Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'.
The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
A programming paradigm can be defined as a model or an approach employed in solving a problem. The results of the research described in this document demonstrate that it is possible to unite several different programming paradigms into a single linguistic framework. The imperative, procedural, applicative, lambda-free, relational, logic and...
The concentration of ascorbic acid in the plasma was determined on
four levels of ascorbic acid intake for seven day periods in 1946-47 and
on three levels of ascorbic acid intake for ten day periods in 1947-48.
The subjects, eight girls and eight boys, were 16 to 19 year old...
Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled
signaling pathways. Prior research suggested that some isoforms of PLC-β may exist
and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation
assays of differentially-tagged PLC-β constructs and sizeexclusion
chromatography of native PLC-β support homodimerization...
Phospholipase C-Jβ (PLCβ) is an important effector enzyme in G-protein-coupled
signaling pathways. Activation of PLCβ by Gα and Gβy subunits has been fairly well
characterized, but little is known about other protein interactions that may also
regulate PLCβ function. A yeast two-hybrid screen of a mouse brain cDNA library
with...
The purpose of this study of the life and career of Dr. Carl
Leonard Anderson was to recount his professional contributions to
the field of health and relate these to public health and health education. The major emphasis of this study concerned Dr. Anderson's
professional life.
The accomplishment of the...
This dissertation is separated into two parts according to the two major distinct research projects. In Part I, the full account of synthetic studies toward C10-functionalized lycopodium alkaloids is described. In Part II, the detailed discussion on the exploration of the Pummerer cyclization methodology and its application to the total...
A three-part study was conducted into the impact of physiological and ecological variables on the net isotopic fractionation of hydrogen, α[subscript K₃₇], expressed in C₃₇ alkenones. First, alkenone-producer production, abundance, and export were characterized in the summertime Gulf of California and Eastern Tropical North Pacific using compound-specific, labeled in situ...
Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....