Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
The complexity of forest management has increased with the scope of resources of concern and the level of scrutiny from stakeholders. The design and use of specialized computer software, often referred to as “decision support systems” (DSS), is one method for helping managers deal with this complexity. DSS have proven...
Shear wave attenuation measurements were made
using ceramic bimorph transducers to excite transverse
vibrations in a cylindrical column of unconsolidated
sediment. Three different water-saturated
sediments were used in an attempt to determine the
effects of grain shape and sorting on the frequency
dependence of attenuation. The mean grain size of...
The heritability of resistance to eastern filbert blight, caused by Anisogramma anomala, in European hazelnut (Corylus avellana) was evaluated in the progeny of seven cultivars crossed in 12 combinations. Progeny produced by crossing 'VR6-28' with three susceptible cultivars segregated 1:1 for complete resistance to eastern filbert blight. Histograms of disease...
This research dealt with the direct environmental influence of atmospheric vapor pressure on stomates of Pseudotsuga menziesii, Picea engelniannii, and Fragaria X ananassa, and the indirect physiological
control of stomates by abscisic acid in Pseudotsuga menziesii. Two ventilated porometers (diffusion and steady-state) were compared on four broadleaf and five coniferous...
This dissertation investigates the effect of endogenous and exogenous events on firm behavior and performance. These are fundamental questions in economics. The contribution of this study is threefold. First, it provides estimates of the impact of mergers on railroad efficiency, which has important antitrust implications. Second, it provides new estimates...
Forests are highly valuable resources providing both timber as well as many non-use values like habitat for various endangered and threatened species, carbon sequestration, and recreation, to name a few. Given that there are 765 million acres of forestland in the United States, almost 60% of which are privately owned,...
The focus of this dissertation was to understand protein function and structure ona molecular level. To do this successfully, a variety of biochemical and biophysicaltechniques were employed. A wide variety of techniques were applied to study theproteins of interest in this dissertation to probe protein-protein interactions, proteinfunction, protein structure, and...
The application of modern land management practices beginning at the turn of the 20th century is widely believed to have dramatically transformed forest landscapes of the inland Pacific Northwest. Restoring historical conditions to make forests resilient to future climate and disturbance regimes is a major goal of federal forest managers....