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Filtering by: Creator Chow, A. Remove constraint Creator: Chow, A. Degree Field Pharmaceutical Sciences Remove constraint Degree Field: Pharmaceutical Sciences

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  • Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

    Creator:
    DuRoss, Allison N.
    Abstract:
    The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
    Resource Type:
    Dissertation
    Full Text:
    nanoparticles, however, represent only a small class of nanomaterials that may be impactful in the field of

  • Development and implementation of a transkingdom network analysis pipeline to identify drivers of disease

    Creator:
    Newman, Nolan K.
    Abstract:
    The gut microbiome has been previously implemented in a number of diseases. Of note is its substantial role in metabolic syndrome, which encapsulates a group of conditions that increase the risk of cardiovascular disease, type 2 diabetes, and stroke. Understanding the causal relationships between the gut microbiome and host processes...
    Resource Type:
    Dissertation
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    . Title: Development and Implementation of a Transkingdom Network Analysis Pipeline to Identify Drivers

  • Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

    Creator:
    Carpenter, Evan L.
    Abstract:
    Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
    Resource Type:
    Dissertation
    Full Text:
    ., keratinocytes). However, melanocytes encounter a large burden of oxidative stress during this process, due to

  • Application of Bootstrap Methods in Bioequivalence Studies for Oral Generic Prodrug Products

    Creator:
    Li, Wenjing
    Abstract:
    The methodology to perform bioequivalence studies for prodrug products has not been finalized by FDA leaving the investigators to speculate over the proper approach. This study innovatively utilized the bootstrap methods for testing in vivo bioequivalence on both parent drug and metabolite of four prodrug products: Clopidogrel, Prednisone, Allopurinol, and...
    Resource Type:
    Dissertation
    Full Text:
    Bioequivalence Studies for Oral Generic Prodrug Products by Wenjing Li A DISSERTATION

  • Gene Networks of the Skeletal Muscle Cell

    Creator:
    Singh, Arun J.
    Abstract:
    Skeletal muscle is the largest organ in the body by mass, comprising roughly 40% of total bodyweight in adults. It plays diverse and unique roles that include movement, locomotion, and support for posture and internal organs, among others. The structural foundation for all skeletal muscle in adults is formed early...
    Resource Type:
    Dissertation
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    limited to what was thought to be a myogenic lineage. Additionally, coexpression network analysis

  • Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

    Creator:
    Paraiso, Ines L.
    Abstract:
    Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
    Resource Type:
    Dissertation
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    is a complex multifactorial disease resulting from excessive energy intake compared to energy

  • Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

    Creator:
    Axton, Elizabeth R.
    Abstract:
    Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
    Resource Type:
    Dissertation
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    : ____________________________________________________ Jan F. Stevens and Robert Tanguay Nitric oxide (NO) is a signaling molecule that regulates

  • Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

    Creator:
    Baarda, Benjamin I.
    Abstract:
    Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...
    Resource Type:
    Dissertation
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    resistance is diminishing the ability to effectively treat a disease with significant consequences to

  • Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

    Creator:
    Kim, Jeonghwan
    Abstract:
    Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
    Resource Type:
    Dissertation
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    the murine nasal cavity. Next, we tried to stabilize LNPs during aerosolization by a