Male Sprague Dawley rats received a single intraperitoneal dose
of BCNU in experiments designed to measure biochemical changes associated with the pulmonary toxicity described for this agent. Changes in
serum and lung lavage angiotensin converting enzyme (ACE) activity
were measured to detect changes in pulmonary endothelial cell integrity. Alpha-1-proteinase inhibitor...
There has been no toxicologic proof that the long-term, low-level
exposure of man to chlorophenothane (DDT) is linked with an
increased susceptibility to toxicity or disease. Acute pretreatment
of rats with 75-100 mg/kg DDT has been demonstrated to potentiate
CCI₄-induced hepatotoxicity in that species (McLean and McLean,
1966). Since the...
Research Objective: Nearly 60 million people in the United States reside in a rural area. Residents in rural areas have higher rates of chronic disease, risky health behaviors, disability, infant mortality, and age-adjusted mortality than their urban counterparts. Health insurance and access to care mitigate those risks, in part because...
Public Law 94-142, passed in 1975, mandated that all children receive a free and
appropriate education regardless of the extent of their handicapping condition. Handicapped
students were to be educated in the "least restrictive environment" possible. Placing handicapped
students in regular classrooms has been termed "mainstreaming." Mainstreaming has produced
concerns...
Stagnation point heat transfer in a gas undergoing relaxation of its
internal energy is examined by solution of the equations of motion
using the two temperature approach of Wang Chang and Uhlenbeck.
The results are presented in parametric form and show that relaxation effects produce an adiabatic wall temperature above...
Preliminary toxicity studies of BCNU in rats revealed that significant
prolongations of pentobarbital hypnosis were associated with
all doses employed. Investigations were undertaken to determine the
underlying mechanism responsible for this observed effect. Studies
on the in vitro metabolism of pentobarbital by hepatic microsomes
of BCNU-treated animals demonstrated that significant...
Previous investigation showed that 20 mg/kg BCNU
caused inhibition of sulfobromophthalein (BSP) excretion
and inhibited bile salt independent bile flow (BSIF) in
rats by 48 h after treatment (Hoyt, 1984).
The present investigation demonstrated that BCNU
inhibited the canalicular step in the excretion of BSP.
This was indicated by the...
The entire human population is chronically exposed to various
contaminants, including lead and chlorinated hydrocarbon pesticides.
Studies were undertaken to assess the effects of chronic exposure to
lead on the toxicities of two such pesticides, lindane and dieldrin.
Mice were given lead as the acetate in drinking water, at levels...