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The progression of aflatoxin B₁ (AFB₁) hepatocarcinogenesis in rainbow trout (Oncorhynchus mykiss) : I. AFB₁ metabolism and cytotoxicity affecting hepatocarcinogenesis II. Ultrastructure of hepatocellular neoplasms

Creator:: Núñez, Oliva
Resource Type:: Masters Thesis
Full Text:: deeply grateful to my good friends Jerri, Susan and Pat, and Lani for their encouragment and friendship

Modulation of chemically-induced hepatocarcinogenesis by indole-3-carbinol : mechanisms and species comparison

Creator:: Oganesian, Aram
Abstract:: There is plenty of evidence from epidemiology studies supporting a link between certain components in the human diet and cancer incidence. It is estimated that 3-4 million annual cases of cancer could be prevented worldwide just by changing dietary habits. In parts of the world where vegetables and fruits constitute...
Resource Type:: Dissertation
Full Text:: (1991). 15. A.T. Fong, J.D. Hendricks, R.H. Dashwood, S. Van Winkle, B.C. Lee, and G.S. Bailey

Developmental and dietary regulation of flavin-containing monooxygenase

Creator:: Su, Shelley A. Larsen
Resource Type:: Dissertation
Full Text:: & Hall,London. pp. 91-105 (1991). 23 66. Lee, M.-Y., Smiley, S., Kadkhodayan, S, Hines, R. N., and

Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Creator:: Stresser, David M.
Resource Type:: Dissertation
Full Text:: . Dashwood, Dr. Jack Kelly, Dr. Min-Young Lee, Gayle Orner and Dr. Naoko Takahashi for their advice

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Creator:: Katchamart, Sirinmas
Abstract:: Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower. I3C has been shown to have anticarcinogenic activity against many chemical carcinogens in multiple target organs in animal models. However, the anticarcinogenic activity of I3C is considered indirect since...
Resource Type:: Dissertation

Characterization of androgenic and estrogenic responses in the rainbow trout by comparing liver slice to whole animal studies

Creator:: Shilling, Adam D.
Resource Type:: Dissertation

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Creator:: Yu, Zhen
Abstract:: Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
Resource Type:: Dissertation
Full Text:: , Mohaiza Dashwood, Barbara McVicar, Dr. Rong Wang, Dr. David Yu, JungA Lee, Dr. John Mata, Dr. Doolalai

Application of toxicogenomics to determine mechanism of tumor modulation by dietary indole phytochemicals in hepatocellular carcinoma

Creator:: Tilton, Susan C.
Abstract:: Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), a primary I3C derivative in vivo, are known chemopreventive agents available as dietary supplements. I3C was found to suppress or enhance tumors in several animal models. Chemoprotection is attributed to the ability of indoles to alter carcinogen metabolism effectively blocking initiation. However, mechanisms for enhancement...
Resource Type:: Dissertation
Full Text:: , a semi-purified casein-based diet (Lee et al., 1991). Administration of 500 or 1500 ppm 13C or DIM

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Creator:: Rohlman, Diana
Abstract:: The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
Resource Type:: Dissertation
Full Text:: frequency of NKp46 (NK1.1 neg NKp46 + ) NK-like cells was diminished (Lee et al. 2012). More recently

ScholarsArchive@OSU

The progression of aflatoxin B₁ (AFB₁) hepatocarcinogenesis in rainbow trout (Oncorhynchus mykiss) : I. AFB₁ metabolism and cytotoxicity affecting hepatocarcinogenesis II. Ultrastructure of hepatocellular neoplasms

Modulation of chemically-induced hepatocarcinogenesis by indole-3-carbinol : mechanisms and species comparison

Developmental and dietary regulation of flavin-containing monooxygenase

Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Characterization of androgenic and estrogenic responses in the rainbow trout by comparing liver slice to whole animal studies

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Application of toxicogenomics to determine mechanism of tumor modulation by dietary indole phytochemicals in hepatocellular carcinoma

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

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