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Filtering by: Creator Bermudez, Luiz E. Remove constraint Creator: Bermudez, Luiz E. Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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  • Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

    Creator:
    Early, Julie V.
    Abstract:
    Mycobacterium avium cause disseminated disease in immunocompromised people such as AIDS patients. Subsequent to crossing the intestinal epithelium, M. avium thrive within vacuoles in macrophages. The bacteria exhibit a different, more invasive, phenotype after being in macrophages compared to M. avium from laboratory conditions. We hypothesized that this intracellular phenotype...
    Resource Type:
    Dissertation
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    . Abstract approved: Luiz E. Bermudez Mycobacterium avium cause disseminated disease in

  • Disease models and infectious phenotypes of Mycobacterium avium subspecies paratuberculosis

    Creator:
    Everman, Jamie L.
    Abstract:
    Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic inflammatory bowel disease that affects ruminant populations worldwide. The characteristic stages of the disease make diagnosis difficult, resulting in silent transmission among animals in a herd for years before proper detection of the infection. The extensive...
    Resource Type:
    Dissertation
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    : ___________________________________________________ Luiz E. Bermudez Mycobacterium avium subspecies paratuberculosis (MAP) is the causative

  • Characterization of microaggregate formation by Mycobacterium avium subspecies hominissuis

    Creator:
    Babrak, Lmar
    Abstract:
    Mycobacterium avium subsp hominissuis (MAH) is an opportunistic environmental pathogen that causes respiratory and gastrointestinal illness in immunocompromised persons such as those with chronic respiratory diseases or AIDs, respectively. In recent years, there has been a significant increase in the incidence of nontuberculous mycobacterial (NTM) lung infections, including in cystic...
    Resource Type:
    Dissertation
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    : ______________________________________________________ Luiz E. Bermudez Mycobacterium avium subsp hominissuis (MAH) is an opportunistic

  • Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

    Creator:
    Joseph, Jayanthi J.
    Abstract:
    To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...
    Resource Type:
    Dissertation
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    : _____________________________________________________________________ Luiz E. Bermudez Mycobacterium avium subsp. hominissuis (M. avium) is a

  • Further Understanding Mycobacterial Biofilms and Their Interaction with the Host

    Creator:
    Rose, Sasha J.
    Abstract:
    Respiratory infections caused by nontuberculous mycobacteria (NTM), especially Mycobacterium avium, can lead to progressive, recurrent disease that is refractory to therapy. Bacterial biofilms are intrinsically resistant to a variety of stressors and pressures, including host killing mechanisms and antibiotic therapy. Though it is becoming increasingly evident that NTM biofilms are...
    Resource Type:
    Dissertation
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    Hyper-Stimulation and Apoptosis during Early Infection Sasha J. Rose and Luiz E. Bermudez

  • Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

    Creator:
    McNamara, Michael J.
    Abstract:
    Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
    Resource Type:
    Dissertation
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    Luiz E. Bermudez Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental

  • Mechanisms for the interaction of environmental mycobacteria with host cells

    Creator:
    Harriff, Melanie J.
    Abstract:
    Environmental mycobacteria are important opportunistic pathogens for many hosts, including humans, cattle, and fish. Two well-studied species are Mycobacterium avium subsp. avium, a significant cause of disseminated bacterial disease in patients with AIDS, and Mycobacterium avium subsp. paratuberculosis, the cause of Johne’s disease in cattle. Many other species that are...
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    Dissertation
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    Mycobacteria with Host Cells Abstract approved: Luiz E. Bermudez Michael L. Kent

  • Molecular mechanism of germination of Clostridium perfringens spores

    Creator:
    Paredes-Sabja, Daniel
    Abstract:
    Clostridium perfringens is the causative agent of a wide variety of diseases in animals and humans. C. perfringens can produce more than 15 toxins. However, individual strains produce a subset of these toxins. Although a small percentage of C. perfringens isolates (mostly belonging to type A) produce C. perfringens enterotoxin...
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    Dissertation
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    + sensitive E. coli mutants indicate that while GerO is capable of translocating K+ and Na+, GerQ is only

  • Bacterial pathogens and associated toxins involved in erythrophore cell aggregation

    Creator:
    Hutchison, Janine R.
    Abstract:
    Current detection methods for bacterial contamination rely on structure based detection of proteins and nucleic acids. While these methods are easy to use and reliable, they cannot evaluate the toxicity of a sample and the potential to cause disease. Previously, erythrophore cells derived from Betta splendens had been suggested as...
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    Dissertation
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    thank my committee members Dr. Luiz Bermudez, Dr. Mahfuz Sarker, Dr. Martin Schuster, and Dr. Phil

  • Vaccinia virus I7L core protein proteinase

    Creator:
    Byrd, Chelsea M.
    Abstract:
    Vaccinia virus (VV) is a large double-stranded DNA virus that is a prototypic member of the orthopoxvirus family. Previous works has showed that three of the major structural proteins found within the mature VV virion core 4a, 4b, and 25K are produced from higher molecular weight precursors at late times...
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    Dissertation
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    committee members, Dan Arp, Dan Rockey, Walt Ream, and Luiz Bermudez for constructive criticism, freedom