Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis
in mice and rats. To increase understanding of how chlordecone (CD), an OC
insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD
pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...
Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Thermochemical water splitting cycles have been conceptualized and researched for over half a century, yet to this day none are commercially viable. The heavily studied Sulfur-Iodine cycle has been stalled in the early development stage due to a difficult HI-H₂O separation step and material compatibility issues. In an effort to...
Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
This study investigated complete reductive dechlorination of chlorinated aliphatic hydrocarbons (CAHs) over a broad range of concentrations. Tetrabutoxysilane (TBOS), as a slow-release anaerobic substrate, was studied for enhanced reductive dechlorination of tetrachioroethylene (PCE) present as a dense non-aqueous liquid (DNAPL). Four different site-mixed cultures were used in the study: Site-300...
Indole-3-carbinol (I3C) is a naturally occurring plant alkaloid, found in significant concentrations in cruciferous vegetables such as broccoli and Brussels sprouts. I3C is an unstable compound that undergoes rapid oligomerization in an acidic environment to form higher order condensation products (I3C-ACPs), such as 3-3'-diindolylmethane (DIM). Both I3C and DIM are...
The production of hydrogen has been one of the most heavily studied, energy related fields over the past half century, yet few methods are commercially or economically viable and none are currently sustainable. Of those aiming at the sustainable production of hydrogen using renewable resources, perhaps the most widely studied...
During the past 30 years, numerous studies have focused on the toxicities of polycyclic aromatic hydrocarbons (PAH). Laboratory and field studies have helped elucidate the detrimental effects of these chemicals on growth, reproduction and immune response. Polycyclic aromatic hydrocarbons are in the priority list of chemicals to be studied by...
The seasonal distribution of bioavailable organochiorine contaminants in surface
water and the potential environmental factors influencing their bioavailability were
evaluated. The study was carried at the lower Willamette River at Portland Harbor, Oregon
where surface water runoff varied according to season. Bioavailable water concentrations of
DDTs and PCBs were determined...
The pyrrolizidine alkaloids (PAs) and ergot alkaloids are known natural toxicants found in livestock forage. These alkaloids contribute to large economic losses in livestock throughout the world. An understanding of the mechanisms of toxicity and development of better diagnostic tools for better management practices was investigated. Variability exists in the...