In this thesis, I present studies in the field of terahertz (THz) spectroscopy. These studies are divided into three areas: Development of a narrowband THz source, the study of carrier transport in metal thin films, and the exploration of coherent dynamics of quasi-particles in semiconductor nanostructures with both broadband and...
Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
The central purposes of this study were to review the
historical sources of David Kolb's formulation of experiential
learning theory, and to determine the effect and
application of Kolb's theory and Learning Style Inventory
as reflected in the literature between 1971 and 1990.
It was found that Kolb based his...
High Temperature Gas Reactors (HTGRs) are positioned to disrupt local and global markets via their unique ability to produce carbon-free process heat, high efficiency power generation, and passively safe operational features. However, significant impediments still exist to delay deployment of this particular technology, including a lack of experimental data, verified...
The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
Optimization of reservoir operation is involves various competing objectives for a scarce resource (water). To find the optimal operation of reservoirs, it is essential to consider multiple objectives simultaneously. There are various sources of uncertainty associated with the reservoir operation problem that should be considered as well.
The overarching goal...
Influenza A and Respiratory Syncytial Virus (RSV) are both enveloped, negative strand
RNA viruses which infect the respiratory mucosa of animals and humans. Despite
decades of research and development of antivirals and vaccines, both of these viruses
continue to be a major health concern throughout the world. The focus of...
Studies toward the total syntheses of highly potent cytotoxic alkaloids
including the bromopyrrole alkaloids and indole alkaloids were conducted and are
described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
The solution structure determination of DNA molecules has been an important part of structural biology. NMR solution structures are a complement to structures solved via X-ray crystallography; the two methods are the only ways of obtaining three dimensional coordinates of macromolecules. Because of the nature of the molecule, the solution...