Index Catalog // ScholarsArchive@OSU

Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

Creator:: Albarqi, Hassan Ahmad M.
Abstract:: Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
Resource Type:: Dissertation
Full Text:: Alani, Gaurav Sahay, and Ling Jin for serving on my thesis committee and their guidance. Special

Drug Discovery and Chemical Ecology Investigations of Specialized Metabolism in Tolypocladium and Paraisaria

Creator:: Tehan, Richard M.
Abstract:: Since the discovery of penicillin in 1928, the fungal kingdom has remained a fertile source for the discovery of new, biologically active, natural products. Further, as natural products continue to be discovered from fungi, a deeper understanding of the critical role of specialized metabolism in fungal ecology is afforded. The...
Resource Type:: Dissertation
Full Text:: determination of tolypocladamide H, from the beetle pathogen, Tolypocladium inflatum. Investigations of the

Boosting Intracellular Delivery of mRNA Therapeutics

Creator:: Patel, Siddharth D.
Abstract:: Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
Resource Type:: Dissertation
Full Text:: the retina showed a rapid onset (within 4 hr) that persisted for 96 h. The gene delivery was cell

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:: Carpenter, Evan L.
Abstract:: Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
Resource Type:: Dissertation

Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

Creator:: Kim, Jeonghwan
Abstract:: Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
Resource Type:: Dissertation
Full Text:: Supplementary Figure A.3. In vitro mRNA transfection assay after LNP solution treatment for 24 h

Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

Creator:: Sabei, Fahad Yahya
Abstract:: Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in Ewing sarcoma treatment that today include a combination of five chemotherapeutic agents, surgery, and/or radiotherapy, these therapies have demonstrated limited improvement...
Resource Type:: Dissertation
Full Text:: observed in T1-weighted MR image 24 h post IV injection of gadolinium (Gd-BOPTA) in the necrotic tumor

Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

Creator:: Cote, Brianna M.
Abstract:: Nearly 80% of solid tumors, such as melanoma, metastasize via the lymphatic system. The most common form of melanoma is BRAF-mutant melanoma, and additional mutations, such as a PTEN mutation in the PI3K pathway, is required for metastases to occur. Standard therapy includes treatment with small molecules dabrafenib (DAB) and...
Resource Type:: Dissertation

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Creator:: Axton, Elizabeth R.
Abstract:: Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
Resource Type:: Dissertation

Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

Creator:: DuRoss, Allison N.
Abstract:: The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
Resource Type:: Dissertation
Full Text:: . ..................................................... 108 Figure 2.7: In vivo evaluation of therapeutic efficacy by H&E, CC3, and 𝛾H2AX tissue staining

Safety of Phytoestrogenic Botanical Dietary Supplements: in vivo and in vitro Evaluation of Botanical-Drug Interactions

Creator:: Chen, Luying
Abstract:: Popular botanical dietary supplements marketed for management of menopausal symptoms, including hops (Humulus lupulus L.), red clover (Trifolium pratense) and licorice (Glycyrrhiza uralensis), were evaluated for their potential to alter CYP-mediated drug metabolism clinically and pre-clinically. Both hops and red clover had been reported to inhibit certain cytochrome P450 (CYP)...
Resource Type:: Dissertation

ScholarsArchive@OSU

Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

Drug Discovery and Chemical Ecology Investigations of Specialized Metabolism in Tolypocladium and Paraisaria

Boosting Intracellular Delivery of mRNA Therapeutics

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

Safety of Phytoestrogenic Botanical Dietary Supplements: in vivo and in vitro Evaluation of Botanical-Drug Interactions

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