Index Catalog // ScholarsArchive@OSU

Hemoglobin adducts of the organophosphate insecticide azinphos-methyl

Creator:: Bailey, Bonnie J.
Abstract:: Reported here is an investigation to determine if azinphos-methyl (AZM), an organophosphate insecticide, adducts to hemoglobin, and if so, whether the hemoglobin adduct could be used as a quantitative marker of occupational AZM exposure. We hypothesized that AZM, or a metabolite of AZM, binds to hemoglobin in erythrocytes forming an...
Resource Type:: Dissertation
Full Text:: physiological role for that enzyme has been defined, use of the term cholinesterase assumes AChE unless

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Creator:: Katchamart, Sirinmas
Abstract:: Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower. I3C has been shown to have anticarcinogenic activity against many chemical carcinogens in multiple target organs in animal models. However, the anticarcinogenic activity of I3C is considered indirect since...
Resource Type:: Dissertation
Full Text:: supplementation are its estrogenic effect as seen in trout and its ability to induce cytochrome P45 Os involved

Biochemical and molecular characteristics of selenoprotein W

Creator:: Gu, Qiu-Ping
Resource Type:: Dissertation
Full Text:: effect of substantially high selenium levels on human health was found in China, Enshi county of Hubei

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: promotes subcellular distribution of SR-BII to murine hepatic microsomes while having no effect on liver

Molecular and cellular mechanisms of aromatic hydrocarbon axonopathy

Creator:: Kim, Min-Sun
Abstract:: Hydrocarbon solvents are widely used in the production of paints, adhesives, dyes, polymers, plastics, textiles, printing inks, agricultural products and pharmaceuticals. While the neuropathic potential of aliphatic solvents was shown in the 1970s, little is known about the neuropathic potential of aromatic solvents. The present study examines such solvents, 1,2-diethylbenzene...
Resource Type:: Dissertation
Full Text:: 3.1 In-vitro effect of diacetylbenzene isomers on test proteins bovine serum albumin and ribonuclease

Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Creator:: Stresser, David M.
Resource Type:: Dissertation
Full Text:: Effect of dietary I3C and BNF, alone or in combination, on the in vitro hepatic microsome-mediated

Selenoprotein W : distribution and function in rat tissue and cultured cells

Creator:: Sun, Yu, 1963-
Abstract:: The objective of this study was to further determine the distribution of selenoprotein W (SeW) in tissues from rats and sheep fed different selenium levels and to search for the possible functions of this protein. In the rat study a total of 28 rat tissues were examined and SeW was...
Resource Type:: Dissertation
Full Text:: SELENOPROTEINS 7 MAMMALIAN SELENOPROTEINS 14 CHAPTER 2 EFFECT OF DIETARY SELENIUM ON SELENOPROTEIN W AND

Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Creator:: Ruby, Carl E.
Abstract:: In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...
Resource Type:: Dissertation
Full Text:: .................................................................................. Tab'e of Contents (Continued) Page Chapter 4: Effect of 2,3,7,8 Tetrachlorodibenzo-p-Dioxin on Nitric

Chronic exposure of rodents to indole-3-carbinol and 3,3'-diindolylmethane : implications for drug metabolism, chemoprevention and human health

Creator:: Leibelt, Dustin A.
Abstract:: Indole-3-carbinol (I3C) is a naturally occurring plant alkaloid, found in significant concentrations in cruciferous vegetables such as broccoli and Brussels sprouts. I3C is an unstable compound that undergoes rapid oligomerization in an acidic environment to form higher order condensation products (I3C-ACPs), such as 3-3'-diindolylmethane (DIM). Both I3C and DIM are...
Resource Type:: Dissertation
Full Text:: DIM exposures in rodent models to further elucidate the effect these compounds might have on health

Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

Creator:: Wang, Qi
Abstract:: Mitotic recombination is a common autosomal mutation in mammalian cells involving crossover events between homologous chromosomes. This process can convert a cell with a heterozygous deficiency to one with a homozygous deficiency, and thus often represents the second step in tumor suppressor gene inactivation. In this study I examined the...
Resource Type:: Masters Thesis
Full Text:: ........................................................ . Effect of Mlhl status on cell survival to ionizing radiation ........................ . Mutagenic

ScholarsArchive@OSU

Hemoglobin adducts of the organophosphate insecticide azinphos-methyl

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Biochemical and molecular characteristics of selenoprotein W

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Molecular and cellular mechanisms of aromatic hydrocarbon axonopathy

Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Selenoprotein W : distribution and function in rat tissue and cultured cells

Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Chronic exposure of rodents to indole-3-carbinol and 3,3'-diindolylmethane : implications for drug metabolism, chemoprevention and human health

Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

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