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Filtering by: Creator Reid, J. Leighton Remove constraint Creator: Reid, J. Leighton Degree Field Pharmaceutical Sciences Remove constraint Degree Field: Pharmaceutical Sciences

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Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Creator:

Axton, Elizabeth R.

Abstract:

Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...

Resource Type:

Dissertation
Identification of Cervical Cancer Key Regulators using Network Biology Approach

Creator:

Vyshenska, Dariia

Abstract:

Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of the disease. Currently available treatment methods are limited and emphasize the need for discovery of new therapies that improve patient outcome. Chromosomal amplifications have been identified as a source of...

Resource Type:

Dissertation
Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

Creator:

Osborn, Andrew

Abstract:

Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...

Resource Type:

Dissertation
Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

Creator:

Kim, Jeonghwan

Abstract:

Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...

Resource Type:

Dissertation

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Academic Affiliation

College of Pharmacy3
Environmental and Molecular Toxicology1

Advisor

Mahmud, Taifo1
Morgun, Andrey1
Sahay, Gaurav1
Stevens, Jan F.1

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2018 to 2022

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Committee Member

Alani, Adam1
Bishop, Cecily V.1
Gombart, Adrian1
Indra, Arup1
Ishmael, Jane1
more Committee Members »

Creator

Axton, Elizabeth R.1
Kim, Jeonghwan1
Osborn, Andrew1
Vyshenska, Dariia1

Contributor

Aarnes, Eva Katrine1
Brown, Nicholas S.1
Hioki, Kaito1
Hu, Jialu1
Lam, Khiem C.1
more Contributors »

Date

Date range begin – Date range end

Current results range from 2017 to 2021

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Decade

2020-20291
2010-20193

Degree Field

Pharmaceutical Sciences[remove]4
Toxicology1

Degree Level

Doctoral4

Degree Name

Doctor of Philosophy (Ph.D.)4

Language

English [eng]4

License

All rights reserved4

Non-Academic Affiliation

Oregon State University. Graduate School1

Peer Reviewed

No4

Resource Type

Dissertation4

Rights Statement

In Copyright4

Subject

Cervix uteri -- Cancer1
Gene therapy1
Messenger RNA1

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