Index Catalog // ScholarsArchive@OSU

Addressing ALS: Corroborating the Methodology of Studying the P2X7R Complex

Creator:: Veytsman, Edward Y.
Abstract:: Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons in the motor cortex and spinal cord. Recent evidence suggests that the purine receptor P2X7 (P2X7R) plays a central role in the pathology of ALS. Previous research indicates that P2X7R activation by oxidatively modified heat shock protein 90...
Resource Type:: Honors College Thesis
Full Text:: was used to make a DMEM mixture with 10 μg/mL polybrene. The frozen virus was thawed at 37oC

The Effect of Riluzole on P2X7 and EAAT2 Expression by Inducible Neural Progenitor Cell (iNPC)-derived Astrocytes

Creator:: Sy, Kevin
Abstract:: Although it is the first drug approved for usage to treat amyotrophic lateral sclerosis (ALS), riluzole’s mechanism of action is unknown and its therapeutic quality is hampered by its relatively short window of effectiveness. P2X7 is a purine receptor found in astrocytes and other cells, which increases calcium concentrations within...
Resource Type:: Honors College Thesis
Full Text:: c-Myc-hEAAT2, EAAT2 levels rose slightly over the course of the disease, rather than decreasing

Stand Structure of Old Growth Dry Mixed Conifer Forests in the Deschutes and Ochoco National Forests

Creator:: Merschel, Andrew G.
Abstract:: Old-growth dry-mixed conifer forests are valued as habitats for late seral forest species, for the ecosystem services and landscape diversity they provide, and for their aesthetic appeal. The structure of these forests has been heavily altered by historic logging of overstory ponderosa pine and Douglas-fir. Additionally, changes in fire regime...
Resource Type:: Honors College Thesis
Full Text:: THE THESIS OF Andrew G. Merschel for the degree of Honors Baccalaureate of Science in Natural

Understanding polycyclic aromatic hydrocarbon (PAH) toxicity and inflammation in human bronchial epithelial cells

Creator:: Valdez, Teresa
Abstract:: There is increased emphasis on understanding cumulative risk from the combined effects of chemical and non-chemical stressors as it relates to public health. Recent animal studies have identified pulmonary inflammation as a possible modifier and risk factor for chemical toxicity in the lung after exposure to inhaled pollutants; however, little...
Resource Type:: Honors College Thesis
Full Text:: Susan C. Tilton There is increased emphasis on understanding cumulative risk from the combined

Impact of Vitamin E Deficiency on Hepatic Gene Expression of CRAL_TRIO Family Proteins in a Premier Vertebrate Animal Model

Creator:: Watt, Alexander T.
Abstract:: Vitamin E (vitE) is a group of lipid-soluble antioxidants- of which alpha-tocopherol is the most biologically active and only form considered to be an essential nutrient. Through preferential binding and trafficking, the alpha-tocopherol transfer protein (α-TTP) regulates the concentration of vitE in the body. The impact of vitE deficiency on...
Resource Type:: Honors College Thesis
Full Text:: 1 2 3 4 CRAL-TRIO Gene E - M e a n F o ld C h a n g e (2 -  c t ) * gpx4a

Role of Nitrated Hsp90 in Schwannoma Cell Survival

Creator:: Kim, Sharon R.
Abstract:: Neurofibromatosis Type 2 (NF2) is a genetic tumor disorder caused by mutations that inactivate the gene coding for the Merlin tumor suppressor. Patients with NF2 develop multiple tumors throughout the nervous system, mainly schwannomas, for which there is no cure or effective treatment. In NF2, redox signaling and oxidative stress...
Resource Type:: Honors College Thesis
Full Text:: -80 °C. A Lowry assay was performed in a 96-well microplate to quantify protein concentration. 30 μg

Hi-C genome assembly of the ectomycorrhizal fungus Rhizopogon salebrosus

Creator:: Har, Skyler
Abstract:: Rhizopogon salebrosus is an abundant ectomycorrhizal fungus common throughout Western North America that forms mutualistic partnerships with Pinus species. Studied for its systematics, use in sapling nurseries, post-fire seedling establishment, and unique evolutionary history, R. salebrosus holds many secrets within its genome. This thesis aims to characterize the mating system,...
Resource Type:: Honors College Thesis
Full Text:: -closed assembly. A C G T N GC GC_stdev 0.2559 0.2444 0.2439 0.2558 0.0022 0.4883 0.0012

Janus-Type Wicking Microfluidic Devices for Separation and Collection of Plasma from Blood

Creator:: Unitan, Linus J.
Abstract:: A simple Janus-type membrane-based wicking microfluidic device fabricated on a polycaprolactone-filled glass microfiber membrane enables separation and collection of blood plasma or serum from whole blood. This device bridges the wicking and cut-capillary-based solution transport mechanisms in a single membrane. The initial portion of the device is fabricated using selective...
Resource Type:: Honors College Thesis
Full Text:: ). (9) Bandara, G. C.; Heist, C. A.; Remcho, V. T. Patterned Polycaprolactone

Stability of Super Folder Green Fluorescent Protein Under Varying Organic Solvent and Temperature Conditions

Creator:: Ho, Lylan
Abstract:: Obtaining high-resolution structures of biological macromolecules has become one of the biggest challenges in the scientific world. Dr. Wei Kong’s lab is currently working to overcome the limitations of current structure resolution techniques, such as x-ray crystallography and nuclear magnetic resonance spectroscopy. Kong’s group hopes to develop a new protein...
Resource Type:: Honors College Thesis
Full Text:: -7_20. 11. Reid, B. G.; Flynn, G. C. Chromophore Formation in Green Fluorescent Protein

Studies Toward the Synthesis of Natural Product Scaffolds

Creator:: Lusk, Jason S.
Abstract:: Part 1: A Diels-Alder Approach to the Synthesis of Novel Analogues of the Natural Product Siamenol Due to the prevalence of biaryl motifs in natural product synthesis, the Carter research group has been exploring the utility of a Diels-Alder approach to biaryl synthesis. The Diels-Alder approach involves a [4+2] cycloaddition...
Resource Type:: Honors College Thesis
Full Text:: : To a stirred solution of 14 (1.36 g) in DMF (28 mL) at 0˚C was added NaH (280 mg, 6.80 mmol, 60% in

ScholarsArchive@OSU

Addressing ALS: Corroborating the Methodology of Studying the P2X7R Complex

The Effect of Riluzole on P2X7 and EAAT2 Expression by Inducible Neural Progenitor Cell (iNPC)-derived Astrocytes

Stand Structure of Old Growth Dry Mixed Conifer Forests in the Deschutes and Ochoco National Forests

Understanding polycyclic aromatic hydrocarbon (PAH) toxicity and inflammation in human bronchial epithelial cells

Impact of Vitamin E Deficiency on Hepatic Gene Expression of CRAL_TRIO Family Proteins in a Premier Vertebrate Animal Model

Role of Nitrated Hsp90 in Schwannoma Cell Survival

Hi-C genome assembly of the ectomycorrhizal fungus Rhizopogon salebrosus

Janus-Type Wicking Microfluidic Devices for Separation and Collection of Plasma from Blood

Stability of Super Folder Green Fluorescent Protein Under Varying Organic Solvent and Temperature Conditions

Studies Toward the Synthesis of Natural Product Scaffolds

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Conference Name

Conference Section/Track

Creator

Contributor

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search