Index Catalog // ScholarsArchive@OSU

Cytoskeletal regulation in cell motility and invasion

Creator:: Jang, Hyo Sang
Abstract:: Cell motility and invasion are important for development, immunity, wound healing, and tumor cell metastasis. Cells on two dimensional substrates migrate in three steps: protrusion of the front end, translocation of the cell body, and retraction of the rear end. For cells to migrate efficiently, these steps need to be...
Resource Type:: Dissertation
Full Text:: and Invasion Abstract approved: Jeffrey A. Greenwood Cell motility and invasion are important for

Calpain 2 proteolysis regulates glioblastoma cell invasion

Creator:: Lal, Sangeet Kumar
Abstract:: Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...
Resource Type:: Dissertation
Full Text:: Glioblastoma Cell Invasion Abstract approved: Jeffrey A. Greenwood Glioblastoma

The aging endoplasmic reticulum

Creator:: Dixon, Brian M.
Abstract:: Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
Resource Type:: Dissertation
Full Text:: M. Hagen Hallmarks of aging include the accumulation of aberrant proteins and a lower

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Creator:: Serrill, Jeffrey D.
Abstract:: Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
Resource Type:: Dissertation
Full Text:: against Glioblastoma Cells by Jeffrey D. Serrill A DISSERTATION submitted to Oregon State

Determination of fluorinated alkyl substances in aqueous systems

Creator:: Schultz, Melissa M.
Abstract:: Fluorinated alkyl substances, which can be persistent, toxic, and bioaccumulative, have been quantitated in many densely populated and remote regions, including in air, surface waters, groundwater, and biota; however, little is known about their transport or behavior in the environment. Wastewater effluent is one of the principal routes for introducing...
Resource Type:: Dissertation
Full Text:: served on my academic committee: Dr. Vincent Remcho, Dr. John Westall, and Dr. Jeffrey Greenwood. Many

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Creator:: Stanley, Kerri A.
Abstract:: The atmospheric transport and deposition of semi-volatile organic compounds (SOCs), including current and historic use pesticides, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), to mountain ecosystems may result in the exposure of tadpoles to these SOCs. This exposure has been implicated in amphibian population declines in California. Tadpoles encounter...
Resource Type:: Dissertation
Full Text:: , Jeffrey Greenwood and Michael Borman, for their input and time I also thank past and present members

Development of innovative applications for passive sampling devices : monitoring bioavailability, risk from exposure and environmental mixture toxicity

Creator:: Allan, Sarah E.
Abstract:: Chemicals must be bioavailable for there to be a potential for exposure and consequent risk to human or environmental health. Passive sampling devices (PSDs) are used to quantify the time-integrated concentration of bioavailable contaminants. We demonstrate that PSDs can be paired with the zebrafish developmental toxicity bioassay to produce site-specific,...
Resource Type:: Dissertation
Full Text:: , Jeffrey Jenkins and Jeffrey Greenwood, have put into this project and advising me during my

Decay of atomic states strongly coupled by an oscillating field

Creator:: Greenwood, William Graham
Abstract:: Frequency distributions are calculated for the optical decay of two atomic states which are coupled by a strong, linear rf field. Both the rotating and the counter-rotating components of the field are maintained throughout the calculations. For strong fields many peaks are present in the frequency spectrum and are explained...
Resource Type:: Dissertation
Full Text:: Oscillating Field by William Graham Greenwood A THESIS submitted to Oregon State University in partial

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:: Shenvi, Swapna V.
Abstract:: Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
Resource Type:: Dissertation
Full Text:: like to thank my graduate committee members, Drs. William Baird, Balz Frei, Jeffrey Greenwood, and

Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

Creator:: Zhang, Yong
Abstract:: Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation assays of differentially-tagged PLC-β constructs and sizeexclusion chromatography of native PLC-β support homodimerization...
Resource Type:: Dissertation
Full Text:: manuscripts. Dr. Jeffrey A. Greenwood helped with the FRET experiments (chapter 2). Dr. Walter K. Vogel did

ScholarsArchive@OSU

Cytoskeletal regulation in cell motility and invasion

Calpain 2 proteolysis regulates glioblastoma cell invasion

The aging endoplasmic reticulum

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Determination of fluorinated alkyl substances in aqueous systems

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Development of innovative applications for passive sampling devices : monitoring bioavailability, risk from exposure and environmental mixture toxicity

Decay of atomic states strongly coupled by an oscillating field

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

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