Index Catalog // ScholarsArchive@OSU

Phytochemical characterization of Fagonia indica and its effects on MCF-7 breast cancer cell line

Creator:: Kumbi, Yadano
Abstract:: Phytochemicals from the genus, Fagonia, have been attracting increasing attention due to their potential beneficial effects on human health, particularly, anti-cancer properties. Certain Fagonia species contain various types of phytochemicals such as saponins, alkaloids, cardiac glycosides, flavonoids, terpenoids, and tannins. In this study, we investigated the phytochemical composition of a...
Resource Type:: Undergraduate Thesis
Full Text:: . indica without acid hydrolysis was ineffective in inhibiting the growth of human breast cancer cell

Characterizing the symbiotic interactions between Rhodococcus and plants

Creator:: Stevens, Danielle M.
Abstract:: Bacteria are critical to the health of eukaryotes and the ecosystems in which they persist. Some symbiotic interactions are mutualistic in which both microbe and host benefit from the partnership. Other interactions are parasitic, and the microbe typically benefits at a cost to the host. Rhodococcus is a genus of...
Resource Type:: Undergraduate Thesis
Full Text:: Rhodococcus genus and other closely related taxa, the bacteria have an extracellular mycolic acid lipid wall

Impacts of Tertiary Ligands in Catalysis in Thermostable Human Carbonic Anhydrase II by Site-directed Mutagenesis and Genetic Code Expansion

Creator:: Stevens, Danielle M.
Abstract:: Carbonic anhydrases are ubiquitous enzymes that catalyze the reverse hydration and dehydration of carbon dioxide and bicarbonate respectively. A variety of tumors in humans show overexpression of human carbonic anhydrase II (HCA II) leading to an acidic breakdown of carbon dioxide into bicarbonate. While a variety of drug inhibitors exist,...
Resource Type:: Research Paper
Full Text:: inhibitors exist, many come with undesirable side effects. Using non-conical amino acids (ncAAs), we probe

Computational study of the electrostatic interaction between kinesin-5/BimC and the microtubule

Creator:: Chen, Zishi
Resource Type:: Undergraduate Thesis
Full Text:: Bank, Nucleic Acids Res. 28, 235–242 (2000), Doi: 10.1093/nar/28.1.235. [23] J. Yang, R. Yan, A. Roy

Identifying microRNAs by automated phylogenetic and structural analysis

Creator:: Smith, Daniel P.
Abstract:: Motivation: It can take considerable amounts of time and effort to use existing computational tools to analyze a small RNA sequence for the purpose of determining if it is characteristic of microRNA. It is similarly tedious to search for homologs to known microRNA sequences in the rapidly growing collection of...
Resource Type:: Undergraduate Thesis
Full Text:: . Nucleic Acids Res 2. Edgar, Robert C. (2004). MUSCLE: multiple sequence alignment with high accuracy

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Creator:: Mans, Michael-Andres D.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants ubiquitous in the environment and result from the incomplete combustion of fossil fuels. Many PAHs have been identified as procarcinogenic, and are metabolized to form DNA adducts; however, other mechanisms also may contribute to toxicity and help explain differences in toxicity...
Resource Type:: Undergraduate Thesis
Full Text:: - Volume plate and pre-programmed Gen5 protocols for nucleic acid detection. Isolated RNA was submitted

Toxicity Screening of Polycyclic Aromatic Hydrocarbons (PAHs) in Primary Human Bronchial Epithelial Cells

Creator:: Amador, Samantha B.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a known class of chemicals that are linked to a multitude of adverse health outcomes. There are over 1,500 of these chemicals across various families and subgroups. 16 of these PAHs, known as parent PAHs, are identified by the EPA for focused risk assessment within...
Resource Type:: Undergraduate Thesis
Full Text:: direct injury to protein, lipids, and nucleic acids, leading to cell death (Auten and Davis, 2009

Gene regulatory mechanisms of the lncRNA Fendrr

Creator:: Koehler, Monika
Abstract:: Embryonic development, where organs and major structures begin to develop, requires precise coordination of numerous gene regulatory pathways. Fendrr is an long non-coding RNA (lncRNA) that plays a role in regulating gene expression in mesodermal tissues during early embryonic development in mouse. The lateral plate mesoderm (LPM) is an earlier...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: A triplex site is a DNA structure where three nucleic acid sequences are twisted together

Development of a diagnostic assay for Phytophthora ramorum lineage detection

Creator:: Roig-Paul, Mireia
Abstract:: Phytophthora ramorum is the causal agent of Sudden Oak Death (SOD), which is an economically and environmentally important disease causing up to 80% mortality of tanoaks in Pacific Northwest coastal forests (LeBoldus et al., 2022). There are currently four clonal lineages in the United States and Europe, named North America...
Resource Type:: Undergraduate Thesis
Full Text:: -dependent amplification of nucleic acids. Current Protocols in Molecular Biology, 104, 15.11.1-15.11.12

Studies on a transgenic approach to decrease gliadin content in wheat

Creator:: Bell, Shannon M.
Abstract:: Celiac disease, an autoimmune response triggered by the consumption of seed storage proteins of cereals, affects an estimated 1% of the human population. In the case of wheat (Triticum aestivum L.), one of the world’s most consumed cereals, alcohol-soluble proteins, the gliadins, have been identified as the allergy-eliciting agents. Previous...
Resource Type:: Undergraduate Thesis
Full Text:: like to thank Drs. Lol Cooper and Isabel Vales for helping me to get started in cereal molecular

ScholarsArchive@OSU

Phytochemical characterization of Fagonia indica and its effects on MCF-7 breast cancer cell line

Characterizing the symbiotic interactions between Rhodococcus and plants

Impacts of Tertiary Ligands in Catalysis in Thermostable Human Carbonic Anhydrase II by Site-directed Mutagenesis and Genetic Code Expansion

Computational study of the electrostatic interaction between kinesin-5/BimC and the microtubule

Identifying microRNAs by automated phylogenetic and structural analysis

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Toxicity Screening of Polycyclic Aromatic Hydrocarbons (PAHs) in Primary Human Bronchial Epithelial Cells

Gene regulatory mechanisms of the lncRNA Fendrr

Development of a diagnostic assay for Phytophthora ramorum lineage detection

Studies on a transgenic approach to decrease gliadin content in wheat

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