Cardiac A₁ adenosine receptors mediate cardioinhibitory
properties of adenosine and structural congeners. The objective of
these studies was to increase our understanding of molecular
processes involved in ligand interactions with receptors mediating
cardioinhibitory effects of adenosine and the interactions of these
receptors with guanine nucleotide binding regulatory proteins.
Porcine atrial...
Although considerable experimental evidence suggests that
endogenous adenosine may function as a modulator of neuronal activity
in the etiology or control of seizures, the neuroanatomical and
neurochemical basis for the anticonvulsant actions of adenosine have
not been well established. A discrete brain region of possible
fundamental importance to epileptogenisis within...
Adenosine is considered to be a neuromodulator or
cotransmitter in the periphery and CNS. This neuromodulatory
action of adenosine may be observed as an anticonvulsant effect.
Dose-response curves for R-phenylisopropyladenosine (PIA),
cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine
(NECA) and S-PIA were generated against
PTZ seizure thresholds in the rat. The rank...