Index Catalog // ScholarsArchive@OSU

Dissecting DNA Damage Responses in Arabidopsis: A High-Throughput Sequencing Approach

Creator:: Brar, Anantnoor K., Wilcox, Buck W. L., Curtis, Marc, and Hays, John B.
Abstract:: Cells are constantly bombarded with mutagens, both endogenous and exogenous in origin. Endogenous sources of mutation include reactive oxygen species formed during aerobic respiration, replication errors by DNA polymerase, and spontaneous deamination and depurination (Jackson 2009). Exogenous sources of mutation include UV and ionizing radiation, aflatoxins, and polycyclic aromatic hydrocarbons...
Resource Type:: Honors College Thesis
Full Text:: , Marc Curtis3, and John B. Hays2, 4 1Department of Biochemistry and Biophysics, 2Environmental and

Dissecting DNA Damage Responses in Arabidopsis: A High-Throughput Sequencing Approach

Creator:: Brar, Anantnoor
Abstract:: A unique, permanent root-growth arrest phenotype was observed in UV-B irradiated Arabidopsis thaliana roots lacking the DNA damage response kinase ATR. Segregation analysis suggests the dependence of this phenotype on another, unidentified gene, termed ursu. High-throughput sequencing technologies were used to map and identify the causal ursu mutation. Illumina HiSeq...
Resource Type:: Honors College Thesis
Full Text:: : ____________________________________________________ John B. Hays A unique, permanent root-growth arrest phenotype was observed in UV-B

Repression of DNA Mismatch Repair (MMR) in Arabidopsis thaliana through Dominant-Negative MMR Proteins

Creator:: Mohamed, Aly
Abstract:: The highly conserved multi-protein mismatch repair (MMR) system is known for its ability to correct post replication errors in genomic DNA. A hallmark of MMR deficiency in all organisms is microsatellite instability. The initiating proteins in the eukaryotic MMR system are hetrodimers formed with an integral MSH2 subunit and one...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ John B. Hays The highly conserved multi-protein mismatch repair (MMR) system is known for its

Investigating a Role for DNA Mismatch Repair in Signaling a Benzo[a]pyrene Diol Epoxide-Induced DNA Replication Arrest, Investigating a Role for Mismatch Repair in Activating a Benzo[a]pyrene Diol Epoxide-InducedS-phase Checkpoint

Creator:: Coburn, Jacki L.
Abstract:: Genetic and environmental factors influence individual cancer risk. Mutations in DNA mismatch repair (MMR) genes increase colon cancer risk. Exposure to carcinogens, including the ubiquitous polycyclic aromatic hydrocarbons (PAHs), also is associated with increased cancer risk. To understand the combined effects of both environmental exposures and genetic risk, we investigated...
Resource Type:: Undergraduate Thesis and Presentation

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:: Kernan, Casey P.
Abstract:: DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Resource Type:: Honors College Thesis
Full Text:: mutations, and to the serving committee members, Dr. John Hays and Dr. Katherine Fields. Additional

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:: Kernan, Casey P.
Abstract:: DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Resource Type:: Presentation and Undergraduate Thesis

SEM Analysis of Digestive Wear on Rodent Bones: A comparison of modern and fossil remains

Creator:: Hay-Roe, Samuel
Abstract:: When people think of fossils, they generally imagine the bones of large, charismatic animals. However, small mammals are an ecologically important group of organisms that show up frequently in the fossil record, and can frequently function as indicators for local environmental and ecological conditions (Terry, 2007, 2010). Rodent and rabbit...
Resource Type:: Poster
Full Text:: comparison of modern and fossil remains Samuel Hay-Roe and Rebecca Terry COLLEGE OF SCIENCE DEPARTMENT OF

The use of redwood for home construction

Creator:: Hays, Lewis T.
Resource Type:: Undergraduate Thesis
Full Text:: for Home Construction Lewis T. Hays, r, A Thesis Presented to the Faculty of the School of

Drunken Walking: A Novel Brownian Dynamics Simulation for the Mechanochemical Cycle of the Dynein Motor Protein

Creator:: Waczak, John L.
Abstract:: The dynein molecule is a peculiar motor protein recognized for its unique stepping behavior. Sometimes it steps forwards. Other times it steps backwards. It has even been observed to occasionally shuffle by beginning a step with the same domain many times in row. These motions make dynein an interesting object...
Resource Type:: Undergraduate Thesis
Full Text:: the Mechanochemical Cycle of the Dynein Motor Protein by John Waczak an undergraduate thesis

Un Paseo encantado

Creator:: Joyner, Taylor B.
Abstract:: Un Paseo Encantado, an enchanted walk, is a collection of my observations and experiences in a study abroad program in Oviedo, Spain. My commentary on Spanish culture is based on reading I did prior my departure, in combination with my observations while in Spain. In six chapters, I explore the...
Resource Type:: Honors College Thesis
Full Text:: Taylor B Joyner for the degree of Honors Baccalaureate of Science in Animal Sciences presented on May 31

ScholarsArchive@OSU

Dissecting DNA Damage Responses in Arabidopsis: A High-Throughput Sequencing Approach

Dissecting DNA Damage Responses in Arabidopsis: A High-Throughput Sequencing Approach

Repression of DNA Mismatch Repair (MMR) in Arabidopsis thaliana through Dominant-Negative MMR Proteins

Investigating a Role for DNA Mismatch Repair in Signaling a Benzo[a]pyrene Diol Epoxide-Induced DNA Replication Arrest, Investigating a Role for Mismatch Repair in Activating a Benzo[a]pyrene Diol Epoxide-InducedS-phase Checkpoint

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

SEM Analysis of Digestive Wear on Rodent Bones: A comparison of modern and fossil remains

The use of redwood for home construction

Drunken Walking: A Novel Brownian Dynamics Simulation for the Mechanochemical Cycle of the Dynein Motor Protein

Un Paseo encantado

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