Index Catalog // ScholarsArchive@OSU

Investigation of NAE inhibitor MLN4924 against KHV replication in vitro

Creator:: Jensen, Sam I.
Abstract:: Koi herpesvirus (KHV) is a pathogen affecting common carp and ornamental koi with high morbidity and mortality. Currently, no effective treatment or vaccine is available against this virus. Cullin RING ubiquitin ligases (CRLs) are a class of host proteins that facilitate infection of DNA viruses, such as herpesviruses. Inhibitors of...
Resource Type:: Honors College Thesis
Full Text:: Ling Jin Koi herpesvirus (KHV) is a pathogen affecting common carp and ornamental koi with high

The Effect of Dissolved O₂ Level on KHV Reactivation from Latency and Pathologic analysis during KHV Reactivation

Creator:: Chen, Sammi
Abstract:: Koi herpesvirus (KHV) is a new emerging viral pathogen of koi and common carps. It has been demonstrated that KHV becomes latent in the white blood cells in the recovered koi. The latent KHV can be reactivated under stressful conditions, such as heat and injury, and the reactivated viruses can...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Ling Jin Koi herpesvirus (KHV) is a new emerging viral pathogen of koi and common

Investigation of KHV DNA Methylation during Productive and Latent Infection

Creator:: Lin, Lisa
Abstract:: Koi herpesvirus (KHV), is a highly pathogenic virus causing high mortality in common carp and koi, especially in fry. One of the unique features of herpesvirus infections is their ability to become latent following initial infection. During latent infection, only viral genome persists in the host and remains dormant in...
Resource Type:: Honors College Thesis
Full Text:: Latent Infection. Abstract approved:_____________________________________________________ Ling Jin

Interaction of the Respiratory Syncytial Virus Matrix Protein and the Cellular Adaptor Protein Complex 3µ Subunit

Creator:: Ward, Casey J.
Abstract:: Respiratory Syncytial Virus (RSV) is a leading cause of bronchopneumonia in infants and elderly. Knowledge of viral and host protein interactions is important for better understanding of the viral pathogenesis and may lead to development of novel therapeutic drugs. Here, we show that RSV Matrix (M) protein interacts with cellular...
Resource Type:: Honors College Thesis
Full Text:: Anne-Marie Girgard. I would also like to thank my committee, Dr. Manoj Pastey, Dr. Ling Jin, and

Impact of Unfolded Protein Response, USP14, and NEDD8 Inhibitors Upon Antigen Presentation in SaI/Ak and 4T1 Tumor Cell Lines

Creator:: Godil, Jamila A.
Abstract:: Antigen presentation is a mechanism used by cells to present peptides on the cell surface. Peptides, derived from both viral or self-proteins are presented on the cell surface by MHC Class I molecules to be recognized and detected by cytotoxic T cells. T cells comprise the defense system to protect...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Ling Jin, Committee Member, representing Biomedical Sciences

Oxidation Energies of Chromium and Tungsten Substituted Ni (111) Surfaces

Creator:: Roth, Anika
Abstract:: The corrosion and heat resistance properties of nickel alloys are hallmarks of their importance in infrastructure and industrial catalysis processes, but these properties are highly dependent on the chemical composition of the alloy surface. Density functional theory was used for analysis of surface oxidation of four combinations of chromium and...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Qiu Jin, Committee Member, representing CBEE

Effects of selenium supplementation during different trimesters of pregnancy on non-specific humoral immunity of pregnant beef cows and persistence of antibodies in their newborn calves

Creator:: Thompson-Hernandez, Ian
Abstract:: Immunosuppression during the periparturient period leads to increased susceptibility to infectious diseases in beef cows. Newborn calves rely on passive transfer of antibodies from their mothers at birth for protection against diseases in the first two months of age. It is unknown if supranutritional Se supplementation of cows during pregnancy...
Resource Type:: Honors College Thesis
Full Text:: ). Plates were incubated for 1 h at room temperature. After incubation, plates were washed 3 times in

Restoring and Updating the Micralyne μTK

Creator:: Wong, Derek H.
Abstract:: The Micralyne microfluidic toolkit (μTK) was an instrument built by Micralyne in the early 2000’s. It was built for electrophoresis and has a sensitive laser-induced fluorescence detection system. The updates to the system were upgrading the control GUI from running in LabVIEW 5 (Windows XP, 2000) to LabVIEW 2012 (Windows...
Resource Type:: Honors College Thesis
Full Text:: literature was done which lead to a paper by Jin and Luo where their voltage choices were analyzed. They

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: tr ol W at er c on tr ol H- 1- M 1 H- 1- M 2 H- 1- M 3 H- 2- M 1 H- 2- M 2 H

Circadian Dysregulation is Associated with Alterations in Tumor Suppressor Activity in Murine Mammary Tissue

Creator:: Aponso, Hiruni M.
Abstract:: Breast cancer is the second most common cancer among women in the US, however, only a small fraction of cases are attributable to heritable genetic mutations; the bulk arises from various behavioral and environmental factors. Loss of functional p53 is observed in over 50% of cases, and its activity relies...
Resource Type:: Honors College Thesis
Full Text:: nucleus (SCN) of the anterior hypothalamus.7,9 The clock oscillates with a 24 h periodicity which can be

ScholarsArchive@OSU

Investigation of NAE inhibitor MLN4924 against KHV replication in vitro

The Effect of Dissolved O₂ Level on KHV Reactivation from Latency and Pathologic analysis during KHV Reactivation

Investigation of KHV DNA Methylation during Productive and Latent Infection

Interaction of the Respiratory Syncytial Virus Matrix Protein and the Cellular Adaptor Protein Complex 3µ Subunit

Impact of Unfolded Protein Response, USP14, and NEDD8 Inhibitors Upon Antigen Presentation in SaI/Ak and 4T1 Tumor Cell Lines

Oxidation Energies of Chromium and Tungsten Substituted Ni (111) Surfaces

Effects of selenium supplementation during different trimesters of pregnancy on non-specific humoral immunity of pregnant beef cows and persistence of antibodies in their newborn calves

Restoring and Updating the Micralyne μTK

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Circadian Dysregulation is Associated with Alterations in Tumor Suppressor Activity in Murine Mammary Tissue

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