Deep foundations are necessary for the construction of many structures, such as bridges and buildings, located in areas unsuitable for shallow foundations. Owing to the inherent variability of soil and the complex changes that occur in the soil adjacent to deep foundations as they are installed, the ability to accurately...
The intracellular life cycle of Chlamydia has been difficult to study due to the inability to genetically manipulate the bacteria. As a result, indirect methods have been employed to study the pathogen and the aspects that contribute to its unique intracellular life cycle. A wide variety of laboratory adapted strains,...
Chlamydia is an obligate intracellular bacterial pathogen that causes a variety of disease in animals and humans worldwide. Veterinary chlamydial pathogens can lead to chronic infections and serious consequences that result in millions of dollars of losses in animals and resources in the agricultural industry in countries that rear ruminants....
The chlamydiae are a family of obligate intracellular bacteria that have a unique bi-phasic developmental cycle, unique cellular properties, and a unique set of challenges to studying its biology. While genetic manipulation is becoming routine in Chlamydia, there are significant challenges to working with this intracellular parasite. The body of...
RNA-Sequencing (RNA-Seq) has rapidly become the de facto technique in transcriptome studies. However, established statistical methods for analyzing experimental and observational microarray studies need to be revised or completely re-invented to accommodate RNA-Seq data's unique characteristics. In this dissertation, we focus on statistical analyses performed at two particular stages in...
The majority of low-rise residential structures in the U.S. are constructed with wood. Wood-based composites are primary building materials in these structures, used as structural sheathing, joists, and beam components. Wood composites are susceptible to degradation upon exposure to high levels of moisture. Moisture durability is routinely assessed with accelerated...
Numerous diseases and injuries can limit a person's ability to perform everyday tasks -- things like getting dressed, bathing, and eating. Anything that requires physical activity can be affected; even simple things like turning on the lights can become difficult or impossible. Until recently, the only way for a person...
Fuel qualification timelines for new fuel technology under ideal conditions can take between 20-25 years to be fully qualified from initial concept to deployment as full fuel assemblies. To reduce the timeline and costs, new separate-effects test and integral-effects test experiments, advanced instrumentation, and advanced modeling and simulation tools are...
Five U.S. high performance research reactors (HPRRs) are currently part of an international nonproliferation program with the objective of ultimately converting their highly enriched uranium (HEU) fuel to a new high density, low enriched uranium (LEU) fuel while still maintaining their reactor kinetic and thermal hydraulic performance. A uranium-molybdenum (U-Mo)...
The purpose of this dissertation study was to increase understanding of licensed mental health professionals' experiences as they have encountered and navigated through compassion fatigue (CF). CF is a complex construct with an attendant constellation of secondary stress responses. In order to examine the complex and varying factors associated with...