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  • Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

    Creator:
    McNamara, Michael J.
    Abstract:
    Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
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    Dissertation
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    to more thoroughly characterize the surface-exposed proteome of M. avium, particularly in the

  • Proteomic analyses of marine bacteria

    Creator:
    Sowell, Sarah M.
    Abstract:
    Proteins are the metabolic machines of the cell and as such, the study of proteins could illuminate the dominant biological activities that are occurring within cells and reveal how an organism interacts with its environment. Here, we used proteomic techniques to study the abundant marine bacterium SAR11 both as an...
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    Dissertation
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    devoting significant resources to proteome remodeling. A mechanism for a global stationary-phase response

  • Alternative splicing in the obligate biotrophic oomycete pathogen, Pseudoperonospora cubensis

    Creator:
    Cumbie, Jason S.
    Abstract:
    Oomycetes are some of the most devastating pathogens, causing upwards of billions of dollars of damage each year to plants. They also diminish ecological diversity and health through the destruction of trees and shrubs. The genome sequence of Pseudoperonospora cubensis, an obligate plant pathogen and causative agent of downy mildew...
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    Dissertation
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    transcriptome and proteome complexity to influence gene regulation and phenotypic plasticity. Because of the

  • Transcriptional networks controlled by the fatty acid regulators FAR-1 and FAR-2

    Creator:
    Bredeweg, Erin L.
    Abstract:
    Fungi are capable of growth on a wide variety of carbon sources, both living and dead. They can produce an arsenal of enzymes and transporters for harvesting sugars, polysaccharides, amino acids, lipids and micronutrients from their environments [1]. Within the nucleus of a cell, transcription factors (TF) control whether genes...
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    !relative!abundance!of!proteins!within!the!cell!or! “proteome”!can!have!broad!effects!from!redirection!of

  • The Response to Sulforaphane in Metastatic Prostate Cancer Cells

    Creator:
    Watson, Gregory
    Abstract:
    Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
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    found that sulforaphane does not lead to a global remodeling of the proteome following sulforaphane

  • Transcriptomic Analyses of Crop Plants using Next-Generation Sequencing Technology

    Creator:
    Geniza, Matthew J.
    Abstract:
    Advancements in molecular biology and computer science have enabled researchers the ability to investigate the transcriptome – the quantification of an organism’s RNA transcripts in response to its environment on a system wide scale. The collective chapters of this thesis utilize high-throughput RNA sequencing, which produces hundreds of millions of...
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    Dissertation
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    Jaiswal Advancements in molecular biology and computer science have enabled researchers the

  • The proteomic and transcriptomic responses to iron, sulfur, and nitrogen limitation in the abundant marine bacterium Candidatus Pelagibacter ubique

    Creator:
    Smith, Daniel P.
    Abstract:
    Batch cultures of Candidatus Pelagibacter ubique were grown under iron-, organosulfur-, and nitrogen-limiting conditions to understand how this ubiquitous marine bacterium responds to and interacts with environments where growth is limited by the availability of these nutrients. Global gene expression was monitored using microarrays and quantitative mass spectrometry to observe...
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    Dissertation
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    and computer science into a manageable undergraduate program was made possible by my bioresource

  • The aging endoplasmic reticulum

    Creator:
    Dixon, Brian M.
    Abstract:
    Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
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    experience – not necessarily the science herein, although I hope you’ll find that sound as well, but rather

  • Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

    Creator:
    Creason, Allison L.
    Abstract:
    Plant pathogenic Rhodococcus species are persistent pathogens able to cause severe growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted by current models to synthesize a mixture of cytokinins that act to directly perturb the hosts' hormone balances, which results in abnormal...
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    Dissertation
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    .............................................................................................. 228 Appendix II: Temporal profiling of the Arabidopsis plasma membrane proteome and transcriptome

  • An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

    Creator:
    Manchanda, Aayushi
    Abstract:
    Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
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    , and Dr Christiane Loehr for all their helpful suggestions that made my science better. To my BB and