Targets in Chlamydial Lateral Gene Transfer In Vitro

    Creator:
    Kim, Debbie Blue
    Abstract:
    Background: Lateral gene transfer (LGT) among C. trachomatis strains is common, both in isolates generated in the laboratory and those examined directly from patients. This is a challenging concept because there are very few examples of recent acquisition of foreign DNA by Chlamydia spp. There is no understanding of the...
    Resource Type:
    Honors College Thesis
    Full Text:
    sequences for RC1673’s LM of recombination. The 50th base pair was established from the 1st base pair

  • Characterization of novel exopolysaccharide producing lactic acid bacteria

    Creator:
    Garcia, Roberto A., III
    Abstract:
    Lactic Acid Bacteria (LAB), an important group of organisms in modern food production, are known to secrete a unique compound called exopolysaccharide (EPS). EPS is economically important because it enhances functional properties in food and may confer beneficial health effects to consumers. Novel strains of Lactococcus lactis, Streptococcus thermophilus, and...
    Resource Type:
    Masters Thesis
    Full Text:
    thermophilus R-39.…………...……55 Transfer epsN gene from L. lactis Ropy 352 to S. thermophilus R-39………58

  • Genetic and biochemical studies in the genus Bacillus

    Creator:
    Beaty, Jon Stuart
    Resource Type:
    Dissertation
    Full Text:
    ) and S-adenosylmethionine (SAM). 2 Subsequently, such enzymes have been found to occur in many di

  • Genetic variation of chlamydial Inc proteins

    Creator:
    Viratyosin, Wasna
    Abstract:
    Genomic analysis is a new approach for the characterization and investigation of novel genes, gene clusters, the function of uncharacterized proteins, and genetic diversity in microorganisms. These approaches are important for the study of chlamydiae, a system in which several genomes have been sequenced but in which techniques for genetic...
    Resource Type:
    Dissertation
    Full Text:
    9. Fluorescence microscopy of McCoy cells infected with a serovar J(s) 69 variant of Chiamydia

  • Clostridium perfringens sporulation and gliding motility

    Creator:
    Huang, I-Hsiu
    Abstract:
    Clostridium perfringens type A isolates, an anaerobic enterotoxigenic spore forming bacterium, are the third leading cause of food-borne disease in the United States. Factors that contribute to the virulence of C. perfringens include the ability of the bacterium to form heat resistant spores and to produce an enterotoxin (CPE). Although...
    Resource Type:
    Dissertation
    Full Text:
    of myxobacteria utilize two engines, referred to as A (adventurous) and S (social) (60). S

  • Molecular and genetic assessment of selected antiporters and methyl-accepting chemotaxis proteins in Vibrio cholerae

    Creator:
    Quinn, Matthew J.
    Abstract:
    The pathogen Vibrio cholerae uses cations as a primary currency of virulence and environmental persistence, using gradients of those cations to move, acquire nutrients, and control virulence gene expression. An understanding of the overlapping roles of bioenergetics and chemotaxis in the virulence and environmental survival of V. cholerae issues from...
    Resource Type:
    Dissertation