Index Catalog // ScholarsArchive@OSU

The Response to Sulforaphane in Metastatic Prostate Cancer Cells

Creator:: Watson, Gregory
Abstract:: Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
Resource Type:: Dissertation

Regulation by male-specific fruitless of neural circuitry used during courtship and copulation behavior in Drosophila melanogaster

Creator:: Latham, Kristin Lynn
Abstract:: Courtship and copulation behaviors in Drosophila melanogaster males are regulated by sex-specific products from the gene fruitless (fru). Male-specific FRU proteins (FRU[superscript M]) are putative transcription factors of the BTB-ZnF family that likely act by controlling development and maintenance of the neural circuitry used during male sexual behavior. However, which...
Resource Type:: Dissertation
Full Text:: , as well as Jeff Hall at Brandeis and members of his lab: Adriana Villella, Gyunghee Lee, and Troy

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Creator:: Knecht, Andrea L.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
Resource Type:: Dissertation
Full Text:: ), cardiopulmonary mortality (Lewtas 2007; Lee, Magari et al. 2011) and lung cancer mortality (Hoshuyama, Pan et

Characterization of Neurospora crassa and Fusarium graminearum mutants defective in repeat-induced point mutation

Creator:: Pomraning, Kyle R.
Abstract:: Mutation of repetitive DNA by repeat-induced point mutation (RIP) is a process that occurs in many filamentous fungi of the Ascomycota during the sexual cycle. Concurrently, direct DNA repeats are often deleted by homologous recombination at high frequency during the sexual cycle. Thus, the processes of RIP and deletion compete...
Resource Type:: Dissertation

The role of keratinocytic RXRα in regulating melanocyte homeostasis and carcinogen induced melanomagenesis, The role of keratinocytic RXR[alpha] in regulating melanocyte homeostasis and carcinogen induced melanomagenesis

Creator:: Hyter, Stephen D.
Abstract:: Cutaneous melanoma remains the deadliest form of skin cancer, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. Previous studies determined that mice selectively lacking the nuclear hormone...
Resource Type:: Dissertation
Full Text:: ; Miyata et al., 1998; Lee and Wei, 1999). The large numbers of regulatory factors, as well as tissue

Investigating Protein-lipid-membrane Interactions in Plant Cells using Bimolecular Fluorescence Complementation

Creator:: Tao, Kai
Abstract:: The overall focus of this thesis is on the distribution of specific lipids and membrane proteins of the external and internal membranes of plant cells, in the context of the roles that those lipids and proteins may play in microbe-plant interactions. The work includes the development of several new tools,...
Resource Type:: Dissertation
Full Text:: in labs, Wei Zhao, Danyu Shen, Linkai Cui, Meng Cai, Biao Gu, Jianqiang Miao, Tingquan Wu. I also

Genomic Resource Development for European Hazelnut (Corylus avellana L.)

Creator:: Rowley, Erik R.
Abstract:: European hazelnut (Corylus avellana L.) is an important crop Oregon's Willamette Valley, producing 99% of the hazelnuts grown in North America and brings over US $60 million dollars to the region annually. Hazelnuts are rich in fiber and vitamins, as well in demand by consumers due to their popularity as...
Resource Type:: Dissertation

Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

Creator:: Fei, Xiaobo
Abstract:: Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
Resource Type:: Masters Thesis

Prostate cancer prevention with broccoli : from cellular to human studies

Creator:: Clarke, John D.
Abstract:: Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
Resource Type:: Dissertation

Dissecting the cytoskeletal interaction during cytokinesis and the role of myosin II motors on homologous chromosomes

Creator:: Tseng, Kuo-Fu
Abstract:: Prior to cell cleavage, cytokinetic proteins are recruited into the nascent actomyosin contractile ring. Interactions between spindle microtubules and the cell cortex play a critical role in this recruitment. However, direct evidence for physical interaction between microtubules and the cortex has been lacking. Here we reveal the physical connection between...
Resource Type:: Dissertation
Full Text:: example, the nondisjunction of human chromosome 21, will lead to Down Syndrome (Shen et al., 1998

ScholarsArchive@OSU

The Response to Sulforaphane in Metastatic Prostate Cancer Cells

Regulation by male-specific fruitless of neural circuitry used during courtship and copulation behavior in Drosophila melanogaster

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Characterization of Neurospora crassa and Fusarium graminearum mutants defective in repeat-induced point mutation

The role of keratinocytic RXRα in regulating melanocyte homeostasis and carcinogen induced melanomagenesis, The role of keratinocytic RXR[alpha] in regulating melanocyte homeostasis and carcinogen induced melanomagenesis

Investigating Protein-lipid-membrane Interactions in Plant Cells using Bimolecular Fluorescence Complementation

Genomic Resource Development for European Hazelnut (Corylus avellana L.)

Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

Prostate cancer prevention with broccoli : from cellular to human studies

Dissecting the cytoskeletal interaction during cytokinesis and the role of myosin II motors on homologous chromosomes

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