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New bioactive natural products from marine algae and cyanobacteria

Creator:: Sabry, Omar Mohamed
Abstract:: This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
Resource Type:: Dissertation
Full Text:: channel blocking activity (EC = 0.3 and 0.9 pg/mi, respectively). Stypoaldehyde, as well as the previously

Regulation of inositol phospholipid hydrolysis by extended treatment with angiotensin II in human aortic smooth muscle cells

Creator:: Niibori, Yoshiko
Abstract:: Long-term stimuli of many systems leads to decreased cellular responsiveness, or desensitization. We characterized the desensitization of angiotensin II (Ang 11)-mediated inositol phospholipid (IP) hydrolysis in cultured human aortic smooth muscle cells (HASMC). Although it has been suggested that the desensitization induced by long-term Mg II exposure may result partially...
Resource Type:: Masters Thesis

Development of Hot-melt Pan-coating, Application to Sustained-release Capsules and Tamper Resistant-coating. 2) Formulation of Verapamil HCl and Diltiazem HCl Semisolid Matrix Capsules. 3) Novel Sustained Release Tablet of Glipizide: Compression of Coated Drug Beads, Formulation, Dissolution, and Convolution. 4) Verapamil Sustained Release: New Formulation and Convolution

Creator:: Nguyen, Chien Ngoc
Abstract:: Hot-melt pan-coating, which is a novel coating method and takes 2-3 hours for 300 mg coating weight gain per capsule and tamper-resistant coating, which takes 30 minutes, is much faster than tedious sugar coating and allows greater coating weight gains in shorter times than spray-melt coating. Although hot-melt pan coating...
Resource Type:: Dissertation

Deciphering the molecular mechanisms of the transcriptional regulation mediated by orphan nuclear receptor COUP-TFI and C2H2 zinc finger protein Ctip2

Creator:: Zhang, Lingjuan
Abstract:: COUP-TFI, an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily, plays important roles in homeostasis and the CNS development, including differentiation, patterning, axonal projection, cell migration, cortical arealization and the temporal specification of neural stem cells. A number of COUP-interacting proteins have been described previously, and the majority of...
Resource Type:: Dissertation

Synthesis and evaluation of affinity labels based on peptide antagonists for delta opioid receptors

Creator:: Maeda, Dean Yoshimasa
Resource Type:: Dissertation
Full Text:: (EC 3.4.11), and the Gly-Phe bond is susceptible to enzymatic 12 proteolysis by either the

Some pharmacological mechanisms and the interrelationship of bulbocapnine and 5-hydroxytryptamine on the cardiovascular system of the dog

Creator:: Fakouhi, Taghi
Resource Type:: Dissertation
Full Text:: . cardl,ec arrcet Ln dlartolc (19, p.546). Itith a nodcrate Lncrcarc of, about onc to *rc q/Il.ter

Solid phase synthesis of dynorphin analogues as probes of Kappa opioid receptors

Creator:: Story, Sandra Catherine
Resource Type:: Dissertation
Full Text:: inactivates the peptide. Tyri is liberated from dynorphin by aminopeptidase M (EC 3.4.11.2) (Marks et al

Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin, Preparation of orally disintegrating tablets of melatonin and acetaminophen, Pharmacokinetics of terbinafine in penguins

Creator:: Le, Hang Thi
Abstract:: The first project of this thesis is an in vitro study. This study was performed with 8 hydrocortisone topical products on the market for the purpose of comparing one Tec Lab product, a Corticool gel, to the other seven common products on the market. The permeation of these products was...
Resource Type:: Dissertation

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:: Han, Bingnan
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
Resource Type:: Dissertation
Full Text:: is a blocker of voltage-sensitive Na channel in mouse neuro-2a cells (EC = 1 nM). In an inflammatory

The study of pharmacokinetics in a clinical environment

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation

ScholarsArchive@OSU

New bioactive natural products from marine algae and cyanobacteria

Regulation of inositol phospholipid hydrolysis by extended treatment with angiotensin II in human aortic smooth muscle cells

Deciphering the molecular mechanisms of the transcriptional regulation mediated by orphan nuclear receptor COUP-TFI and C2H2 zinc finger protein Ctip2

Synthesis and evaluation of affinity labels based on peptide antagonists for delta opioid receptors

Some pharmacological mechanisms and the interrelationship of bulbocapnine and 5-hydroxytryptamine on the cardiovascular system of the dog

Solid phase synthesis of dynorphin analogues as probes of Kappa opioid receptors

Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin, Preparation of orally disintegrating tablets of melatonin and acetaminophen, Pharmacokinetics of terbinafine in penguins

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

The study of pharmacokinetics in a clinical environment

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