Index Catalog // ScholarsArchive@OSU

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Creator:: Ma, Lian
Abstract:: The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...
Resource Type:: Dissertation
Full Text:: : John Mark Christensen The first part of the dissertation is to evaluate the use of proposed and

Disposition of C H N O S in rats and three antiulcer agents in llamas

Creator:: Limsakun, Tharin
Resource Type:: Dissertation
Full Text:: Llamas Abstract approved: John Mark Christensen, Ph.D. The solubility and disposition of a new

Fish oral antigen delivery system development and optimization

Creator:: Zhang, Jia Ai (Allen)
Abstract:: Oral administration is the most practical way of vaccination of fish. It has advantages over intraperitoneal injection and immersion methods that include no stressful handling, no interference with routine fish husbandry and antigens can be delivered to the fish in their feed. An oral antigen delivery system was developed for...
Resource Type:: Dissertation
Full Text:: Optimization Abstract Approved: John Mark Christensen, Ph.D. Oral administration is the most practical

Pharmacokinetics of ampicillin, gentamicin, amikacin, and omeprazole in llamas

Creator:: Kasiwong, Srirat
Resource Type:: Dissertation
Full Text:: , Amikacin and Omeprazole in Llamas. Abstract approved: John Mark Christensen Ampicillin sodium and

1) Preparation of Acetaminophen Capsules Containing Beads Prepared by Hot-melt Direct Blend Coating Method 2) Pharmacokinetic Modeling and Monte Carlo Simulations in The Context of Additional Criteria for Bioequivalence Assessments 3) Pharmacokinetic Prediction of Levofloxacin Accumulation in Tissue and its Association to Tendinopathy

Creator:: Pham, Loan
Abstract:: The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the...
Resource Type:: Dissertation
Full Text:: would like to thank my advisor, Dr. John Mark Christensen, who from the initial research stage was

Formulation of an oral acetylsalicylic acid suspension and pharmacokinetics of parenteral thrombomodulin analogues

Creator:: Piepmeier, Edward H.
Abstract:: Sustained concentrations of active compound were maintained in vitro and in vivo for an oral and a parenteral dosage form respectively. The vehicle of a oral dosage form was modified and the molecular structure of a parenteral dosage form was modified. An oral dosage form was tested in vitro using...
Resource Type:: Dissertation
Full Text:: Analogues. 1"? Abstract approved: Redacted for Privacy Mark Christensen, rn. v. Sustained c

Pharmacokinetic analysis of antimicrobials in llamas with theoretical applications

Creator:: Al-Ghazawi, Mutasin
Resource Type:: Dissertation

Novel formulation : development of oral microparticulate non-viral DNA vaccine delivery system against infectious hematopoetic necrosis virus (IHNV) in Rainbow Trout, statistical design in matrix tablets formulation

Creator:: Tantituvanont, Angkana
Abstract:: This dissertation describes two different projects. The first is the development of an oral DNA vaccine delivery system for fish. A novel oral DNA vaccine delivery system was developed for Rainbow Trout by combining non-viral vectors (polycationic liposomes or polycationic polymer) to facilitate the DNA vaccine's uptake by cell membranes...
Resource Type:: Dissertation
Full Text:: OF AUTHORS Dr. J. Mark Christensen was involved in all aspects of this work. Benjamin E. Simon and

Pharmacokinetic analysis of antimicrobials and an anthelmintic agent in alpacas and llamas with theoretical applications

Creator:: Wattananat, Triporn
Abstract:: The pharmacokinetics of two antimicrobials were investigated in alpacas. Six healthy alpacas were each administered a single dose of 10 mg/kg of oxytetracycline by IV injection and IM injection. In addition, a single dose of 20 mg/kg of florfenicol by IV administration was given to alpacas in a separate study....
Resource Type:: Dissertation
Full Text:: . Abstract approved: J. Mark Christensen The pharmacokinetics of two aritimicrobials were investigated in

Pharmacokinetics of ibuprofen and phenylbutazone in elephants following oral administration of single and multiple doses

Creator:: Neelkant, Roopesh Kumar
Abstract:: The pharmacokinetics and dose proportionality of ibuprofen were examined in African and Asian elephants after single dose administration of 4, 5 and 6 mg/kg and on multiple dose administration. Each elephant received all the three doses and plasma ibuprofen concentrations were measured by HPLC. Approximate linearity of ibuprofen pharmacokinetics in...
Resource Type:: Dissertation

ScholarsArchive@OSU

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Disposition of C H N O S in rats and three antiulcer agents in llamas

Fish oral antigen delivery system development and optimization

Pharmacokinetics of ampicillin, gentamicin, amikacin, and omeprazole in llamas

Formulation of an oral acetylsalicylic acid suspension and pharmacokinetics of parenteral thrombomodulin analogues

Pharmacokinetic analysis of antimicrobials in llamas with theoretical applications

Novel formulation : development of oral microparticulate non-viral DNA vaccine delivery system against infectious hematopoetic necrosis virus (IHNV) in Rainbow Trout, statistical design in matrix tablets formulation

Pharmacokinetic analysis of antimicrobials and an anthelmintic agent in alpacas and llamas with theoretical applications

Pharmacokinetics of ibuprofen and phenylbutazone in elephants following oral administration of single and multiple doses

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