It is commonly accepted that for the analysis of wood beams, the neutral axis coincides with the centroid of the beam. Although this assumption is used in analysis, wood is not an isotropic material, as it has different elastic properties in the tangential, radial and longitudinal directions, nor is it...
Twenty seven modern (top 1-2cm) sediment samples from multicores retrieved from throughout coastal SE Alaska were analyzed for their organic matter content and the source composition. Total organic carbon (TOC) as well as biogenic silica (bioSi), and calcium carbonate (CaCO3) content were analyzed to evaluate the organic matter content and...
Mammary tumors are the third most common tumor in cats after cutaneous neoplasia and lymphosarcoma. More than 80% of feline mammary tumors are adenocarcinomas, which are similar to human mammary adenocarcinomas in their biologic behavior and histologic characteristics. Despite treatment with radical mastectomy, feline mammary adenocarcinoma is associated with a...
Expectations for technology proficiency in counseling and counselor education have increased; nevertheless, very little information is available in the counseling literature which describes how to effectively evaluate online resources from a design and utility standpoint. This study provides a model for such assessments, employing an affordable small scale usability study...
Mitochondria provide energy for biological cells to function, but this process is also a source of oxygen radicals that are capable of damaging nearby proteins. Mitochondrial protein damage can eventually lead to cell death, especially in the case of heart cells, where mitochondria are present in the highest concentrations. As...
Dental disease is a very prevalent and costly disease in which the symptoms, not the disease, are currently being treated. The disease is caused by pathogenic oral bacteria, many of which are a part of the Mutans Streptococci. The objective of this thesis was to find a natural substance that...
The endoplasmic reticulum (ER) is a crucial organelle in the cell where protein folding and processing occurs, and conditions that negatively affect ER functions are highly detrimental to the cell. The accumulation of unfolded/misfolded proteins in the ER leads to a condition known as ER Stress. The ER has developed...
The Elliptic Curve Digital Signature Algorithm (ECDSA) is a public key cryptosystem used for creation and verification of digital signatures in electronic documents. In this thesis, we created a Java applet that provides the functionality of the ECDSA using all of the NIST elliptic curves over GF(p). This applet was...
Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...