Index Catalog // ScholarsArchive@OSU

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Creator:: Wang, Yeong
Abstract:: Bacteriophage T4 gene 42 encodes dCMP hydroxymethylase, an enzyme unique to the deoxyribonucleotide metabolism of T-even bacteriophages. To study biochemical and biophysical properties of the enzyme, as well as the interaction of dCMP hydroxymethylase with other DNA precursor biosynthetic enzymes in vitro, availability of large amounts of the enzyme is...
Resource Type:: Dissertation
Full Text:: Organization of T4 bacteriophage genes and gene products

Deoxyribonucleotides as determinants of DNA replication fidelity in bacteriophage T4

Creator:: Sargent, Roy Geoffrey
Abstract:: Imbalanced deoxyribonucleoside triphosphate (dNTP) pools are mutagenic for DNA synthesis in both intact cells and cell-free replication systems. Almost certainly, such mutagenesis involves competition between correctly and incorrectly base-paired precursors at replication sites. However, there are certain differences between the intact cell and cell-free systems that do not always allow...
Resource Type:: Dissertation
Full Text:: fidelity in bacteriophage T4 AN ABSTRACT OF THE THESIS OF Roy Geoffrey Sargent for the degree of Doctor

Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

Creator:: Ji, Jiuping
Abstract:: A crucial factor in determining the accuracy of DNA replication is maintenance of a balanced supply of deoxyribonucleoside triphosphates (dNTPs) at replication forks. Perturbation of dNTP biosynthesis can induce dNTP pool imbalance with deleterious genetic consequences, including increased mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system,...
Resource Type:: Dissertation
Full Text:: mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system, I

Host kinases involved in DNA precursor biosynthesis during bacteriophage T4 infection

Creator:: Bernard, Mark Aguirre
Abstract:: Although the Escherichia coli host has almost all of the enzymes necessary to synthesize nucleotides needed for bacteriophage T4 DNA replication, phage genes expressed early in infection encode enzymes for de novo DNA precursor biosynthesis and salvage from degraded host DNA. Eight early enzymes and two host enzymes comprise the...
Resource Type:: Dissertation
Full Text:: : Host Kinases Involved in DNA Precursor Biosynthesis during Bacteriophage T4 Infection. Abstract

Kinetic modeling of the adsorption of structural stability mutants of bacteriophage T4 lysozyme at solid-water interfaces

Creator:: Lee, Woo-Kul
Resource Type:: Dissertation
Full Text:: Modeling of the Adsorption of Structural Stability Mutants of Bacteriophage T4 Lysozyme at Solid-Water

Enzyme associations in deoxyribonucleotide biosynthesis : anti-idiotypic antibodies as probes for direct protein-protein interactions

Creator:: Young, James Patrick
Abstract:: The ability to faithfully replicate DNA is dependent upon the maintenance and regulation of its precursors, the deoxyribonucleoside triphosphates. Enzymes encoded by the bacteriophage T4 have been widely used as models of biochemical processes. A body of evidence supports the concept that the bacteriophage T4 enzymes involved in deoxyribonucleotide biosynthesis...
Resource Type:: Dissertation
Full Text:: regulation of its precursors, the deoxyribonucleoside triphosphates. Enzymes encoded by the bacteriophage T4

Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

Creator:: Ray, Nancy Bisset
Resource Type:: Dissertation
Full Text:: Interactions with Bacteriophage T4 proteins of DNA synthesis AN ABSTRACT OF THE THESIS OF Nancy Bisset Ray

Bacteriophage T4 ribonucleotide reductase : genes and proteins

Creator:: Hanson, Eric Scott
Resource Type:: Dissertation
Full Text:: deoxyribonudeoside diphosphates. The bacteriophage T4 virus encodes nearly all the enzymes required to produce the

Protein-protein interactions in the bacteriophage T4 dNTP synthetase complex

Creator:: Shen, Rongkun
Abstract:: The enzymes of dNTP synthesis in T4 infection associate to form a multienzyme complex, the T4 dNTP synthetase complex, facilitating the flow of metabolites en route to dNTPs, and their subsequent flow into DNA. Study of protein-protein interactions helps one to understand how the enzymes in the complex are organized...
Resource Type:: Dissertation
Full Text:: presented on September 8, 2006. Title: Protein-Protein Interactions in the Bacteriophage T4 dNTP

Organization of the T4 dNTP synthetase complex at DNA replication sites

Creator:: Kim, JuHyun
Abstract:: With respect to a multienzyme complex of deoxyribonucleoside triphosphate (dNTP) synthesis somehow juxtaposed with DNA replication sites, our laboratory has demonstrated the existence of a multienzyme complex in T4-infected E. coli, named the T4 dNTP synthetase complex, but the idea of direct linkage of dNTP synthesis to DNA replication and...
Resource Type:: Dissertation
Full Text:: of Bacteriophage T4 in E. coli ...................................17 2.2 Physical linkage among

ScholarsArchive@OSU

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Deoxyribonucleotides as determinants of DNA replication fidelity in bacteriophage T4

Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

Host kinases involved in DNA precursor biosynthesis during bacteriophage T4 infection

Kinetic modeling of the adsorption of structural stability mutants of bacteriophage T4 lysozyme at solid-water interfaces

Enzyme associations in deoxyribonucleotide biosynthesis : anti-idiotypic antibodies as probes for direct protein-protein interactions

Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

Bacteriophage T4 ribonucleotide reductase : genes and proteins

Protein-protein interactions in the bacteriophage T4 dNTP synthetase complex

Organization of the T4 dNTP synthetase complex at DNA replication sites

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