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Filtering by: Creator LaDu, Jane Remove constraint Creator: LaDu, Jane Degree Field Pharmaceutical Sciences Remove constraint Degree Field: Pharmaceutical Sciences

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  • Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

    Creator:
    Osborn, Andrew
    Abstract:
    Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
    Resource Type:
    Dissertation
    Full Text:
    EEVS. Dr. Kelsey Kean modeled the EEVS active site. Jane LaDu assisted with the acquisition and

  • Regulation of Secondary Metabolite Production in Streptomyces

    Creator:
    Abdullah, Alanzi R.
    Abstract:
    Among the myriad of natural products are pseudosugar-containing secondary metabolites, e.g., the C7-pseudosugar-containing oligosaccharide acarbose, the C6- pseudosugar-containing aminoglycoside antibiotics, and the five-membered ring pseudosugar-containing antibiotic pactamycin. The C7-pseudosugars are normally derived from sedoheptulose 7-phosphate catalyzed by a family of enzymes called sedoheptulose 7-phosphate cyclases (SH7PCs). This family of enzymes...
    Resource Type:
    Dissertation
    Full Text:
    , Dr. Benjamin Philmus, Dr. Jane Ishmael and Dr. Qinglai Meng. Without their guidance, I would have

  • Development of Novel Agents to Combat Tuberculosis and Malaria

    Creator:
    Almabruk, Khaled Husain G.
    Abstract:
    Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...
    Resource Type:
    Dissertation
    Full Text:
    double knockout mutant ptmT/H, and Drs. Yuexin Li and Jane X. Kelly did the anti-malarial assay. Khaled