Search Constraints

Start Over
Filtering by: Committee Member Blakemore, Paul R. Remove constraint Committee Member: Blakemore, Paul R. Degree Level Master's Remove constraint Degree Level: Master's

Search Results

  • Bioprospecting the Chemical Diversity of Plant-associated Fungi

    Creator:
    González-Montiel, Gisela Abigail
    Abstract:
    Fungi have long been used for discovery of new chemical scaffolds. In the clinical setting, the fungal natural products penicillin, statins, and cyclosporine have revolutionized medicine to treat diseases and infections. In the environment, fungal natural products have been used as herbicides, fungicides, and insecticides to protect crops, livestock, and...
    Resource Type:
    Masters Thesis

  • Synthetic studies toward the total synthesis of azaspiracid-1

    Creator:
    Su, Dong
    Abstract:
    Azaspiracid-1, a novel marine toxin that contains 9 rings and 20 stereogenic centers, has drawn considerable attention from synthetic groups worldwide due to its structural complexity, which includes a unique trioxabisspiroketal fused to a tetrahydrofuran ring (ABCD rings), a piperidine-tetrahydrofuran spiroaminal system fused to a 2,9-dioxabicyclo[3.3.1]nonane system (FGHI rings), a...
    Resource Type:
    Masters Thesis

  • Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

    Creator:
    Snyder, Kevin M.
    Abstract:
    In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...
    Resource Type:
    Masters Thesis
    Full Text:
    Synthesis Abstract approved: ______________________________________________________ Paul Ha

  • Progress Towards the Total Synthesis of Bazzanin K

    Creator:
    Salvo, Patrick
    Abstract:
    Molecular chirality plays a critical role in chemistry, biology, and medicine. To study and better understand conformational chirality, it is necessary to obtain structurally interesting molecules that exhibit this form of chirality. Our lab utilizes total synthesis and methodological development to obtain conformationally chiral natural products of interest. We believe...
    Resource Type:
    Masters Thesis
    Full Text:
    . 5 B. S. Moore, J. L. Chen, G. M. L. Patterson, R. E. Moore, L. S. Brinen, Y. Kato, and J. Clardy, J

  • Terahertz transmission & spectroscopy of vertically grown multi-walled carbon nanotube forests

    Creator:
    Maizy, Louis
    Abstract:
    In this thesis, I present studies in the field of terahertz [THz] spectroscopy. It covers both the generation and detection of ultra-fast broadband THz pulses, as well as the transmission properties of vertically grown multi-walled carbon nanotube forests [MWCNTs]. We have found that these vertically grown MWCNTs respond strongly to...
    Resource Type:
    Masters Thesis
    Full Text:
    . Finally, to my prede- cessors Andy Jameson, Joe Tomaino, and Michael Paul, for sharing their knowledge

  • Improvements in synthesis and response techniques of ion-selective sensors

    Creator:
    Pylypiuk, Nataliia
    Abstract:
    Two improvements to the established procedures for synthesis and response detection of ion-selective optical sensors (optodes) were introduced. The first improvement addresses the drawback of organic dye (optode-localized chromoionophore) photobleaching. This positively impacts fluorescence response and allows for (1) direct measurement of hydrogen ion activity upon binding with the dye,...
    Resource Type:
    Masters Thesis
    Full Text:
    commitment of my graduate committee members: Kim Anderson, Paul Blakemore and Christopher Beaudry

  • Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis

    Creator:
    Carlson, Erik
    Abstract:
    Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...
    Resource Type:
    Masters Thesis
    Full Text:
    extend my appreciation to my committee members, Prof. Paul R. Blakemore, Prof. Kevin P. Gable, Prof

  • Insights into Cytostatic and Cytotoxic Properties of the Natural Product Mensacarcin

    Creator:
    Kaweesa, Elizabeth Namagoba
    Abstract:
    Mensacarcin is a stereogenic complex polyketide with potent anti-tumor activity produced by a soil-dwelling Streptomyces bottropensis. The US National Cancer Institute (NCI) 60 human tumor cell line anticancer drug screen (NCI-60) reveals mensacarcin’s cytostatic properties in almost all tested cell lines and distinct cytotoxic properties specifically in eight melanoma cell...
    Resource Type:
    Masters Thesis
    Full Text:
    support and guidance throughout my studies. I would like to thank my committee members: Dr. Paul

  • Motivating programmers through karma systems

    Creator:
    Cedeno, Jose
    Abstract:
    Keeping FOSS developers motivated is a challenging problem, and their motivation levels can affect the team's productivity and satisfaction, leading to higher or lower productivity. Using reputation systems as a motivator has become the de-facto standard for many online communities, rewarding user's activity through badges of honor or achievement levels....
    Resource Type:
    Masters Thesis
    Full Text:
     am  thankful  to  the  rest  of  my   committee:  Paul  Paulson,  Timothy

  • Process Information Modeling for Characterizing Sustainability Performance of Cyclic Manufacturing Processes

    Creator:
    Manoharan, Sriram
    Abstract:
    Sustainability has become an unprecedented priority in global manufacturing due to the growing concerns over issues such as an aging workforce, environmental degradation, and public health. The simultaneous consideration of the economic, environmental, and social aspects – often referred to as the “three pillars of sustainability” – is crucial to...
    Resource Type:
    Masters Thesis
    Full Text:
    : ___________________________________________________________________ Karl R. Haapala Sustainability has become an unprecedented priority in global manufacturing