Index Catalog // ScholarsArchive@OSU

Analyzing the use of the acellular DCFH assay as a means of determining oxidative stress induced in zebrafish embryos exposed to lanthanide oxide nanoparticles

Creator:: Engstrom, Arek
Abstract:: The ability of nanoparticles (NPs) to induce oxidative stress on organisms has been linked to NP cytotoxicity and genotoxicity for a variety of organisms. One proposed mechanism of this increased oxidative stress is the ability of NPs to generate reactive oxygen species (ROS). Due to the dynamic nature and small...
Resource Type:: Honors College Thesis
Full Text:: . Toxicology Letters, 174(1–3), 1–9. https://doi.org/10.1016/j.toxlet.2007.08.001 Geitner, N. K., Marinakos

Enhancing Protocols to Improve Consistency Across Nanotoxicology Studies

Creator:: Luker, Sabrina R.
Abstract:: In current nanotoxicology research, there is a lack of standardization in reporting of zebrafish exposure media and sonication practices. This lack of standardization in use and reporting methods has made reproducing nanoparticle (NP) toxicity results between labs a common issue. It is important to have a standardized way of reporting...
Resource Type:: Undergraduate Thesis
Full Text:: : Stacey Harper, Environmental and Molecular Toxicology Date Andrew B. Buermeyer, Environmental

Exposure to the Mycotoxin Zearalenone Impairs Embryonic Development in Zebrafish

Creator:: Sidebotham, Nicole A.
Abstract:: A study was conducted to evaluate the developmental toxicity of three commonly detected mycotoxins in food (deoxynivalenol, patulin, and zearalenone) using the zebrafish (Danio rerio) model. Mycotoxin exposures were carried out at five concentrations (0.0064, 0.064, 0.64, 6.4, and 64 μM). Morphological and photomotor screenings were conducted at 24 hours...
Resource Type:: Honors College Thesis
Full Text:: activity and steroidogenesis in vitro. Toxicology Letters 229 (2), 366-373. Geier, David A., Janet K

Comparative toxicological assessment of PAMAM and thiophosphoryl dendrimers using embryonic zebrafish.

Creator:: Pryor, Joseph Brian
Abstract:: Dendrimers are well-defined, polymeric nanomaterials currently being investigated for their biomedical applications. Initially, higher generation (size) dendrimers were of interest because of their drug carrying capacity. However, increased generation was associated with increased toxicity. The objective of the present study was to investigate the role of surface charge and generation...
Resource Type:: Honors College Thesis
Full Text:: dysfunction. Toxicology Letters. 2009;190(2):202-207. 47. Mukherjee SP, Byrne HJ. Polyamidoamine dendrimer

The 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio in Human Urine as a Biomarker of Cancer Chemoprevention Following Exposure to Brussels Sprouts and the Phytochemical, 3,3’-Diindolylmethane (DIM)

Creator:: Chen, Danny
Abstract:: Estrogen is a sex hormone responsible for the development and regulation of the reproductive system and secondary sex characteristics. They also play a critical role in the development of breast and uterine cancer. The formation of agonistic metabolites of estrogen, especially 16α-hydroxyestrone, have been found to have cancer-inducing effects meanwhile...
Resource Type:: Honors College Thesis
Full Text:: : _____________________________________________________________________ David E. Williams, Mentor, representing Environmental and Molecular Toxicology/Linus Pauling

Songbird feathers as indicators of mercury exposure : Patterns across feather tracts and correlations to other tissues

Creator:: Low, Katherine E.
Abstract:: Monitoring mercury (Hg) exposure in avian populations is critical to understanding the effects of this neurotoxin. Avian Hg exposure is commonly evaluated by measuring Hg concentrations in internal tissues, blood, and feathers. Feathers are a popular sampling matrix due to ease of sampling and limited stress to birds. However, it...
Resource Type:: Honors College Thesis
Full Text:: . Error bars represent 95% confidence intervals; different letters indicate statistically significant

Utilization of structure-activity-relationship for predicting chemical toxicity in primary human lung cells

Creator:: Galbreath, Amanda
Abstract:: There is a growing need to establish alternative approaches for assessing hazard from chemical exposure compared to the traditional method of animal testing. Approaches that relate chemical structure to biological activity are gaining acceptance in the field as in silico methods for characterizing and predicting chemical toxicity. In this study,...
Resource Type:: Undergraduate Thesis
Full Text:: Baccalaureate of Science, BioResource Research, Toxicology Option 05/26/2023 Amanda Galbreath

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: Science in BioResource Research, Toxicology and Biotechnology (Honors Scholar) Presented

Effects of Xanthohumol on Biomarkers of Metabolic Syndrome in Obese Rats

Creator:: Moreno Luna, Arlyn Y.
Abstract:: Flavonoids are a large family of compounds synthesized by plants that have a common chemical structure. It is believed that the health effects of fruits and vegetables are primarily due to dietary flavonoids content. Current research indicates that dietary flavonoids show promise for mitigating and/or preventing chronic conditions associated with...
Resource Type:: Honors College Thesis
Full Text:: . / Cancer Letters 246 (2007) 201–209202 6 1.4.1 Health benefits: In Germany, hop baths were

Comparison of Veterinary Curriculum between Veterinary Schools in the United States, English Speaking Countries (non-United States), and Non-English Speaking Countries

Creator:: Forsyth, Kiersten K.
Abstract:: Veterinary medicine impacts everyone in the world to some degree and veterinary medicine is taught in some format in every country across the globe. However, veterinary education differs between countries due to the environmental and cultural variations. The purpose of this study was to investigate how veterinarians are trained in...
Resource Type:: Honors College Thesis
Full Text:: ECVPH European College of Veterinary Pharmacology and Toxicology ECVPT European College of Veterinary

ScholarsArchive@OSU

Analyzing the use of the acellular DCFH assay as a means of determining oxidative stress induced in zebrafish embryos exposed to lanthanide oxide nanoparticles

Enhancing Protocols to Improve Consistency Across Nanotoxicology Studies

Exposure to the Mycotoxin Zearalenone Impairs Embryonic Development in Zebrafish

Comparative toxicological assessment of PAMAM and thiophosphoryl dendrimers using embryonic zebrafish.

The 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio in Human Urine as a Biomarker of Cancer Chemoprevention Following Exposure to Brussels Sprouts and the Phytochemical, 3,3’-Diindolylmethane (DIM)

Songbird feathers as indicators of mercury exposure : Patterns across feather tracts and correlations to other tissues

Utilization of structure-activity-relationship for predicting chemical toxicity in primary human lung cells

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Effects of Xanthohumol on Biomarkers of Metabolic Syndrome in Obese Rats

Comparison of Veterinary Curriculum between Veterinary Schools in the United States, English Speaking Countries (non-United States), and Non-English Speaking Countries

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